The prize recognizes foundational discoveries about regulatory T cells and the FOXP3 gene that redefined immune tolerance and opened avenues to treat autoimmune disease, enable transplantation, and advance immuno-oncology. ISB celebrates Dr. Brunkow’s leadership and collaborative science.
The pioneering work of Mary Brunkow and Fred Ramsdell began with a mysterious mutant mouse known as “scurfy,” leading them to identify the FOXP3 gene and unlock how regulatory T cells prevent autoimmune disease — discoveries that now point to new treatments in cancer and autoimmunity.
In a Research Roundtable presentation and Q&A, ISB President Dr. Jim Heath shared how his team is using generative AI to unlock new understanding of human immunity, and how these discoveries could help predict disease severity, improve cancer therapies, and more.
Just-published research out of ISB shows the microbial teamwork behind denitrification can collapse in polluted environments, threatening ecosystem balance and resilience.
ISB Professor Sui Huang challenges the long-held belief that genetic mutations primarily drive cancer, offering a fresh perspective that could revolutionize how we think about and treat this complex disease.
Co-Author Craig Mundie and ISB’s Dr. Jim Heath discuss AI’s rapid evolution, ethical considerations, and potential to revolutionize science and society in a compelling Town Hall event.
A team of researchers has developed a powerful new tool that could transform how doctors treat multiple myeloma, a complex and often unpredictable blood cancer.