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By integrating single-cell, proteomic, genetic, clinical, and laboratory data, the team found that these cells adopt molecular features also seen in established autoimmune diseases. The findings help explain how viral infections can disrupt immune regulation and may provide a framework for understanding and eventually preventing autoimmune complications following infection.
ISB researchers help reveal a previously hidden layer of the human proteome, identifying a new class of protein-like molecules known as “peptideins” with potential implications for cancer, immunotherapy, and human disease.
Researchers at the Institute for Systems Biology argue that combining systems biology, longitudinal multiomics data, and artificial intelligence could transform healthcare from reactive treatment to proactive prevention, enabling scientists and clinicians to detect early molecular signs of disease and intervene before symptoms appear.
From Nobel recognition and scientific firsts to transformative collaborations and community impact, 2025 marked one of the most significant years in ISB’s 25-year history.
Discussing Super Agers, Drs. Eric Topol and Lee Hood connected breakthroughs in genomics, AI, and lifestyle science to the pursuit of longer, healthier lives.
The pioneering work of Mary Brunkow and Fred Ramsdell began with a mysterious mutant mouse known as “scurfy,” leading them to identify the FOXP3 gene and unlock how regulatory T cells prevent autoimmune disease — discoveries that now point to new treatments in cancer and autoimmunity.