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Sui Huang's illustration of cancer attractors on the epigenetic landscape

ISB’s Sui Huang Challenges the Genetic Paradigm of Cancer in New Essay

ISB Professor Sui Huang challenges the prevailing view of cancer as purely genetic in a new essay published in PLOS Biology. Huang and colleagues argue that many cancers lack identifiable driver mutations, suggesting non-genetic factors and disrupted gene regulatory networks may play crucial roles in cancer development.

ISB’s Sui Huang Challenges the Genetic Paradigm of Cancer in New Essay
ISB’s Sui Huang Challenges the Genetic Paradigm of Cancer in New Essay
Drs. Wei Wei and Jim Heath

Melanoma Starts Evading Treatment Within Hours – Here’s How to Stop It

ISB researchers have uncovered a stealth survival strategy that melanoma cells use to evade targeted therapy, offering a promising new approach to improving treatment outcomes.

Melanoma Starts Evading Treatment Within Hours – Here’s How to Stop It
Melanoma Starts Evading Treatment Within Hours – Here’s How to Stop It
Innovation District Building
For the Media

About ISB

Institute for Systems Biology (ISB) is a collaborative and cross-disciplinary non-profit biomedical research organization based in Seattle. We focus on some of the most pressing issues in human health, including aging, brain health, cancer, COVID-19, as well as many infectious diseases. Our science is translational, and we champion sound scientific research that results in real-world clinical impacts. ISB is an affiliate of Providence, one of the largest not-for-profit health care systems in the United States.