The prize recognizes foundational discoveries about regulatory T cells and the FOXP3 gene that redefined immune tolerance and opened avenues to treat autoimmune disease, enable transplantation, and advance immuno-oncology. ISB celebrates Dr. Brunkow’s leadership and collaborative science.
The pioneering work of Mary Brunkow and Fred Ramsdell began with a mysterious mutant mouse known as “scurfy,” leading them to identify the FOXP3 gene and unlock how regulatory T cells prevent autoimmune disease — discoveries that now point to new treatments in cancer and autoimmunity.
ISB researchers reveal a darker side of targeted therapy: the same oncogene inhibition that shuts down cancer growth program can also ignite a stress-driven identity switch — revealing an early escape route that may shape the future of cancer treatment
A new study co-led by ISB and published in the journal Cell Reports Medicine reveals how a rare lung cancer can shift between cell types, pass through hybrid states, and build distinct tumor “neighborhoods” that may help it evade detection and resist treatment.
This winter, ISB Education engaged thousands of learners through community events, student field trips, and STEM programs — from hands-on activities at the Pacific Science Center to summer research opportunities and classroom partnerships that help students explore science and envision future careers.
Whitney Gibb used to move through life at full speed. After COVID, brain fog, fatigue, and memory loss reshaped her daily life — offering a powerful window into the realities of Long COVID and the research now working to understand it.
ISB researchers use single-cell sequencing to reveal hidden defenses against bacteriophages — and introduce a powerful new way to study phage-microbe interactions.
New research from ISB’s Gibbons Lab shows that computer models of gut metabolism can predict whether probiotics will successfully establish in an individual’s microbiome and how dietary prebiotics shape health-related molecules in the gut. The findings point toward a future of more personalized, predictable microbiome-based interventions.