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ISB Researchers Seek a Better Way to Identify Chronic Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) has been a frequent injury among U.S. combatants, and blast-related mTBI has been called the “signature injury” from nearly two decades of military conflicts in Iraq and Afghanistan. ISB researchers are working to develop new methods to identify molecular changes in the blood of war veterans diagnosed with chronic mTBI.
New Modeling Tool Allows Microbiome Researchers to Map Community Ecology to Ecosystem Function
A promising new open-source metabolic modeling tool provides microbiome researchers a path forward in predicting ecosystem function from community structure. News of the software package, called MICOM, was developed in part by researchers in ISB’s Gibbons Lab, and its uses were published in the journal mSystems.
ISB Marking 20th Anniversary with Year-Long Celebration
Letter from the president: Dr. Jim Heath announces the kickoff of a 2020 celebration marking ISB’s 20th anniversary. The year-long celebration will include an ISB-Town Hall Seattle speaker series focusing on some of the most important topics in science and health care.
A Scientist-Approved Science-Themed Holiday Gift Guide
When putting together a science-themed gift guide, you have to go to the source. So we asked ISB’s researchers for their ideas and to share what’s on their lists. Whether you’re buying for a scientist or wanting to give the gift of science, this gift guide is for you.
How Old Are You? Your Body Might Disagree With That Answer
Researchers at ISB harnessed deep molecular and physiological information to determine an individual’s biological age, which they found was reflective of overall health compared to chronological age. The findings were published in the Journals of Gerontology: Series A.
‘Innovation to Impact:’ 8th Annual Valerie Logan Luncheon Shines Light on ISB Education
The 8th Annual Valerie Logan Luncheon celebrated ISB Education’s mission of engaging entire school systems — from principals and administrators to teachers and students — to ensure all students are STEM literate. Nearly 100 people attended the event at ISB, and generously gave more than $100,000 for ISB Education.
Malaria Researchers’ Findings May Have Implications for Preventing Spread of Deadly Disease
ISB researchers and their collaborators are using systems biology approaches to learn how the malaria parasite is able to transfer to humans via the bite of an infected mosquito. The information they have uncovered may help identify new ways to prevent people from contracting the deadly disease.
ISB Unveils New Brand Ahead of 20th Anniversary
We created a new brand identity — including logo and tag line — to reflect ISB’s evolution since our inception in 2000, and ahead of our 20th anniversary. ISB is proud to be a part of the vibrant research community in Seattle, and is committed to translational and collaborative science.
New Method to Detect, Analyze Rare T Cells Another Step Toward Personalized Cancer Vaccines
Members of ISB’s Heath Lab and their collaborators have developed a way to sensitively detect and analyze neoantigen-specific T-cell populations from tumors and blood. This promising development may have implications for creating targeted, individual-specific cancer vaccines.
Using Blood to Predict Gut Microbiome Diversity
Predicting the alpha diversity of an individual’s gut microbiome is possible by examining metabolites in the blood. The robust relationship between host metabolome and gut microbiome diversity opens the door for a fast, cheap and reliable blood test to identify individuals with low gut diversity.
New Diagnostic Method Predicts Therapy Response in Lung Cancer Patients
By using single-cell analysis to measure metabolic activities in rare disseminated tumor cells taken from non-small cell lung cancer (NSCLC) patients, ISB researchers and their collaborators can accurately predict how patients will respond to various cancer therapies, and how treatments will impact a patient’s physiological performance and survival.
ISB, BHRI Collaborate to Better Understand Significant Brain Impairment
ISB has entered into a scientific partnership with the Brain Health & Research Institute (BHRI), which opens its doors on September 3 in Seattle. BHRI was created by brain health expert Dr. Mary Kay Ross, and is dedicated to the evaluation, prevention, and treatment of neurodegenerative diseases, including Alzheimer’s Disease and dementia.
The Cancer Paradox
ISB’s Dr. Sui Huang uses the theory of complex systems and applies it to cancer research. In this video Q&A, he discusses the cancer paradox and highlights the importance of understanding the mechanism of what cancer treatments can backfire in order to open a new avenue for therapy and treatments.
The Science of Pregnancy
Pregnancy is a biological necessity for survival. Traditionally, however, our knowledge about pregnancy and pregnant women have lagged. Dr. Alison Paquette, a research scientist in ISB’s Hood-Price Lab, hosted a video question-and-answer session where she discussed pregnancy, the placenta, preterm birth, and much more.
Spotlight on Caroline Cannistra, ISB Systems Research Scholar
Caroline Cannistra joined ISB in 2018 as a Systems Research Scholar. The Systems Research Scholars Program provides recent college undergraduates a springboard to become the next generation’s pioneers of interdisciplinary scientific research.
‘ENDING LYME:’ JUST-RELEASED VIDEO HIGHLIGHTS ISB’S NOVEL LYME DISEASE RESEARCH
Since national surveillance of Lyme Disease started in 1982, the number of cases reported annually has increased nearly 25-fold. Lyme Disease specialist Dr. Susan Marra recently produced a video, “Ending Lyme,” about the latest in Lyme research that features ISB Drs. Jim Heath, Lee Hood, Rob Moritz, Naeha Subramanian and Nathan Price.
Systems Medicine: Integration of Biology, Computation and Technology
ISB Co-founder Dr. Lee Hood spoke with ideaXme’s Ira Pastor about his background; biochemistry, medicine, and his pathway to founding ISB; the model of P4 medicine; the importance of technology transfer and biotech company spinoffs; his views on aging and longevity biotechnology; and much more.
‘Reimagine,’ ISB’s annual fundraiser, raises nearly $35,000 for groundbreaking science
About 75 people attended “Reimagine,” ISB’s annual fundraiser, and contributed nearly $35,000 to accelerate groundbreaking research. The event was held at The Ruins, and featured presentations by legendary biologist and ISB Co-founder Dr. Lee Hood and renowned scientist and ISB President Dr. Jim Heath.