ISB News

In First-of-Its-Kind Trial, Scientists Use CRISPR to Treat Cancer

Scientists for the first time have used CRISPR to substitute a gene to treat patients with cancer. The remarkable findings were published in the journal Nature and presented at the Society for Immunotherapy of Cancer (SITC) 2022.

The Gut Microbiome’s Supersized Role In Shaping Our Metabolome

ISB researchers have shown which blood metabolites are associated with the gut microbiome, genetics, or the interplay between both. Their findings, published in the journal Nature Metabolism, have promising implications for guiding targeted therapies designed to alter the composition of the blood metabolome to improve human health.

Spotlight on ISB Education graphic

2022-23 School Year ISB Education Highlights

From planning, creating and executing workshops for educators to forging new relationships to elevate students, the ISB Education team has been in high gear. Each month throughout the 2022-2023 academic year, we will highlight some of the top projects the team is working on.

COCOA Trial Results Show Diet, Exercise Help Some with Dementia

The recently completed, ISB-led Coaching for Cognition in Alzheimer’s (COCOA) trial shows that diet and exercise can help people suffering from dementia. Senior Research Scientist Dr. Jared Roach discussed the findings in a Research Roundtable presentation.

Alice Kane, PhD

Dr. Alice Kane Joins ISB as Ling/Obrzut Assistant Professor

ISB is excited to announce the arrival of our newest faculty member, Ling/Obrzut Assistant Professor Dr. Alice Kane. The Kane Lab will investigate the biological determinants of frailty in both males and females. In this Q&A, she discusses her research to date, her areas of interest, and much more.

Seattle Science Foundation and ISB

ISB and Seattle Science Foundation Partner to Create Video Series

What are multi-omics? Why does our microbiome matter? What’s the difference between genetics and genomics? What is a digital twin? ISB and Seattle Science Foundation have partnered to create videos answering questions like these and more, showcasing ISB scientists and their work.

Reimagining Chronic Illness: A Conversation With Meghan O’Rourke

Author Meghan O’Rourke recently joined ISB President Dr. Jim Heath for a virtual fireside chat focused on reimagining chronic illness – also the topic of O’Rourke’s New York Times bestselling book. This event was the latest in the ISB-Town Hall Seattle Science Series.

ISB President Dr. Jim Heath

ISB Leading NCI Comprehensive Cancer Center to Study Sequential Targeted Inhibitors and Immunotherapies

The NCI awarded ISB a 5-year, $13 million grant to lead a comprehensive cancer center and study sequential combinations of targeted inhibitors and immunotherapies. The program is designed to determine if the treatments yield greater patient benefit when administered in sequence rather than as monotherapies or as simultaneously administered combinations.

2022 ISB Virtual Microbiome Series

2022 ISB Virtual Microbiome Series Announced

Our multi-day microbiome-themed virtual course and symposium is back for the third year! ISB is hosting a two-day course on October 12 & 13, 2022, followed by a symposium on October 14, 2022 on global perspectives in microbiome research. Both events are virtual and free. The intended audience for these events are graduate students, postdocs, principal investigators, industry scientists, educators, clinicians, or any other variety of microbiome-curious people from across the globe.

Bugs vs. Drugs: How Our Microbiomes Can Explain Our Response to Statins

ISB Assistant Professor Dr. Sean Gibbons talked about the science behind statins in our most recent Research Roundtable virtual presentation. His talk was titled “Bugs vs. Drugs: How Our Unique Gut Microbiomes Shape Our Personalized Responses to Statins.”

Drs. Serdar Turkarslan and Christian Diener

ISB Honors Researchers Who Give Back to STEM Education

This year, two deserving scientists were bestowed recognition for giving back to STEM education. Dr. Serdar Turkarslan is the recipient of the JoAnn Chrisman Award for Distinguished Service to STEM Education, and Dr. Christian Diener was awarded the Dr. Christine Schaeffer Award for Exemplary Service to STEM Education. 

Innovator Award Program ROI

Six Years In, ISB’s Innovator Award Program an ‘Unqualified Success’ 

The fifth cycle of ISB’s Innovator Award Program officially wrapped up this week with the principal investigators of the 2021-22 projects delivering their final presentations. In April, three 2022-23 Innovator Award collaborative projects were announced. The Innovator Award Program was launched in 2017, and has been tremendously successful.  

Bringing DNA Sequencing to the High School Classroom

Christopher Lausted and Dr. Danielle Vermaak were featured guests of an ISB Research Roundtable presentation. The husband-and-wife team detailed the planning and rollout of a DNA sequencing curriculum project that was tested in Vermaak’s Lincoln High School science classroom in Seattle.

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Archive: 2021-22 School Year ISB Education Highlights

In this robust roundup from the 2021-22 academic year, we highlight the top projects the team worked on by month.

Gut Microbiome Composition Predictive of Patient Response to Statins

New ISB research shows that different patient responses to statins can be explained by the variation in the human microbiome. The findings were published in the journal Med, and suggest that microbiome monitoring could be used to help optimize personalized statin treatments.

Risk Factors for Severe COVID-19 in Hospitalized Adults Differ by Age

A just-published study provides new information about which hospitalized COVID-19 patients are most likely to need mechanical ventilation or to die. The ISB-led work shows that vital signs and lab results at the time of hospital admission are the most accurate predictors of disease severity, more so than comorbidities and demographics.

Dr. Sui Huang on the Science Behind Masks

On April 7, 2022, Dr. Sui Huang spoke at a Research Roundtable event on the topic of “The Science Behind Masks.” In light of the recent changes to masking mandates, Dr. Huang explained the science behind how masks work and gave the tools to make an informed decision for yourself.

Understanding, Preventing and Treating Long-Term Effects of COVID: RECOVER Study Enrolling Patients from Pacific Northwest

As part of a massive nationwide effort, ISB is leading a multi-site consortium for the NIH RECOVER (Researching COVID to Enhance Recovery) Initiative. The Pacific Northwest consortium is made up of ISB, Providence, Swedish, and University of Washington School of Medicine.