Much of ISB’s research falls into these main areas. Click on any of the categories below to see a range of publications from our lab groups.

  • Scientific Wellness

    Scientific Wellness embodies P4 medicine (predictive, preventive, personalized and participatory), and is being applied to help individuals improve their health. The platform provides new approaches for drug target discovery, and is driving profound economic, policy and social change.

  • Microbiome

    Understanding of the human microbiome has grown exponentially over the past decade. ISB researchers are unlocking the mysteries of the human microbiome and translating our scientific knowledge into therapies for a number of complex diseases.

  • Pregnancy Health

    By using a systems approach to pregnancy health, ISB is gaining a more comprehensive understanding of pathological changes that occur in pregnancy, which will identify women most at risk of developing pregnancy complications.

  • Sepsis

    Sepsis is a very real problem for our health care system. With no reliable biomarkers, with a variety of treatment protocols, and with individual patients presenting with a myriad of complicating factors, sepsis is a moving target. ISB researchers are collaborating with the Providence St. Joseph Health network, and are aggressively working to better understand the life-threatening illness.

  • t cell


    Cancer research poses many interconnected complexities related to early detection, stratification and treatment. The cross-disciplinary holistic, integrative nature of systems biology makes ISB researchers well suited to tackle the complexity of these diseases. 

  • Brain

    ISB researchers aim to thoroughly understand the causes and effects of neuropathologies at the molecular level through such disparate approaches as identifying molecular fingerprints of disease, identifying screening diagnostics, and building integrated regulatory-metabolic models for human cells.

  • Infectious Disease

    ISB’s systems approach is effective in making advances in global health research. Our lab groups participate in a range of areas related to infectious diseases, including tuberculosis, malaria, and dengue virus.

  • Research


    Proteomics is the discipline of identifying and quantifying the proteins present in an organism. At ISB, we use state-of-the-art scientific instruments and cutting edge computational techniques to detect thousands of proteins at once, giving us a systems-level view of the molecular machinery of life.

  • Environment

    Achieving environmental sustainability is one of civilization’s historic challenges. ISB uses systems science to improve the understanding of the interactions of microbes and ecosystems and create a new generation of sustainable tools and strategies that can be deployed to address this challenge.

  • Cell Dynamics

    Cell dynamics aims to understand biological complexity in the context of the modular organization of the cell. Systems biology with cell biology combine to help study the origins and dynamics of organelles to understand the networks that underlie cellular function and dysfunction.

  • PD3

    Computational Biology

    Many projects at ISB, from cancers to rare genetic diseases, entail the development of computational and mathematical approaches for modeling biological systems and analyzing large-scale measurement data sets.