Infectious Disease

ISB’s systems approach is effective in making advances in global health research. Our lab groups participate in a range of areas related to infectious diseases, including tuberculosis, malaria, and dengue virus.

Featured Projects

  • Method Developed to Profile Pathogen Gene Expression from Infected Host Cells

    The rise in multi-drug resistant and extremely drug resistant strains of Mycobacterium tuberculosis has become a major cause of global health concern for treating tuberculosis. ISB researchers developed Path-seq, a method that profiles host and pathogen gene expression and can explore the pathogen transcriptome in vivo.

  • Wilke Cohen Lyme Disease Project

    ISB researchers have put their efforts into looking at Lyme disease and the bacteria, Borrelia burgdorferi, that causes the disease, through the lens of systems biology, and utilizing approaches pioneered at ISB to gather, synthesize and interpret large and complex datasets.

  • Warhol style Plasmodium

    Identification of the proteins in Plasmodium vivax provide new targets for a malaria vaccine

    Scientists from ISB and the Center for Infectious Disease Research led an international collaboration to identify proteins in the malaria parasite Plasmodium vivax. P. vivax and P. falciparum cause the majority of malaria cases, but P. vivax is far less-studied, in part because it cannot be grown in the lab. The research aims to provide new targets for a malaria vaccine.

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