RESEARCH
Researchers across labs and disciplines at ISB, along with the global scientific community at large, are working to uncover the secrets behind COVID-19 and SARS-CoV-2, the virus that causes the disease.
RESEARCH
Research suggests that it may be possible to eliminate the correlation between age and diseases. ISB is working to leverage systems biology approaches to understand the mechanistic links among the processes that accompany and/or lead to aging.
PHILANTHROPY
We are a nonprofit research organization and the first-ever institute dedicated to systems biology. We believe in the power of science transforming health.
You are committed to a better future, ISB is here to make that a reality.
RESEARCH
ISB and our collaborative network of partners is pioneering a multimodal approach that combines personal data, lifestyle factors, cognitive training and systems medicine, and is rigorously testing these new approaches in clinical trials. This approach is critical to prevent, slow, and even reverse many neurological conditions before they become irreversible.
Each month throughout the 2023-2024 academic year, we will highlight some of the top projects the ISB Education team is working on.
ISB Associate Professor Dr. Sean Gibbons was named a Highly Cited Researcher for 2023. It is the second consecutive year Gibbons has earned the distinction. The Highly Cited Research list is generated annually by Clarivate, which says: “Of the world’s population of scientists and social scientists, Highly Cited Researchers are 1 in 1,000.”
In a breakthrough discovery that changes how we understand T cells and with implications of how we can better engineer custom immune responses to fight disease, Institute for Systems Biology researchers showed that the different disease-fighting functions of different T cells are determined by the genetically encoded T-cell receptor sequence that are unique to those cells.
By using a computer model to understand the adaptions of Mycobacterium tuberculosis (Mtb), the pathogen that causes tuberculosis, researchers at ISB have identified a network within Mtb that allows it to tolerate and resist drug therapies. This work is published in Cell Reports.
Supplementing the standard of treatment for Alzheimer’s disease patients with personalized lifestyle coaching leads to less cognitive decline compared to standard of treatment alone, according to an ISB-led two-year study. The results were published in the Journal of Alzheimer’s Disease.
Sarah Clemente recently joined ISB as a Systems Thinkers in STEM Ambassador Coordinator, and is the third AmeriCorps member to work with us. In this Q&A, Clemente shares what drew her to ISB, what she hopes to accomplish over the next year, and more.
In light of the recent FDA and CDC decision to approve two updated messenger RNA COVID-19 booster shots, it is imperative to alert the pregnant population of the importance and effectiveness of these vaccines and boosters.
ISB researchers Nitin Baliga, Serdar Turkarslan, Mario Arrieta-Ortiz and Yaqiao Li collaborated with the University of Washington to present the first glimpse of the molecular mechanisms behind the unusual lifestyle of a group of tiny microbes called Patescibacteria. The breakthrough was made possible by the discovery of a way to genetically manipulate these bacteria, an advance that has opened a world of possible new research directions.
High school students Ashwin Mukherjee and Rohan Chanani worked with ISB Research Scientist Dr. Jacob Valenzuela on a project to build a machine learning algorithm to count algal cells from microscope images taken from a cell phone. In April, the team was recognized as champions in the DOE-sponsored AlgaePrize competition.
