The Institute for Systems Biology, where science solves problems, saves lives, and benefits human life on a global scale. If that’s not beautiful, we don’t know what is.
A microbial community-scale metabolic model of an individual’s gut generated by MICOM data and the data visualization tool Gephi. Image credit: Gibbons Lab/ISB.
ISB is uncovering new solutions to the world’s most pressing health problems.
ISB Building at dusk in South Lake Union, Seattle. Photo credit: Trevor Dykstra.
ISB employs over 170 staff with expertise across a wide range of disciplines. Our teams span multiple scientific fields, with molecular biologists, geneticists, software engineers, computational biologists, and even microbial ecologists working together.
Members of the Kuchina Lab working at ISB in Seattle. Photo credit: Scott Eklund/Red Box Pictures.
The Institute for Systems Biology (ISB) is a nonprofit scientific research organization located in Seattle. We believe that science has the power to transform health. You have an opportunity to play an essential role in the future of human health. When you get involved, you enable our researchers to tackle some of the biggest challenges of our time. Together we can build a better, brighter, healthier future.
Cancer is complex and requires a sophisticated systems approach to understand and treat it. ISB researchers are pursuing several complex and cross-disciplinary means to better create more personalized therapeutics and simulate which treatments will be most effective.
Each of us has a microbiome — trillions of microorganisms that reside in and on our bodies. ISB researchers study the microbiome’s role in human health and translate this knowledge into approaches designed to promote better health for every individual.
Our infectious disease research addresses a wide range of global health initiatives. We are exploring new approaches that focus on cutting-edge treatments and preventive measures to fight infectious diseases.
Read the latest news of our transformational research, devoted scientists and educators, recent and upcoming events, and much more.
Scientists at the Institute for Systems Biology (ISB) reveal how T cells “decide” their fate in fighting infections like COVID-19, paving the way for improved treatments for infections, cancer, and autoimmune diseases.
We are deeply saddened to share the passing of renowned artist Ginny Ruffner earlier this year at 72. Ginny has long been an integral part of ISB’s community. Her vibrant artwork continues to bring life to our spaces, and her advocacy as a Foundation Board member leaves a lasting legacy.
In the January installment of the 2024-25 academic year roundup, we detail how the rush of summer intern applicants taxed our intake system, and more.
A purple ribbon, the color for gynecologic cancers, composed with diverse faces illustrated by Stacey Knipe.
The Women’s Health Consortium, led by ISB President Dr. Jim Heath, is taking a collaborative approach to engineered T cell immunotherapy to benefit women of all ethnicities with advanced HPV+ cancers. Your support will help us bring innovative therapies to patients in need.
President and Professor Jim Heath is dedicated to advancing precision medicine from benchtop to bedside, particularly in oncology. His research addresses fundamental scientific bottlenecks that can unlock solutions to broader challenges.
Professor Wei Wei’s research focuses on molecular and cellular analysis within systems biomedicine. The Wei Lab aims to tackle critical questions and foster new insights in fundamental and translational cancer research.
Assistant Professor Anna Kuchina studies bacteria at the single-cell level, using advanced technologies to understand how bacteria behave in complex settings such as biofilms living in the human body.