All News - Institute for Systems Biology (ISB)

This circular workflow illustrates how personalized medicine is applied using the mmSYGNAL model. Starting with molecular profiling of a new patient, data are mapped to the mmSYGNAL network — originally built from a large patient cohort — and integrated with our MM knowledge base to generate a patient-specific disease network map. This map supports risk prediction and therapy matching, which are synthesized by a Clinical Decision Support Service to provide actionable insights for the treating physician, enabling tailored and informed treatment decisions.

Posted: April 2, 2025

New Model Transforms Multiple Myeloma Risk Prediction

A team of researchers has developed a powerful new tool that could transform how doctors treat multiple myeloma, a complex and often unpredictable blood cancer.

Sui Huang's illustration of cancer attractors on the epigenetic landscape

Posted: March 26, 2025

ISB’s Sui Huang Challenges the Genetic Paradigm of Cancer in New Essay

ISB Professor Sui Huang challenges the prevailing view of cancer as purely genetic in a new essay published in PLOS Biology. Huang and colleagues argue that many cancers lack identifiable driver mutations, suggesting non-genetic factors and disrupted gene regulatory networks may play crucial roles in cancer development.

Posted: March 20, 2025

Melanoma Starts Evading Treatment Within Hours – Here’s How to Stop It

ISB researchers have uncovered a stealth survival strategy that melanoma cells use to evade targeted therapy, offering a promising new approach to improving treatment outcomes.

Posted: February 18, 2025

Scientists Decode Diet From Stool DNA – No Questions Asked

ISB's Gibbons Lab developed a breakthrough method that analyzes food-derived DNA in fecal metagenomes, allowing for data-driven diet tracking without the need for burdensome questionnaires.

Posted: February 8, 2025

New Research Uncovers Hidden Rules of Immune Response

Scientists at the Institute for Systems Biology (ISB) reveal how T cells "decide" their fate in fighting infections like COVID-19, paving the way for improved treatments for infections, cancer, and autoimmune diseases.

Posted: December 4, 2024

ISB Named Winner of 2024-2025 Amazon Web Services IMAGINE Grant for Nonprofits

ISB has been selected as a winner of the 2024 Amazon Web Services (AWS) IMAGINE Grant. The grant will support ISB’s continued development of My Digital Gut, an online decision-support platform that will help make microbiome-informed nutrition and healthcare personalized, predictive, and preventive.