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An international team of researchers, including scientists from the Institute for Systems Biology, has conducted one of the most comprehensive molecular studies of human diversity to date. Published in Cell, the work reveals how ethnicity and geography influence metabolism, immunity, the microbiome, and biological aging — insights that could help advance precision medicine for diverse populations.
Researchers at the Institute for Systems Biology have developed a powerful new platform that can identify and deeply profile antigen-specific CD4+ T cells at unprecedented scale and resolution. Published in Nature Communications, the work could help accelerate vaccine design, improve immune monitoring, and advance next-generation cancer immunotherapies.
ISB researchers show that oxidative stress generated by the host immune system can prime tuberculosis bacteria to rapidly evolve antibiotic resistance, revealing how resistance may begin before treatment.
ISB researchers help reveal a previously hidden layer of the human proteome, identifying a new class of protein-like molecules known as “peptideins” with potential implications for cancer, immunotherapy, and human disease.
ISB’s Dr. Alice Kane explores the biology of aging, highlighting frailty as a key measure of healthspan, new biomarkers of aging, and insights into menopause and women’s health.
ISB researchers reveal a darker side of targeted therapy: the same oncogene inhibition that shuts down cancer growth program can also ignite a stress-driven identity switch — revealing an early escape route that may shape the future of cancer treatment