ISB News

New Study Identifies Organ-Specific Biomarkers for Acute Liver Injury

ISB scientists recently published a study in the Journal of Proteome Research that presents results from a study on identifying organ-specific blood biomarkers for acute liver injury due to over-exposure to acetaminophen. From the summary: 3 Bullets: Finding organ-specific blood biomarkers for disease that are clinically useful is challenging. New study identifies organ-specific blood biomarkers for acute liver injury caused by over-exposure to acetaminophen. ISB researchers use the powerful, targeted…

Aitchison Lab Accepts ALS Ice Bucket Challenge

Jennifer Smith, senior research scientist in the John Aitchison Lab, was tagged to do the ALS Ice Bucket Challenge. And because the Aitchison group studies ALS, Jennifer’s lab mates took the challenge, too. Jennifer offered this description of the work they are doing to create a blood test for early detection of ALS: ISB is developing a multi-component blood-based assay (blood test) for early detection and disease tracking of ALS….

Cancer Detection requires a cross-disciplinary, systems biology approach.

Cancer Detection: A Systems Biology Approach

By Martin Shelton ISB Editorial Board Member With the exception of cancers of the skin, mouth, and blood, it is difficult to detect cancer by sight or with a routine health screen. The natural variety that exists at the cellular level — even within cells of the same type — challenges our ability to differentiate healthy tissue from diseased. This variety, what biologists call heterogeneity, means that equally healthy cells…

Cancer stratification: Using a systems approach to figure out cancer subtypes.

Cancer Stratification: A Systems Approach

By Theo Knijnenburg ISB Editorial Board Member When a patient receives a diagnosis of breast cancer, it’s a specific subtype of breast cancer, such as invasive ductal carcinoma. Each subtype is characterized by the shape and location of the tumor, its growth progression, prognosis and treatment. The ability to stratify, or group, cancer patients based on the specific characteristics of their cancer type, is the first step toward personalized cancer…

Results of the steady-state Markov model. The state transition and ‘self-renewal’ probabilities required to reach the steady state, shown as heat map

Cancer Treatment: A Systems Approach

By Sui Huang and Joseph Zhou, ISB Editorial Board Members Cancer cells, for decades regarded as a uniform mass of identical (“clonal”) cells, are not like the soldiers of a traditional army, trained to act and respond in unison. Cancer cells, even within a genetic clone, express enormous individuality akin to guerrilla fighters, each with unique strengths, weaknesses and distinct behaviors. Therefore, they do not respond to an attack from…

ISB, Lee Hood on Forbes.com

John Nosta, a contributor to Forbes.com, posted this piece today and included a mention of a collaboration between Indi and ISB on a diagnostic that may help identify benign lung nodules. From Diagnosis to Treatment, Has Lung Cancer Begun To Turn The Corner? This study suggests the tremendous power of using systems biology and bioinformatics to better understand health and disease,” said Lee Hood, M.D., Ph.D., co-author of the study; co-founder…