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Dr. Andrew Magis: Identifying Markers for Cancer Years Before Diagnosis
By taking detailed measurements of blood and other biological samples, ISB scientists have shown they can identify markers for cancer years before diagnosis. This was the topic of a recent Research Roundtable presentation delivered by Dr. Andrew Magis, Director of Data Science in ISB’s Health Data Science Lab.
ISB Researchers Show Genetic Risk for Disease Often Reflected in Our Blood
Diseases develop gradually over years, sometimes decades, before symptoms appear, and are due to malfunctioning physiological processes brought about by our genes and environment. In research published in the journal Proceedings of the National Academy of Sciences (PNAS), ISB researchers have shown how an individual’s genetic risk for disease is often reflected in their blood.
New Study Identifies Organ-Specific Biomarkers for Acute Liver Injury
ISB scientists recently published a study in the Journal of Proteome Research that presents results from a study on identifying organ-specific blood biomarkers for acute liver injury due to over-exposure to acetaminophen. From the summary: 3 Bullets: Finding organ-specific blood biomarkers for disease that are clinically useful is challenging. New study identifies organ-specific blood biomarkers for acute liver injury caused by over-exposure to acetaminophen. ISB researchers use the powerful, targeted…
Cancer Detection: A Systems Biology Approach
By Martin Shelton ISB Editorial Board Member With the exception of cancers of the skin, mouth, and blood, it is difficult to detect cancer by sight or with a routine health screen. The natural variety that exists at the cellular level — even within cells of the same type — challenges our ability to differentiate healthy tissue from diseased. This variety, what biologists call heterogeneity, means that equally healthy cells…
Cancer Stratification: A Systems Approach
By Theo Knijnenburg ISB Editorial Board Member When a patient receives a diagnosis of breast cancer, it’s a specific subtype of breast cancer, such as invasive ductal carcinoma. Each subtype is characterized by the shape and location of the tumor, its growth progression, prognosis and treatment. The ability to stratify, or group, cancer patients based on the specific characteristics of their cancer type, is the first step toward personalized cancer…
Cancer Treatment: A Systems Approach
By Sui Huang and Joseph Zhou, ISB Editorial Board Members Cancer cells, for decades regarded as a uniform mass of identical (“clonal”) cells, are not like the soldiers of a traditional army, trained to act and respond in unison. Cancer cells, even within a genetic clone, express enormous individuality akin to guerrilla fighters, each with unique strengths, weaknesses and distinct behaviors. Therefore, they do not respond to an attack from…
ISB, Lee Hood on Forbes.com
John Nosta, a contributor to Forbes.com, posted this piece today and included a mention of a collaboration between Indi and ISB on a diagnostic that may help identify benign lung nodules. From Diagnosis to Treatment, Has Lung Cancer Begun To Turn The Corner? This study suggests the tremendous power of using systems biology and bioinformatics to better understand health and disease,” said Lee Hood, M.D., Ph.D., co-author of the study; co-founder…