ISB News

How Bacteria Build Communities That Can Impact Your Health

Bacteria are much more than single-celled organisms swimming around. Bacteria also form communities called biofilm, and work together to maintain the microbial community. Biofilm is just one research area of ISB’s Kuchina Lab. In this Research Roundtable presentation, ISB Assistant Professor Dr. Anna Kuchina details her work studying biofilms.

Ginny Ruffner and Dr. Jim Heath Explore the Intersection of Art and Science

Renowned artist Ginny Ruffner and ISB President Dr. Jim Heath delivered a lecture at Town Hall Seattle about the intersection of art and science. They spoke about how creation stories tie scientists and artists together, and how their approaches are both similar and different from that point on.

In First-of-Its-Kind Trial, Scientists Use CRISPR to Treat Cancer

Scientists for the first time have used CRISPR to substitute a gene to treat patients with cancer. The remarkable findings were published in the journal Nature and presented at the Society for Immunotherapy of Cancer (SITC) 2022.

The Gut Microbiome’s Supersized Role In Shaping Our Metabolome

ISB researchers have shown which blood metabolites are associated with the gut microbiome, genetics, or the interplay between both. Their findings, published in the journal Nature Metabolism, have promising implications for guiding targeted therapies designed to alter the composition of the blood metabolome to improve human health.

COCOA Trial Results Show Diet, Exercise Help Some with Dementia

The recently completed, ISB-led Coaching for Cognition in Alzheimer’s (COCOA) trial shows that diet and exercise can help people suffering from dementia. Senior Research Scientist Dr. Jared Roach discussed the findings in a Research Roundtable presentation.

Seattle Science Foundation and ISB

ISB and Seattle Science Foundation Partner to Create Video Series

What are multi-omics? Why does our microbiome matter? What’s the difference between genetics and genomics? What is a digital twin? ISB and Seattle Science Foundation have partnered to create videos answering questions like these and more, showcasing ISB scientists and their work.

Reimagining Chronic Illness: A Conversation With Meghan O’Rourke

Author Meghan O’Rourke recently joined ISB President Dr. Jim Heath for a virtual fireside chat focused on reimagining chronic illness – also the topic of O’Rourke’s New York Times bestselling book. This event was the latest in the ISB-Town Hall Seattle Science Series.

Bugs vs. Drugs: How Our Microbiomes Can Explain Our Response to Statins

ISB Assistant Professor Dr. Sean Gibbons talked about the science behind statins in our most recent Research Roundtable virtual presentation. His talk was titled “Bugs vs. Drugs: How Our Unique Gut Microbiomes Shape Our Personalized Responses to Statins.”

Bringing DNA Sequencing to the High School Classroom

Christopher Lausted and Dr. Danielle Vermaak were featured guests of an ISB Research Roundtable presentation. The husband-and-wife team detailed the planning and rollout of a DNA sequencing curriculum project that was tested in Vermaak’s Lincoln High School science classroom in Seattle.

Gut Microbiome Composition Predictive of Patient Response to Statins

New ISB research shows that different patient responses to statins can be explained by the variation in the human microbiome. The findings were published in the journal Med, and suggest that microbiome monitoring could be used to help optimize personalized statin treatments.

Predicting ‘Long COVID’ At Initial Point of COVID-19 Diagnosis

Researchers have identified several factors that can be measured at the initial point of COVID-19 diagnosis that anticipate if a patient is likely to develop long COVID. They also found that mild cases of COVID-19, not just severe cases, are associated with long COVID. Their findings were published by the journal Cell.

Maternal COVID-19 Infection Increases Risks of Preterm Birth, Low Birth Weight and Stillbirth

An ISB-led study examined the electronic health records of more than 18,000 people with SARS-CoV-2 tests during pregnancy, and found that those who contracted COVID-19 while pregnant were more likely to have poor birth outcomes including preterm birth, small for gestational age, low birth weight, and stillbirth. 

Dr. Jack Gilbert on the State of the Microbiome Field

In the final ISB-Town Hall Seattle Science Series of 2021, ISB Assistant Professor Dr. Sean Gibbons sat down with UCSD Professor Dr. Jack Gilbert, and the two microbiome experts discussed past research, exciting science happening today, promising products and therapies on the horizon, and much more. 

Reimagine: Your Immune System Event Generates $60,000 to Fuel Critical ISB Research

More than 300 people registered for Reimagine: Your Immune System, ISB’s annual virtual fundraiser, for an evening that included guest appearances Nobel laureate Dr. David Baltimore, immunology expert Dr. Mark Davis, ISB President Dr. Jim Heath, and a host of ISB researchers studying the human immune system.

Nir Barzilai on Health Span, Life Span and the New Science of Longevity

Longevity and aging researcher Dr. Nir Barzilai participated in a fireside chat conversation with ISB Co-founder and Professor Dr. Lee Hood. The two renowned scientists talked about Barzilai’s study of 750 centenarians, how aging research has changed over the years, and what exciting developments are coming. 

Dr. Andrew Magis: Identifying Markers for Cancer Years Before Diagnosis

By taking detailed measurements of blood and other biological samples, ISB scientists have shown they can identify markers for cancer years before diagnosis. This was the topic of a recent Research Roundtable presentation delivered by Dr. Andrew Magis, Director of Data Science in ISB’s Health Data Science Lab.

Why ISB’s Biobank Is Second to None

ISB has developed a biobank that is second to none. In this video, Dr. Jim Heath gives a behind-the-scenes look at the process of creating a biorepository, from taking the handoff of de-identified patient samples at the clinic to storing the processed samples in a deep-freeze cryo-chamber.

How Will Healthcare and Scientific Research Be Different in a Post-Pandemic World?

Providence President and CEO Dr. Rod Hochman joined ISB President and Professor Dr. Jim Heath for an hour-long conversation hosted by ISB and Town Hall Seattle about how healthcare and science will be different in a post-pandemic world.