ISB News

Baliga Lab: New Publication in ‘Nature Microbiology’

The Baliga Lab and colleagues at Center for Infectious Disease Research published (online in advance of print) this landmark study today in the journal Nature Microbiology:

Seattle researchers created a genetic blueprint of the cunning tuberculosis bacteria, then used it to predict and rank potential drug targets

3 Bullets:

  • Researchers at the Institute for Systems Biology and Center for Infectious Disease Research have deciphered how the human pathogen Mycobacterium tuberculosis is able to tolerate the recently approved FDA drug
  • The study demonstrated that silencing certain regulatory genes in the bacteria, or pairing with a second drug pretomanid, disrupts a tolerance gene network to improve efficacy of killing by bedaquiline.
  • This systems-approach to rational drug discovery represents significant advance in the fight against tuberculosis, which affects a third of the global population, surpassing HIV/AIDS in the number of deaths worldwide.

Read the full summary

 

Recent Articles

  • Reich, Heath on Vaccines

    Dr. Jennifer Reich Talks Vaccines and COVID In ISB-Town Hall Seattle Livestream

    Sociologist Dr. Jennifer Reich, author of “Calling the Shots,” was the featured speaker of a virtual event hosted by ISB and Town Hall Seattle. She discussed the complex and increasingly political world of vaccines, how vaccines are viewed as a personal consumption product vs. a public health solution, COVID-19 vaccine development, and more.

  • Keystone Taxa Indispensable for Microbiome Recovery

    How can we harness successional ecology to quickly repair antibiotic-damaged gut microbiota? ISB Assistant Professor Dr. Sean Gibbons wrote this commentary for the journal Nature Microbiology detailing recent research that answers that question. Click the link to read the story (link will open as a new window). Illustration by Allison Kudla, PhD / ISB. 

  • Illustration depicting an individual's genetic risk for disease being "reflected."

    ISB Researchers Show Genetic Risk for Disease Often Reflected in Our Blood

    Diseases develop gradually over years, sometimes decades, before symptoms appear, and are due to malfunctioning physiological processes brought about by our genes and environment. In research published in the journal Proceedings of the National Academy of Sciences (PNAS), ISB researchers have shown how an individual’s genetic risk for disease is often reflected in their blood.