ISB News

Glioblastoma tumor slice and corresponding density map

Looking at Tumors Through a New Lens

To improve the efficacy of neoadjuvant immune checkpoint blockade against glioblastoma, researchers are looking for vulnerabilities in surgically removed tissues – a difficulty due to the vast differences within the tumor and between patients. To address this, ISB researchers and their collaborators developed a new way to study tumors.

Coaching for Cognition in Alzheimer’s (COCOA) Clinical Trial Nearly Complete

The multi-year Coaching for Cognition in Alzheimer’s (COCOA) clinical trial is nearly complete. The trial examined diet, exercise and cognitive training as possible non-pharmacological interventions to Alzheimer’s, with some trial members receiving telephonic coaching centered on stress, diet and exercise, as well as brain training focusing on brain speed and attention.

A New Approach to Alzheimer’s Disease

The impact of Alzheimer’s Disease is staggering – 6 million Americans diagnosed, a financial toll of $600 billion annually, and no effective drug treatments. ISB Co-founder Dr. Lee Hood said the traditional approach isn’t working, and we need to think about it in brand new ways.

Personalized Nutrition and Your Gut Microbiome

In ISB’s first-ever Research Roundtable event, Assistant Professor Dr. Sean Gibbons delivered a presentation titled “Gut-Check: Personalized Nutrition and Your Microbiome.” His talk covered a lot of ground, including recently published research showing how the health of our microbiomes can predict longevity, and how we can build and maintain a healthy gut microbiome.

Dr. Wei Wei and Dr. Xiaowei Yan

A Better Way to Find Circulating Tumor Cells in Non-Small Cell Lung Cancer Patients

Despite the aggressive nature of Non-Small Cell Lung Cancer (NSCLC), circulating tumor cells that lead to metastases often go undetected in the blood. ISB researchers in Dr. Wei Wei’s lab and their collaborators have developed a novel method to better detect these circulating cells.

Drs. Nitin Baliga and Serdar Turkarslan

ISB Researchers Discover How Microorganisms Evolve Cooperative Behaviors

ISB research sheds light on how interspecies interactions arise, evolve and are maintained. The results, published in The ISME Journal, provide a new window to understand the key roles of these interactions in industrial applications, and in the health and disease of humans, animals and plants.

Drs. Naeha Subramanian, Leah Rommereim Gilmore, and Ajay Suresh Akhade

Small, Persistent Increase in the Expression of NOD1 May Promote Cancer Risk

ISB researchers have found that a small, persistent increase in the expression of NOD1 could be responsible for higher cancer risks. The research team found that a slight 1.5-fold uptick in NOD1 expression can activate the protein and downstream signaling pathways in a manner similar to vast (30- to 200-fold) overexpression.

Priyanka Baloni

Bile Acids Provide More Evidence of the Gut Microbiome’s Effect on Alzheimer’s Disease

ISB researchers and their collaborators are looking beyond the one-drug, one-solution approach that has thus far failed in Alzheimer’s disease research. Instead, they are focusing on other promising research avenues, such as the possible role of the gut microbiome in dementia.

Subramanian and Akhade

How Salmonella Co-Opts the Host Immune System to Conceal Itself

While scientists have long studied bacterial infections, less attention has been paid to how the host immune response affects bacterial gene expression in the body. In a just-published paper in PNAS, ISB researchers detailed how the bacterium Salmonella conceals itself from the host immune system.

Overall composition of gut microbiome in participants

Variations in the Microbiome Associated with Health, Disease

ISB researchers examined the associations between the gut microbiomes of about 3,400 people and roughly 150 host characteristics. The team looked at diet, medication use, clinical blood markers, and other lifestyle and clinical factors, and found evidence that variations of the gut microbiome are associated with health and disease.

Malaria Researchers’ Findings May Have Implications for Preventing Spread of Deadly Disease

ISB researchers and their collaborators are using systems biology approaches to learn how the malaria parasite is able to transfer to humans via the bite of an infected mosquito. The information they have uncovered may help identify new ways to prevent people from contracting the deadly disease.

Using Blood to Predict Gut Microbiome Diversity

Predicting the alpha diversity of an individual’s gut microbiome is possible by examining metabolites in the blood. The robust relationship between host metabolome and gut microbiome diversity opens the door for a fast, cheap and reliable blood test to identify individuals with low gut diversity.

New Diagnostic Method Predicts Therapy Response in Lung Cancer Patients

By using single-cell analysis to measure metabolic activities in rare disseminated tumor cells taken from non-small cell lung cancer (NSCLC) patients, ISB researchers and their collaborators can accurately predict how patients will respond to various cancer therapies, and how treatments will impact a patient’s physiological performance and survival.

Reconstructing 'Ötzi' the Iceman’s last meal

Members of the Moritz lab, as part of an international consortium centered in Bolzano Italy, reports this week in Cell, “Current Biology”, a multi-omic approach to identify the stomach contents and microbiome of the 5300 year old Mummy, Oetzi, the Iceman from the Oetzal Alps on the Austrian/Italian border.

Adaptive Prediction of Yeast

New Study on How Microbes Learn to Predict the Future

In a study published in Genome Biology and Evolution, researchers at Institute for Systems Biology (ISB) designed an experiment to evolve novel adaptive prediction capability in yeast by repetitively exposing it to caffeine, followed by a toxin. Remarkably, the yeast cells learned the structure of this novel environmental pattern within as few as 50 generations to use caffeine as a cue for anticipating and mitigating lethal effects of the toxin.

Pioneer 100 Study

Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness

Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness. Personal, dense, dynamic data clouds enable novel insights into mechanisms of wellness and disease, new approaches to biomarker discovery, and the empowerment of individuals to enhance their own health.

New Study: Using Single-Cell Technology to Predict Cell Behavior

In a study published in PLOS BIOLOGY, researchers at Institute for Systems Biology (ISB) explain how they developed a new theory for predicting cell-fate decisions and demonstrate, for the first time, that cells indeed undergo a critical transition – or tipping point – when they commit to a particular lineage. Jan. 9, 2017 3 Bullets: ISB researchers developed a new theory that uses state-of-the-art single-cell technology to make predictions about…

New Study Identifies Organ-Specific Biomarkers for Acute Liver Injury

ISB scientists recently published a study in the Journal of Proteome Research that presents results from a study on identifying organ-specific blood biomarkers for acute liver injury due to over-exposure to acetaminophen. From the summary: 3 Bullets: Finding organ-specific blood biomarkers for disease that are clinically useful is challenging. New study identifies organ-specific blood biomarkers for acute liver injury caused by over-exposure to acetaminophen. ISB researchers use the powerful, targeted…