ISB News

New Research on IBD from ISB’s Family Genomics Group

Our Family Genomics group and collaborators analyzed the whole genome sequences of five families with high burden of inflammatory bowel disease (IBD) in order to elucidate the genomic architecture of IBD. Read about the research here…

3 Bullets:

  • In medical genetics it is an unsolved question to what degree complex diseases are influenced by rare variants with potentially large effects in relation to the many common and weak-effect variants that have been identified in genome-wide association studies (GWAS).
  • By analyzing whole-genome sequences of five families with a high burden of inflammatory bowel disease (IBD) we aimed to elucidate the genomic architecture of IBD.
  • We identified rare candidate variants and followed up one of them, a novel missense variant in TRIM11. We found evidence that the variant may foster IBD development by increasing inflammatory signaling in the gut.

Recent Articles

  • Spotlight on ISB Education graphic

    2022-23 School Year ISB Education Highlights

    From planning, creating and executing workshops for educators to forging new relationships to elevate students, the ISB Education team has been in high gear. Each month throughout the 2022-2023 academic year, we will highlight some of the top projects the team is working on.

  • How Bacteria Build Communities That Can Impact Your Health

    Bacteria are much more than single-celled organisms swimming around. Bacteria also form communities called biofilm, and work together to maintain the microbial community. Biofilm is just one research area of ISB’s Kuchina Lab. In this Research Roundtable presentation, ISB Assistant Professor Dr. Anna Kuchina details her work studying biofilms.

  • Ginny Ruffner and Dr. Jim Heath Explore the Intersection of Art and Science

    Renowned artist Ginny Ruffner and ISB President Dr. Jim Heath delivered a lecture at Town Hall Seattle about the intersection of art and science. They spoke about how creation stories tie scientists and artists together, and how their approaches are both similar and different from that point on.