ISB News
Profiles of Innovation: Lee Hood at Northeastern University
isbscience.org/news/2012/11/08/profiles-of-innovation-lee-hood-at-northeastern-university/Our Lee Hood was the featured guest on Nov. 5 at Boston's Northeastern University for the Profiles in Innovation Presidential Speaker Series. You can read the accompanying news story here.
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ISB's Dr. Sui Huang Earns Funding to Tackle Cancer's Biggest Questions
ISB’s Professor Sui Huang, MD, PhD, has been announced by Cancer Research UK as a member of a global research team funded through its Grand Challenge competition — an international funding initiative that aims to answer some of the biggest questions facing cancer research.
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New ‘scientific wellness’ strategy could cut chronic illnesses and save money
“Scientific wellness” should be widely adopted as a health strategy to avoid chronic illnesses and reduce health care costs, said ISB co-founder Dr. Lee Hood, speaking at the “Schrödinger at 75 conference” on the future of biology, in Dublin. Hood’s presentation was covered by The Irish Times.
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Igniting Curiosity, Catalyzing Change
At the 6th Annual Valerie Logan Luncheon held Thursday, the day’s theme – “Igniting Curiosity, Catalyzing Change” – was evident throughout. Every year, ISB celebrates Valerie Logan, the founder of our education programs, and all her work toward providing K-16 professional development for educators, high school STEM curriculum development, undergraduate research internships, and, crucially, student access to diverse mentors. This year’s event raised a record $140,000 to fund ISB’s education programs.
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Genome Comparison Easier with ‘Fingerprint’ Method
ISB researchers have developed a method of capturing a personal genome as a “fingerprint,” which will have a major impact on how quickly and efficiently genome sequences are compared.
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ISB Annual Report: Catalyzing A Revolution
ISB’s compass has always been oriented toward the future. Even when we reflect on the past year for each annual report, it’s always through the lens of what’s on the horizon. We are remarkably consistent in that regard, which is in no small part due to our president Dr. Lee Hood, whose vision is perpetually a decade – at least – ahead of everyone else.
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ISB Artwork Featured On Cover of Nature Biotechnology
Institute for Systems Biology and Arivale “Pioneer 100 Study” is featured on the cover of August’s Nature Biotechnology. The artwork was created by ISB’s Associate Director of Communications Allison Kudla in collaboration with contributing author John C. Earls, software engineer in Hood/Price Lab.
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Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness
Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness. Personal, dense, dynamic data clouds enable novel insights into mechanisms of wellness and disease, new approaches to biomarker discovery, and the empowerment of individuals to enhance their own health.
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Summer Course Success
Among ISB’s core values is the belief that we have a responsibility to share what we know. To that end, ISB hosts an annual weeklong Systems Biology of Disease Summer Course to introduce the core concepts of systems biology and their application to systems biomedicine. The course demonstrates the importance of cross-disciplinary interactions for the success of systems biology programs. Participants include graduate students, postdoctoral fellows, biomedical researchers, educators and…
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Spotlight: Christine Pham
Christine Pham, 2016 ISB High School Intern, was accepted by WSU’s Honors College and was named a Distinguished Regents Scholar, which awarded her a four-year tuition scholarship. “ISB saw the potential in me when I had not realized it myself. Working with multiple mentors and lab partners fostered my growth as an individual. As I head to college with the hopes of pursuing an interdisciplinary subject, I will build upon…
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Best Ever Valerie Logan Lunch: $120K Raised
The 5th Annual Valerie Logan Luncheon, which took place on Nov. 29, was our most successful yet, having raised $120,000 for ISB’s education programs. There were a few tear-jerker moments, including when Lee Hood interviewed some students: Sara Michelassi, who will graduate next spring with her high school diploma AND her AA in science from North Seattle College, said that she’s always dreamed of working in a lab, “but I…
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Logan Center for Education Hosts NGSS Workshop for Principals
ISB’s Logan Center for Education hosted a workshop on Next Generation Science Standards for principals from Puget Sound area schools. Kim Klinke, of the Logan Center, is also a LASER Alliance Director. She led the workshop, which gave principals an opportunity to learn about NGSS and “3-D teaching.”
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Ruth West Presents at ISB
When: Thursday, October 20, 12-1 pm Where: Institute for Systems Biology, Main Floor Auditorium, 401 Terry Ave North What: Ruth West will present her pioneering research practice at the intersections of art, science and media. This event is made possible through the Consilience program at ISB and is free and open to the public. Ruth West is in Seattle to exhibit her work ATLAS in silico as part of the…
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Dr. Lee Hood Signs Code.org Support Letter for WA House Bill 1813
Local business, tech and education leaders – including ISB President Dr. Lee Hood – signed a letter of support for House Bill 1813. From the recent Geekwire.com article: “The letter, sent by Code.org and Washington STEM today to leadership in the state House of Representatives, calls on legislators to support passing and funding House Bill 1813, which establishes a grant program with a private match requirement to both train educators in,…
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Talking STEM Education with the Rev. Jesse Jackson
It’s a fine day when the Rev. Jesse Jackson is the surprise guest speaker – after Gov. Jay Inslee – at an event. Dana Riley Black, Director of ISB’s Logan Center for Education, had the opportunity to meet the Rev. Jesse Jackson after his speech during the Washington STEM Summit, which is an annual event to bring education, business and community leaders together for a statewide effort to advance excellence,…
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Let Us Tell You Everything We Know About Proteomics – Everything
3 Bullets: Proteomics experiments generate huge amounts of raw data, most of which cannot be easily shared or described in a publication. ISB researchers curate publicly accessible databases that allow researchers to share their data with the world and to use data others have collected. All data are analyzed in a consistent manner and results are presented via searchable, user-friendly web applications. By Dr. Kristian Swearingen Institute for Systems Biology…
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Around the World with Lee Hood: Helsinki Lecture on 100K Wellness Project
ISB president, Dr. Lee Hood, gave the inaugural talk for the Academic Medical Center Helsinki Distinguished Lecture Series on Nov. 11, 2014, in Helsinki, Finland. He also received a lecture award. Read about the lecture here.
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ISB Gets $2.3 million NIH Grant to Use Single-Cell Technology to Fight Cancer
Pictured above: Dr. Qiang Tian, left, and Dr. Edward Lin, right, discuss single-cell analysis technologies developed at Institute for Systems Biology in Seattle. September 22, 2014 – ISB has received a $2.3 million NIH grant over four years in response to NCI’s “Provocative Questions” Initiative. The project will apply ISB’s most advanced single-cell omics technologies to an innovative clinical trial for colorectal cancer (ADAPT). Principal investigator Qiang Tian, MD, PhD,…
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Lee Hood Receives IEEE Medal for Innovations in Healthcare Technology
Dr. Lee Hood received the IEEE Medal for Innovations in Healthcare Technology at a ceremony in Amsterdam on Aug. 23, 2014. Please watch a video of his acceptance speech here. IEEE Spectrum Magazine also published an article featuring an interview with Lee: “Medicine’s Next Big Mission: Understanding Wellness” Read article…
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Tracking Cells from Well to Diseased
KUOW's Marcie Sillman and producer Amina Al-Sadi interviewed Dr. Lee Hood about P4 medicine and the 100K Wellness Project. This 29-minute recording is a great conversation about Lee's vision for how to turn healthcare on its head. Listen to the podcast. Learn more about the 100K Wellness Project.
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New $10.9 Million Grant from NIH
The NIH's National Institute of General Medical Sciences has issued a Biotechnology Resource Grant of $10.9 million over five years to the National Center for Dynamic Interactome Research (ncdir.org) project. This project is a collaboration among The Rockefeller University, Institute for Systems Biology, Seattle BioMed, University of California at San Francisco, New York University and New York Structural Biology Center. Michael Rout, of The Rockefeller University, is the Program Director/Principal…
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ISB’s 2013 Annual Report is Now Available
Institute for Systems Biology has a dizzying breadth of research projects. But when we talk about what we do, it’s how we do it that matters most. The systems approach that we pioneered and exemplify continues to distinguish our ability to tackle the most complex biological and environmental challenges today. Because of how we apply our hallmark collaborative, cross-disciplinary and integrative approach, our collective success is greater than the sum…
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3-Minute Science: ISB and Seattle BioMed Hold Annual Lightning Talks
Photo: Theo Knijnenburg, a research scientist in ISB's Shmulevich Lab, presentaed a summary of his work related to gene mutations and cancer drug sensitivity. Systems biology is about the culture as much as a scientific approach. ISB and Seattle BioMed have an inter-institutional agreement that enables the collective to benefit from shared knowledge and technology resources. For the second consecutive year, we held Lightning Talks (June 12) to allow researchers…
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Shifting the Education Paradigm
Photo above: Dr. Vineet Sangar, right, a postdoc in the Price Lab at ISB, explains proteomics technology to a group of community college faculty, who participated in a systems biology workshop in May 2014. By Dana Riley Black Director of Logan Center for Education Over the past two decades, systems biology has revolutionized traditional approaches to answering complex biological questions. The rapid advancement of computational power and the increased access…
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ISB’s K-12 STEM Education Work: Collaboration with Washington Alliance for Better Schools
(Photo: Bothell High School teacher Cynthia McIntyre (above left) and ISB’s Chris Plaisier (above right), a senior research scientist in the Baliga Lab, participated in Washington Alliance for Better Schools’ event “A Celebration of STEM” which took place MOHAI on May 6.) ISB’s K-12 STEM Education work On May 6, Washington Alliance for Better Schools held “A Celebration of STEM” at MOHAI to showcase projects that middle and high school…
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Lee Hood Wins IEEE Medal for Innovations in Healthcare Technology
IEEE (Institute of Electrical and Electronics Engineers) announced that Dr. Lee Hood, president of Institute for Systems Biology, is the 2014 recipient of the Medal for Innovations in Healthcare Technology. He is being recognized for "pioneering contributions to DNA sequencing technologies that revolutionized life and health sciences." Read about all the medal recipients here.
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Data Vis Meetup Held at ISB
Pictured above: Allison Kudla presents ISB’s Big Data Science site at the start of the meetup. ISB hosted the Seattle Vis meetup group this past Wednesday (April 30). The meetup was organized by Noah Iliinsky and facilitated by ISB’s Dick Kreisberg. The guest speakers were Ryan Lucas and Kevin Lynagh, who have created a very stylistic charting library based on a grammar of graphics. They are an independent data vis…
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Systems Biology + Systems Art
(Photo above: Artist Xiao Dong Feng and Dr. Lee Hood raise a toast during a reception on April 28. Feng’s painting “Qing Xu” hangs in the background. The name is symbolic of someone who eschews earthly materialism and is instead a visionary who seeks a higher or more spiritual understanding.) On April 28, Institute for Systems Biology hosted an intimate symposium on Systems Biology & Systems Art in honor of…
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ISB’s Annual Symposium
ISB held its 13th Annual International Symposium: Systems Biology & Cancers From Big Data to Personalized Treatment on April 13-14, 2014. Visit symposium.isbscience.net for details. Visit the gallery for images. Or visit the video playlist on ISB’s YouTube channel.
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Now researchers can explore genomic data across space and time
The figure above is part of a four-step procedure for the multiscale segmentation of genomic signals. 3 Bullets: Understanding systems from a multiscale perspective gives us a more detailed and holistic view of how features or functions from each scale connect and interact in a given system. The challenge is integrating the different types of information that come from each scale in an efficient way that yields the most insight….
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ISB’s Robert Moritz Lab Receives NIGMS Grant for Trans Proteomic Pipeline
The National Institute Of General Medical Sciences of the NIH has awarded Principal Investigator(s): Eric Deutsch, PhD, and Robert L. Moritz, PhD, a continuing R01 grant GM087221 for the ongoing development of the Trans-Proteomic Pipeline. The award titled “Development of Trans Proteomic Pipeline, an Analysis Suite for Mass Spectrometry” will continue the work of the ISB flagship proteomics analysis suite of open-source programs that has been downloaded thousands of times…
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Summer Course Registration Is Now Open!
Summer Course: Systems Biology of Disease Register Now Offered by Institute for Systems Biology and Center for Systems Biology Course Objective The goal of this course is to introduce the core concepts of systems biology and their application to systems biomedicine. We will demonstrate the importance of cross-disciplinary interactions for the success of systems biology programs. When July 28 – August 1, 2014 9 am to 5 pm Where Institute…
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Mark Calendars for Dr. Lee Hood’s Reddit AMA on April 11
Dr. Lee Hood will participate in a Reddit AMA (Ask Me Anything) on March 24 April 11 from 10-11 a.m. PST. There will be more details posted on Reddit.com the morning of April 11. For now, feel free to look at the list of upcoming science AMAs or check out some previous science AMAs here.
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ISB’s Trans Proteomic Pipeline Software in Demand
Luis Mendoza and Eric Deutsch, of the Moritz lab, were at CINVESTAV (a federal institute in Irapuato, Mexico) last week to teach a workshop on the Trans-Proteomic Pipeline software. From Luis (pictured above): "We covered the basics of data analysis of tandem mass spectrometry data using the TPP, including the justification and theory behind the methods as well as interpretation of the results via hands-on tutorials. We had a full…
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ISB Has Two New Patents
2014 is off to a great start for innovation in human health. ISB released two new patents in January that will make great contributions to personalized medicine. One of the patents, issued on January 27 and titled Use of Gene Expression Signatures to Determine Cancer Grade, has ISB President Dr. Lee Hood and ISB Senior Research Scientist Qiang Tian listed as inventors. Also sharing in that patent is Xiaowei Yan…
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Science Education Impact
The educators who work at ISB continue to influence how science is taught in the State of Washington. Claudia Ludwig and Dina Kovarik, members of the Baliga Lab education team, recently helped the Highline School District apply for a $1,000 grant to use toward systems science materials and teacher training. Highline’s Arts and Academics Academy received the award, which will also provide students with “real-world” lab experience.
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Innovation Game Changer: Lee Hood
Dr. Lee Hood appeared in a video series produced by World Free From Cancer and Value of Innovation about five "game changers" who will help make this a cancer-free world.
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Lee Hood at World Stem Cell Summit
Genetic Engineering & Biotechnology News offered some highlights from the World Stem Cell Summit, where ISB president, Dr. Lee Hood, gave today's keynote talk: “In 5 to 10 years, you will have your genomes as part of your medical records,” Leroy Hood, M.D., Ph.D., Institute for Systems Biology, told attendees of the World Stem Cell Summit 2013 today, in San Diego. “Third-generation sequencing will be revolutionary,” he said in his…
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ISB Hosts 2nd Annual Valerie Logan Luncheon on Nov. 13
Photo above: Valerie Logan during the 2012 Valerie Logan Luncheon. To inspire students and imbue them with a love for science, technology, engineering and math (STEM), we must inspire their teachers. ISB has always held this philosophy and, at the 2nd Annual Valerie Logan Luncheon on Nov. 13, we will celebrate our vision for bringing quality STEM education to all students and also honor Dr. Meena Selvakumar as the recipient…
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Lee Hood Selected To Receive Research!America’s 2014 Geoffrey Beene Builders of Science Award
Research!America Honors Leaders in Medical and Health Research Advocacy Glenn Close, Dr. Leroy Hood, Dr. Reed Tuckson, Kathy Giusti and the Progeria Research Foundation to Receive 2014 Research!America Advocacy Awards “This year’s honorees have transformed the lives of many individuals across the country through their remarkable achievements and advocacy for medical and health research,” said Mary Woolley, president and CEO of Research!America. “Their unwavering dedication is helping to elevate research in…
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Lee Hood Among Featured Innovators at Bezos Center for Innovation at MOHAI
On Oct. 11, MOHAI hosted a VIP event to celebrate the launch of the Bezos Center for Innovation. The exhibit features 13 innovators from the Seattle area, including ISB’s president, Dr. Lee Hood. Each innovator sat for an interview and snippets from each interview are woven throughout the exhibit on touchscreens. Event attendees included Dennis Hayes, below left, who founded Earth Day. He and Lee Hood, below right, spent a…
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Greater Good: Successful High School Interns
Every summer, ISB welcomes a group of high school interns, hosted through our Systems Education Experiences program. ISB is proud of its collaborative and cross-disciplinary culture and we work hard to nurture an environment that allows our staff to achieve at a high level. It was especially gratifying to get this comment from one of our interns, who had just completed her time here: “At ISB, I witnessed collaboration that…
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UW’s Four Peaks TV: Dr. Lee Hood Speaks About Innovation
Episode: Wellness and Science Pioneer From Four Peaks: May 24, 2013 Dr. Leroy Hood says we may not recognize our healthcare system a decade from now. Innovation will make it more predictive, personalized, preventative and participatory — his four Ps. And through Dr. Hood’s systems-based approach, we’ll be focused far more on “wellness” than on “care.” That’s just one reason why he was recognized by President Obama with one of…
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ISB K-12 Science Education Team Helps ‘STEM’ School Develop Curriculum
Riverpoint Academy in Spokane has been working with ISB’s K-12 science education team to develop curriculum that falls under “STEM” – science, technology, engineering and math. Riverpoint describes itself as a STEM school that also teaches arts, humanities and entrepreneurship. Some educators and administrators from Riverpoint and the Mead School District, as well as other community leaders visited ISB on May 3 and 4 to participate in a workshop to…
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Systems Biology and Systems Medicine Curriculum in Middle and High Schools?
By Dana Riley Black, Director of ISB’s Center for Inquiry Science Healthcare continues to be listed as a “high-demand” field, meaning there continue to be significant and projected employment opportunities in the field. A recent employment gap analysis by Washington State released on April 3 suggests a projected deficit of 472 healthcare jobs filled annually in the state (see: http://www.wtb.wa.gov/HighDemandFields.asp). As a result, many middle and high schools are turning…
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ISB at Startup Weekend
Several ISB staffers participated in Startup Weekend UW on Jan. 25-27. Graduate student Karlyn Beer and software engineer Wei-Ju Wu, both of the Baliga Group, pitched PoorMe.co, a public health social network. Steven Lewis, a software engineer in the Shmulevich Group, was part of team PerFit, which is an app that creates a 3D body scan so that you can virtually try on clothes online. Read about Steven’s experience at…
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Dr. Lee Hood Receives National Medal of Science
Above: Dr. Lee Hood and members of his lab group raise a very Seattle toast with Starbucks coffee to celebrate. On Dec. 21, 2012, the White House announced that Dr. Lee Hood, ISB’s president and co-founder, is a recipient of the 2012 National Medal of Science. This is the highest honor the U.S. President can bestow upon scientists. “This is exciting because it’s for lifetime achievement,” Lee commented, “which lauds all…
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National Academy of Inventors 2012 Charter Fellow: Dr. Lee Hood
This is the press release from the National Academy of Inventors: National Academy of Inventors announces 2012 NAI Charter Fellows 98 academic inventors and innovators elected to high honor TAMPA, Fla. (Dec. 18, 2012)—The National Academy of Inventors (NAI) has named 98 innovators to NAI Charter Fellow status, representing 54 prestigious research universities and non-profit research institutes. Together, the new Fellows hold more than 3,200 U.S. patents. Included in the…
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ISB Co-Authored Nature Paper Featured in the New York Times
The Ilya Shmulevich Group at ISB has been participating in The Cancer Genome Atlas (TCGA) project as a Genome Data Analysis Center. The first paper resulting from the main phase of the TCGA project – "Comprehensive molecular characterization of human colon and rectal cancer" – was published in the July 19, 2012, issue of Nature and also featured on the front page of the New York Times. ISB teamed up…
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ISB Featured in Google I/O Conference Keynote
We were very excited to watch the live stream of the keynote from the Google I/O conference today, because it featured work from ISB's Shmulevich Lab, which is one of a group of research organizations that has been working on The Cancer Genome Atlas (TCGA). To help visualize the TCGA data, the lab created the Cancer Regulome Explorer using Google App Engine and Google Compute Engine. Google Compute Engine is…
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ISB Innovation in Action
Above: Kristian Swearingen and the re-engineered FAIMS device. (Editor's Note: This post shows a wonderful example of the collaborative, innovative and entrepreneurial ethic that ISB nurtures. Even if the science or technology is difficult to explain concisely, the cross-disciplinary and integrative nature of how our work is done and the pioneering spirit come through. How cool is that?) By Terry Farrah What do you do when your mass spectrometer accessory…
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Dr. Leroy Hood Talks P4 at Inova Fairfax Hospital
Dr. Leroy Hood spoke at Inova Fairfox Hospital in Falls Church, Virginia, on March 27. His talk focused on P4 medicine. The Washington Business Journal covered the event. The following video is courtesy of Inova.
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Watch Cracking Your Genetic Code on PBS. See more from NOVA.
Lee Hood Talks Actionable Genes in NOVA’s ‘Cracking Your Genetic Code’
If you missed the NOVA special "Cracking Your Genetic Code" you can watch it here. Our president, Lee Hood, was among the experts featured in the documentary.
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Genome Ethics
By Chris Witwer The Health and Human Service human research regulations are being revised. Scientists' input on whole genome sequencing data may shape the future of research. It's great that the article below says that change is "imminent." Here's an article that describes the issue: DNA Mapped in a Day Prompts U.S. Review of Genome Ethics And here's a document from the Department of Health and Human Services: https://s3.amazonaws.com/public-inspection.federalregister.gov/2012-07329.pdf The…
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Watch Cracking Your Genetic Code Preview on PBS. See more from NOVA.
Lee Hood on NOVA on March 28
We are eager to watch the NOVA documentary tonight on PBS called "Cracking Your Genetic Code." Lee Hood is one of the featured experts. The producer, Sarah Holt, began with a series of phone interviews late last summer before interviewing Lee on camera in her Boston studio. Here's a preview radio segment on the Emily Rooney Show that features Holt and Dr. Rudy Tanzi, who also appears in the documentary….
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PopSci Future of: Preventive Medicine
This video from 2009 is a fun one of Dr. Leroy Hood's appearance on the Science Channel's "PopSci's Future of" show. It explains in simple terms why our researchers are looking for protein biomarkers, which offer the earliest signs of disease.
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Personalized Medicine: From Bench to Clinic
Our president, Dr. Leroy Hood, is featured in this Genome Technology article about the challenges of moving personalized medicine into the clinic. (The cover image features Dr. Eric Topol, who recently published a book called "The Creative Destruction of Medicine.")
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Medicine 2.0: A Digital You
Dr. Eric Topol was a guest on KUOW/NPR this morning to discuss his new book "The Creative Destruction of Medicine" which talks about how the digital revolution can dramatically change healthcare and the practice of medicine. When we talk about P4 Medicine, we encourage people to understand – and embrace – the technology that's already available and the promise of a future when doctors will know exact data about your…
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Even Our Interns Are Rock Stars
Gordon Sun is an intern in Rob Moritz's lab. His mother, Sarah Li, is a research associate in the Moritz group. Gordon is a semifinalist in the Intel Science Talent Search and Natasha Ryan from KING-TV is interviewed him. Congratulations to all! Watch the interview:
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Inspiring Future Scientists
Our president, Lee Hood, has always been committed to K-12 science education. When heard that a group of elementary school children were coming to ISB to take a tour, he made sure to take the time to speak to them.
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Dr. Leroy Hood: ‘Biological Complexity Under Attack’
Dr. Leroy Hood wrote this piece about systems biology and big science for Genetic Engineering & Biotechnology News. Read the article. "This is a truly remarkable time in the biological sciences. Biology now has the opportunity to effectively attack some of the most fundamental problems of society, including healthcare, agriculture, bio-energy, a sustainable environment, and nutrition. "These opportunities are a result of system strategies for probing biological complexity, emerging technologies…