Pop quiz: What’s the difference between DNA, RNA and proteins? ISB researchers have created a video game that teaches secondary students (grades 6-12) the key tenets of molecular biology in a fun, interactive and engaging way, and can be used by teachers as a supplemental aide to assist with complex lessons.
In a multi-institutional study of a highly infectious disease like COVID-19, paperless consent for study participants is critical. One component of the COVID-19 Immune Response Study is a recruitment website with an IRB-approved and HIPAA-compliant electronic consent platform for enrolling patients.
ISB researchers have developed a method of capturing a personal genome as a “fingerprint,” which will have a major impact on how quickly and efficiently genome sequences are compared.
3 Bullets: Proteomics experiments generate huge amounts of raw data, most of which cannot be easily shared or described in a publication. ISB researchers curate publicly accessible databases that allow researchers to share their data with the world and to use data others have collected. All data are analyzed in a consistent manner and results are presented via searchable, user-friendly web applications. By Dr. Kristian Swearingen Institute for Systems Biology…
Dr. Lee Hood received the IEEE Medal for Innovations in Healthcare Technology at a ceremony in Amsterdam on Aug. 23, 2014. Please watch a video of his acceptance speech here. IEEE Spectrum Magazine also published an article featuring an interview with Lee: “Medicine’s Next Big Mission: Understanding Wellness” Read article…
The NIH's National Institute of General Medical Sciences has issued a Biotechnology Resource Grant of $10.9 million over five years to the National Center for Dynamic Interactome Research (ncdir.org) project. This project is a collaboration among The Rockefeller University, Institute for Systems Biology, Seattle BioMed, University of California at San Francisco, New York University and New York Structural Biology Center. Michael Rout, of The Rockefeller University, is the Program Director/Principal…
Institute for Systems Biology has a dizzying breadth of research projects. But when we talk about what we do, it’s how we do it that matters most. The systems approach that we pioneered and exemplify continues to distinguish our ability to tackle the most complex biological and environmental challenges today. Because of how we apply our hallmark collaborative, cross-disciplinary and integrative approach, our collective success is greater than the sum…
Photo: Theo Knijnenburg, a research scientist in ISB's Shmulevich Lab, presentaed a summary of his work related to gene mutations and cancer drug sensitivity. Systems biology is about the culture as much as a scientific approach. ISB and Seattle BioMed have an inter-institutional agreement that enables the collective to benefit from shared knowledge and technology resources. For the second consecutive year, we held Lightning Talks (June 12) to allow researchers…
IEEE (Institute of Electrical and Electronics Engineers) announced that Dr. Lee Hood, president of Institute for Systems Biology, is the 2014 recipient of the Medal for Innovations in Healthcare Technology. He is being recognized for "pioneering contributions to DNA sequencing technologies that revolutionized life and health sciences." Read about all the medal recipients here.
Pictured above: Allison Kudla presents ISB’s Big Data Science site at the start of the meetup. ISB hosted the Seattle Vis meetup group this past Wednesday (April 30). The meetup was organized by Noah Iliinsky and facilitated by ISB’s Dick Kreisberg. The guest speakers were Ryan Lucas and Kevin Lynagh, who have created a very stylistic charting library based on a grammar of graphics. They are an independent data vis…
ISB held its 13th Annual International Symposium: Systems Biology & Cancers From Big Data to Personalized Treatment on April 13-14, 2014. Visit symposium.isbscience.net for details. Visit the gallery for images. Or visit the video playlist on ISB’s YouTube channel.
The figure above is part of a four-step procedure for the multiscale segmentation of genomic signals. 3 Bullets: Understanding systems from a multiscale perspective gives us a more detailed and holistic view of how features or functions from each scale connect and interact in a given system. The challenge is integrating the different types of information that come from each scale in an efficient way that yields the most insight….
The National Institute Of General Medical Sciences of the NIH has awarded Principal Investigator(s): Eric Deutsch, PhD, and Robert L. Moritz, PhD, a continuing R01 grant GM087221 for the ongoing development of the Trans-Proteomic Pipeline. The award titled “Development of Trans Proteomic Pipeline, an Analysis Suite for Mass Spectrometry” will continue the work of the ISB flagship proteomics analysis suite of open-source programs that has been downloaded thousands of times…
Luis Mendoza and Eric Deutsch, of the Moritz lab, were at CINVESTAV (a federal institute in Irapuato, Mexico) last week to teach a workshop on the Trans-Proteomic Pipeline software. From Luis (pictured above): "We covered the basics of data analysis of tandem mass spectrometry data using the TPP, including the justification and theory behind the methods as well as interpretation of the results via hands-on tutorials. We had a full…
Our Lee Hood was the featured guest on Nov. 5 at Boston's Northeastern University for the Profiles in Innovation Presidential Speaker Series. You can read the accompanying news story here.
The Ilya Shmulevich Group at ISB has been participating in The Cancer Genome Atlas (TCGA) project as a Genome Data Analysis Center. The first paper resulting from the main phase of the TCGA project – "Comprehensive molecular characterization of human colon and rectal cancer" – was published in the July 19, 2012, issue of Nature and also featured on the front page of the New York Times. ISB teamed up…
We were very excited to watch the live stream of the keynote from the Google I/O conference today, because it featured work from ISB's Shmulevich Lab, which is one of a group of research organizations that has been working on The Cancer Genome Atlas (TCGA). To help visualize the TCGA data, the lab created the Cancer Regulome Explorer using Google App Engine and Google Compute Engine. Google Compute Engine is…
Above: Kristian Swearingen and the re-engineered FAIMS device. (Editor's Note: This post shows a wonderful example of the collaborative, innovative and entrepreneurial ethic that ISB nurtures. Even if the science or technology is difficult to explain concisely, the cross-disciplinary and integrative nature of how our work is done and the pioneering spirit come through. How cool is that?) By Terry Farrah What do you do when your mass spectrometer accessory…
