ISB News

Former Undergrad Intern Publishes Algorithm in PLOS Computational Biology

William Poole, 2013 undergrad intern

Posted March 1, 2017

In a study published in PLoS Computational Biology, researchers at Institute for Systems Biology (ISB) have developed a multiscale mutation clustering algorithm (M2C) that identifies variable length regions with high mutation density in cancer genes. The M2C algorithm was developed by William Poole (first author on the paper), who started as a summer intern in 2013 as part of ISB’s Center for Systems Biology internship program. Working under the guidance of Dr. Brady Bernard and Dr. Theo Knijnenburg, both senior research scientists in the lab of Ilya Shmulevich at ISB, Poole’s initial summer internship led to a multi-year project that resulted not only in this PLoS Computational Biology publication, but also a Bioinformatics publication about combining dependent P-values. His work was presented at two international scientific conferences: the TCGA Scientific Symposium 2015 and The 15th European Conference on Computational Biology (ECCB 2016). Currently, Poole is pursuing a PhD at the California Institute of Technology (Caltech) in Pasadena, California.

READ FULL SUMMARY OF PAPER

Recent Articles

  • View of the responsive recruitment website and electronic consent platform as seen on mobile phone and desktop devices.

    ISB Builds Digital Platform for COVID-19 Research Study – and Beyond

    In a multi-institutional study of a highly infectious disease like COVID-19, paperless consent for study participants is critical. One component of the COVID-19 Immune Response Study is a recruitment website with an IRB-approved and HIPAA-compliant electronic consent platform for enrolling patients.

  • Reshaping STEM Education Toward a More Equitable Future for Students

    ISB Assistant Professor Dr. Sean Gibbons recently participated in a virtual event titled “Reshaping STEM Education Toward Equitable Futures for Washington Students.” Panelists shared their insights about how to leverage this complex moment to reshape STEM education toward equity, sustainability, and prosperity for Washington state’s students — especially those furthest from opportunity.

  • Shmulevich-Thorsson

    ISB Researchers Among Recipients of AACR Team Science Award

    The American Association for Cancer Research (AACR) has recognized The Cancer Genome Atlas (TCGA) project with the 2020 AACR Team Science Awards. Award recipients include Dr. Ilya Shmulevich, ISB professor and head of the Shmulevich Lab; ISB senior research scientist Dr. Vésteinn Þórsson; and former Shmulevich Lab members Drs. Brady Bernard and Theo Knijnenburg.