ISB News

Former Undergrad Intern Publishes Algorithm in PLOS Computational Biology

William Poole, 2013 undergrad intern

Posted March 1, 2017

In a study published in PLoS Computational Biology, researchers at Institute for Systems Biology (ISB) have developed a multiscale mutation clustering algorithm (M2C) that identifies variable length regions with high mutation density in cancer genes. The M2C algorithm was developed by William Poole (first author on the paper), who started as a summer intern in 2013 as part of ISB’s Center for Systems Biology internship program. Working under the guidance of Dr. Brady Bernard and Dr. Theo Knijnenburg, both senior research scientists in the lab of Ilya Shmulevich at ISB, Poole’s initial summer internship led to a multi-year project that resulted not only in this PLoS Computational Biology publication, but also a Bioinformatics publication about combining dependent P-values. His work was presented at two international scientific conferences: the TCGA Scientific Symposium 2015 and The 15th European Conference on Computational Biology (ECCB 2016). Currently, Poole is pursuing a PhD at the California Institute of Technology (Caltech) in Pasadena, California.

READ FULL SUMMARY OF PAPER

Recent Articles

  • COVID-19 Vaccines and Boosters Are Essential for Maternal-Fetal Health

    In light of the recent FDA and CDC decision to approve two updated messenger RNA COVID-19 booster shots, it is imperative to alert the pregnant population of the importance and effectiveness of these vaccines and boosters. 

  • Spotlight on ISB Education graphic

    2022-23 School Year ISB Education Highlights

    From planning, creating and executing workshops for educators to forging new relationships to elevate students, the ISB Education team has been in high gear. Each month throughout the 2022-2023 academic year, we will highlight some of the top projects the team is working on.

  • 2023 ISB Virtual Microbiome Series

    2023 ISB Virtual Microbiome Series Registration Now Open!

    On October 11-13, 2023, ISB will host a virtual course and symposium on how the ecology of our guts protects us from pathogens. Both events are virtual and free. The intended audience for these events are graduate students, postdocs, principal investigators, industry scientists, educators, clinicians, or any other variety of microbiome-curious person from across the globe.