ISB News

New Study: Using Single-Cell Technology to Predict Cell Behavior

In a study published in PLOS BIOLOGY, researchers at Institute for Systems Biology (ISB) explain how they developed a new theory for predicting cell-fate decisions and demonstrate, for the first time, that cells indeed undergo a critical transition – or tipping point – when they commit to a particular lineage.

Jan. 9, 2017

3 Bullets:

  • ISB researchers developed a new theory that uses state-of-the-art single-cell technology to make predictions about how cells will behave in the future.
  • The method can predict when a cell will experience a so-called tipping point before it happens.
  • Being able to predict these critical transitions in cells may have life-saving ramifications in the ability to detect early warning signals for disease.

By Dr. Sui Huang

Stem cells hold enormous potential for cell-based therapy in regenerative medicine, if we can use drugs in the lab to push the patient’s own stem cells to become desired cell types, such as blood, liver, or heart cells. So far, our successes in controlling the generation of specific cell types have been empirical. Researchers have painstakingly mapped out many of the genes involved in the cell-fate-decision processes. But we still have little clue about the fundamental principles that govern how a multipotent stem cell, which has the potential to become more than one type of cell, makes a decision to become a specific cell type. We have not had a formal theory for such cell-fate decisions – until now.

In a study published in PLOS BIOLOGY, researchers at Institute for Systems Biology (ISB) explain how they developed a new theory for predicting cell-fate decisions and demonstrate, for the first time, that cells indeed undergo a critical transition – or tipping point – when they commit to a particular lineage. The team designed a new computational approach that utilizes single-cell resolution gene-expression profiling data to compute an index that indicates an imminent tipping point in cells before it happens. READ MORE….

Recent Articles

  • Drs. Jennifer Hadlock and Alexandra Ralevski

    ISB Study Highlights AI’s Potential and Pitfalls in Analyzing Health Data

    New peer-reviewed research out of ISB highlights the strengths of large language models in uncovering social determinants of health while underscoring the need for human oversight and improved de-identification methods.

  • Dr. Sid Venkatesh

    Sid Venkatesh Publishes Co-First Authored Paper in Science

    ISB Assistant Professor Dr. Sid Venkatesh is the co-first author of a paper in the journal Science. While at Washington University in St. Louis, Venkatesh and colleagues identified a novel gut microbial enzyme that impacts satiety-related signaling pathways in undernourished children treated with microbiota-directed complementary foods.

  • AmeriCorps Member Faduma Hussein Joins ISB as Public Health Ambassador Coordinator

    Faduma Hussein recently joined the ISB Education team as the Public Health Ambassador Coordinator, becoming only the fourth AmeriCorps member to serve at ISB. In this Q&A, she shares insights into her education, what drew her to ISB, career aspirations, and more.