Research

The following headlines link to summaries of research published in recent years. Using the filters in the navigation bar, you can filter the summaries by research area, disease or lab group.

  • Pregnancy Health, from Bench to Bedside

    We are running a feasibility study, in partnership with Magee-Womens Health, to tease out the intricacies of pregnancy as it progresses from conception to postpartum.

  • Placenta and Preterm Birth

    ISB is using systems biology to map molecular network dynamics in normal pregnancy, as well as study changes that occur in pregnancies with complications such as preterm birth. By using a systems approach, we hope to gain a more comprehensive understanding of pathological changes that occur in pregnancy, and identify women most at risk of developing pregnancy complications.

  • Method Developed to Profile Pathogen Gene Expression from Infected Host Cells

    The rise in multi-drug resistant and extremely drug resistant strains of Mycobacterium tuberculosis has become a major cause of global health concern for treating tuberculosis. ISB researchers developed Path-seq, a method that profiles host and pathogen gene expression and can explore the pathogen transcriptome in vivo.

  • brain

    Brain Health

    ISB, along with a collaborative network of partners, is pioneering a multimodal approach that combines personal data, lifestyle factors, cognitive training and systems medicine — and is rigorously testing these new approaches in clinical trials. This approach is critical to prevent, slow, and even reverse many neurological conditions before they become irreversible.

  • Wilke Cohen Lyme Disease Project

    ISB researchers have put their efforts into looking at Lyme disease and the bacteria, Borrelia burgdorferi, that causes the disease, through the lens of systems biology, and utilizing approaches pioneered at ISB to gather, synthesize and interpret large and complex datasets.

  • Stress Test Predicts How Diatoms Will React to Ocean Acidification

    The foundation of many marine food webs in which corals, fish and whales depend on are microscopic photosynthetic algae called diatoms. ISB scientists have developed a stress test to quantify and predict how ocean acidification would impact the resilience of diatoms in the future.

  • Genome fingerprinting

    Ultrafast Comparison of Personal Genomes

    Genome sequences contain information with immense possibilities for research and personalized medical care, but their size, complexity and diversity make comparing sequences error-prone and slow. ISB researchers have created a method for summarizing a personal genome as a “fingerprint.”

  • P100 Cover

    Pioneer 100 Study Establishes Foundation for New Industry of Scientific Wellness

    Results from the Pioneer 100 Wellness Project, a nine-month study of 108 individuals, demonstrated that combining personal, dense, dynamic data clouds with tailored behavioral coaching can optimize wellness for individuals. These data clouds also can identify early transitions into disease states and facilitate the reversal of some disease states back to wellness.

  • Warhol style Plasmodium

    Identification of the proteins in Plasmodium vivax provide new targets for a malaria vaccine

    Scientists from ISB and the Center for Infectious Disease Research led an international collaboration to identify proteins in the malaria parasite Plasmodium vivax. P. vivax and P. falciparum cause the majority of malaria cases, but P. vivax is far less-studied, in part because it cannot be grown in the lab. The research aims to provide new targets for a malaria vaccine.

  • Adaptive Prediction of Yeast

    How Microbes Learn to Predict the Future

    Like plants and animals, even microbes can anticipate and prepare in advance for future changes in their environment
    Similar to how Pavlov trained a dog to anticipate food when it heard a bell, ISB researchers trained yeast to anticipate a lethal toxin when it sensed caffeine
    The study revealed how in a very short period of time yeast can evolve to ‘learn’ and ‘predict’ new patterns in their environment

  • TCGA Researchers Identify Potential Drug Targets for Leading Form of Deadly Liver Cancer

    ISB researchers and colleagues from TCGA Research Network performed the first large-scale, multi-platform analysis of hepatocellular carcinoma, the predominant form of liver cancer. Such integrated analyses enabled the identification of potential therapeutic targets and facilitated biological insights that would not have been possible otherwise.

  • A Cell-Surface Membrane Protein Signature for Glioblastoma

    Using integrated protein and gene expression data, ISB researchers developed a 33-gene signature for glioblastoma, an aggressive form of brain cancer.

  • ISB Scientists Have Discovered When and Why a Microbial Community Might Collapse

    Researchers at Institute for Systems Biology have developed a framework for assessing the “health” of a microbial community through a stress test that enables them to ask when and why microbial communities collapse under different environmental conditions.

  • Novel clustering algorithm identifies functional mutations in cancer genes

    In a study published in PLoS Computational Biology, researchers at Institute for Systems Biology (ISB) have developed a multiscale mutation clustering algorithm (M2C) that identifies variable length regions with high mutation density in cancer genes.

  • Mapping the early effects of the Huntington’s disease mutation in mice

    A multi-institute collaboration sought to map in high-resolution the earliest effects of the Huntington’s disease mutation in mice.

  • Predicting Cell Fate Decisions Using Single-Cell Analysis and the Theory of Tipping Points

    ISB researchers developed a new theory to exploit burgeoning single-cell molecular profiling measurements to make predictions of future cell behaviors.

  • Proteomics: Identifying Organ-Specific Blood Biomarkers for Acute Liver Injury

    To assess probable injury to an organ, it is important to monitor biologic materials that originate exclusively or primarily in that organ, in this case, liver-enriched proteins.

  • Quantitating the Complete Human Proteome

    ISB scientists collaborate with ETH Zurich to develop the Human SRMAtlas, a compendium of mass spectrometry assays for any human protein.

  • Stitching Together Insight For Deadly Brain Cancer Glioblastoma

    Using data from TCGA and ENCODE, ISB researchers developed an integrative database and analysis platform that provides insight into the underpinnings of glioblastoma multiforme, and identified a never before seen association between increased levels of immune molecules, tumor immune cell infiltration, and decreased patient survival.

  • Project Feed 1010 – Sustainable Agriculture

    ISB is actively working on Project Feed 1010, a demonstration project and laying the experimental, computational, cloud-computing and social networking infrastructure for a first-of-its-kind network of farmers, scientists and educators to crowdsource sustainable agriculture research and education.