gut microbiome Archives

Posted: April 21, 2025

Celebrating the Life and Legacy of Valerie Logan Hood

ISB is deeply saddened to share the passing of Valerie Logan Hood, beloved wife of ISB Co-founder and Professor Dr. Lee Hood. Her lifelong dedication to K-12 education helped create and shape ISB’s programs, and her influence will be felt for generations to come.

This circular workflow illustrates how personalized medicine is applied using the mmSYGNAL model. Starting with molecular profiling of a new patient, data are mapped to the mmSYGNAL network — originally built from a large patient cohort — and integrated with our MM knowledge base to generate a patient-specific disease network map. This map supports risk prediction and therapy matching, which are synthesized by a Clinical Decision Support Service to provide actionable insights for the treating physician, enabling tailored and informed treatment decisions.

Posted: April 2, 2025

New Model Transforms Multiple Myeloma Risk Prediction

A team of researchers has developed a powerful new tool that could transform how doctors treat multiple myeloma, a complex and often unpredictable blood cancer.

Sui Huang's illustration of cancer attractors on the epigenetic landscape

Posted: March 26, 2025

ISB’s Sui Huang Challenges the Genetic Paradigm of Cancer in New Essay

Sui Huang challenges the prevailing view of cancer as purely genetic in a new essay published in PLOS Biology. Huang and colleagues suggest non-genetic factors and disrupted gene regulatory networks may play crucial roles in cancer development.

Posted: March 20, 2025

Melanoma Starts Evading Treatment Within Hours – Here’s How to Stop It

ISB researchers have uncovered a stealth survival strategy that melanoma cells use to evade targeted therapy, offering a promising new approach to improving treatment outcomes.

Posted: February 18, 2025

Scientists Decode Diet From Stool DNA – No Questions Asked

ISB’s Gibbons Lab developed a breakthrough method that analyzes food-derived DNA in fecal metagenomes, allowing for data-driven diet tracking without the need for burdensome questionnaires.

Posted: February 10, 2025

Carole Ellison’s Bold Bet on Science and the Researchers of Tomorrow

Carole Ellison has supported ISB’s research and STEM programs for over a decade. She established the K. Carole Ellison Fellowship in Bioinformatics, funding groundbreaking research that has enabled young scientists to make critical discoveries.