John Aitchison is a pioneer in the field of systems biology. He is a founding member of Institute for Systems Biology (ISB), he was the long-time director of the Center for Systems Biology, and now he serves as president and director of Center for Infectious Disease Research (CIDR).
3 Bullets: Dengue virus is the most prevalent mosquito-borne virus worldwide, infecting an estimated 400 million people per year and causing about 25,000 deaths. It’s necessary to understand the molecular mechanisms of dengue replication in order to develop an effective treatment. Researchers at ISB and Seattle BioMed developed a novel approach for identifying host proteins that associate with dengue replication machinery. By Thurston Herricks Dengue virus (DENV) infects approximately 400…
The NIH's National Institute of General Medical Sciences has issued a Biotechnology Resource Grant of $10.9 million over five years to the National Center for Dynamic Interactome Research (ncdir.org) project. This project is a collaboration among The Rockefeller University, Institute for Systems Biology, Seattle BioMed, University of California at San Francisco, New York University and New York Structural Biology Center. Michael Rout, of The Rockefeller University, is the Program Director/Principal…
3 Bullets: ISB researchers are studying peroxisomes, which are cellular organelles that are linked to a rare syndrome that causes progressive organ complications and infant mortality. Peroxisomes have a role in metabolizing and breaking down cellular waste. Because peroxisomes easily change shape and function according to a cell’s needs, a systems approach is necessary to help decipher that complexity. By Dr. Thurston Herricks Dane Tolmie was a 19-month old boy…
Figure depicting cross-disciplinary collaborations among lab groups and usage of technologies housed in ISB’s core facilities. In August, ISB learned that our National Center for Systems Biology was renewed for $13.7 million over the next five years. This is no small feat given that only two National Centers were funded in this round and that there’s fierce competition for diminishing government grants. Here’s how your tax dollars are being put…
