ISB News

Research out of ISB’s Wei Lab reveals how melanoma cells rapidly adapt to targeted therapy through stress-driven changes and NF-κB-mediated chromatin remodeling. The article explores how these early survival mechanisms contribute to drug resistance and highlights potential new therapeutic strategies to improve treatment outcomes.

ISB’s Dr. Wei Wei contributed to research showing that certain lung cancers can shift identity and exist in hybrid states, helping explain treatment resistance and suggesting new approaches to diagnosis and therapy for these aggressive, often underdiagnosed tumors.

Research from ISB’s Gibbons Lab suggests bowel movement frequency is linked to overall health, with a “Goldilocks zone” of about one to two per day. Too few or too many may be associated with risks to kidney, liver, and metabolic health.

A new study finds that a gut bacterium may contribute to memory loss in mice, highlighting growing evidence of connections between the microbiome and brain health. ISB’s Sean Gibbons discusses the study’s implications.

This profile details Lee Hood and his decades-long mission to transform medicine through systems biology and predictive health. Hood outlines how large-scale biological data and longitudinal studies could enable earlier detection of disease and more proactive healthcare.

ISB researchers are using advanced computer simulations of the gut microbiome to explore how probiotics interact with existing microbial communities. The work highlights how modeling approaches can help predict when probiotic strains are likely to thrive — and when they may fail to take hold.