Lab Overview

Hadlock Lab

The Hadlock Lab, led by Dr. Jennifer Hadlock, conducts translational research to improve risk models for clinical decision support and investigates novel methods to accelerate research discovery.

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Infectious Disease Research

Jennifer Hadlock with lab members in a conference room

Dr. Jenn Hadlock with her lab at ISB. Photo credit: Scott Eklund / Red Box Pictures.

Topic: COVID and Long COVID

How Our Immune System Reactions Affect Getting Long-COVID

At least 10 percent of adults with COVID-19 will experience Long COVID with a wide range of health problems extending at least three months after initial infection. The Hadlock Lab, with NIH support, is exploring how our immune system’s adaptive response to COVID-19 infection differs in patients with Long COVID to pinpoint potential prevention and treatment strategies.

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Image credit: NIH All of Us from their sharable resources archive.

Topic: Health Equity

All of Us – More Inclusive Research for Better Treatment

The NIH is leading an effort – All of Us – to correct long-standing disparities in biomedical research resulting in treatments best serving white males. With NIH support, ISB’s Hood and Hadlock labs are analyzing All of Us data from 800,000 enrollees – 80 percent from underrepresented populations – on the effect of genetic variants, which may vary based on sex, race, and ethnicity, on disease risk.

Read Project Summary
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Researcher working at a computer in the mass spec lab at ISB. Photo credit: Steve Utaski / Remedy Pictures.

Topic: Advancing Health

Translating Research to Clinical Care – The First Mile Problem

Accessing the vast multitude of biomedical and scientific data is a bottleneck, slowing the translation of research into care. The Hood Lab’s Gwênlyn Glusman, with the Hadlock and Thorsson-Shmulevich labs, is fixing this “first-mile” problem by integrating data troves into the Biomedical Data Translator. The Translator enables researchers to access and query this knowledge, extracting information urgently needed to improve clinical care.

Latest Hadlock Lab News

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Dr. Jennifer Hadlock and Dr. Alexandra Ralevski

ISB Study Highlights AI’s Potential and Pitfalls in Analyzing Health Data

New research highlights strengths of large language models in uncovering social determinants of health while underscoring the need for human oversight and improved de-identification methods.

ISB Study Highlights AI’s Potential and Pitfalls in Analyzing Health Data
ISB Study Highlights AI’s Potential and Pitfalls in Analyzing Health Data
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Timing is Everything: ISB Study Finds Link Between Bowel Movement Frequency and Overall Health

Everybody poops, but not every day. An ISB-led research team examined the clinical, lifestyle, and multi-omic data of more than 1,400 healthy adults. How often people poop, they found, can have a large influence on one’s physiology and health.

Timing is Everything: ISB Study Finds Link Between Bowel Movement Frequency and Overall Health
Timing is Everything: ISB Study Finds Link Between Bowel Movement Frequency and Overall Health
screenshot of video for Autoimmune Disease and Pregnancy: ISB Study Challenges Prevailing Wisdom, Unveils Nuances

Autoimmune Disease and Pregnancy: ISB Study Challenges Prevailing Wisdom, Unveils Nuances

An ISB-led study showed nuanced pregnancy outcomes for pregnant individuals with autoimmune disease. The findings reinforce that there isn’t a one-size-fits-all approach, and provides important new avenues for further investigation.

Autoimmune Disease and Pregnancy: ISB Study Challenges Prevailing Wisdom, Unveils Nuances
Autoimmune Disease and Pregnancy: ISB Study Challenges Prevailing Wisdom, Unveils Nuances
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Jennifer Hadlock

Contact Dr. Jennifer Hadlock

Associate Professor and Director of Medical Data Science

ISB