New peer-reviewed research out of ISB highlights the strengths of large language models in uncovering social determinants of health while underscoring the need for human oversight and improved de-identification methods.
ISB Assistant Professor Dr. Sid Venkatesh is the co-first author of a paper in the journal Science. While at Washington University in St. Louis, Venkatesh and colleagues identified a novel gut microbial enzyme that impacts satiety-related signaling pathways in undernourished children treated with microbiota-directed complementary foods.
Faduma Hussein recently joined the ISB Education team as the Public Health Ambassador Coordinator, becoming only the fourth AmeriCorps member to serve at ISB. In this Q&A, she shares insights into her education, what drew her to ISB, career aspirations, and more.
In the first installment of the 2024-25 academic year roundup, we highlight some of the top projects the ISB Education team is working on. In October, we welcomed new team members, developed a new format for our popular “Systems Are Everywhere!” workshop, and more.
Our multi-day microbiome-themed virtual course and symposium is back for the fifth year! ISB is hosting a two-day course on October 16 & 17, 2024, followed by a symposium on October 18, 2024 titled, “A gut feeling: Microbes and their impacts on our minds.” Both events are virtual and free.
ISB researchers examined representative organisms of two classes of microbes whose interaction contributes to the conversion of more than 1 gigaton of carbon into methane every year. They found that gene mutations selected over a relatively short timeframe in the two microbes led to distinct functions.
Everybody poops, but not every day. An ISB-led research team examined the clinical, lifestyle, and multi-omic data of more than 1,400 healthy adults. How often people poop, they found, can have a large influence on one’s physiology and health.
Wei Wei, PhD – an accomplished cancer researcher with expertise in biotechnology and cancer systems biology – has been promoted to ISB associate professor. The Wei Lab focuses on understanding how cancer cells adapt to therapeutic treatment to foster therapy resistance by coordinating their internal molecular machinery and how these adaptive changes evolve within diverse tumors influenced by the tumor microenvironment.
Glioblastoma is one of the deadliest and most aggressive forms of primary brain cancer in adults and is known for its ability to resist treatment and to recur. ISB researchers have made breakthrough discoveries in understanding the mechanisms behind acquired resistance, focusing on a rare and stubborn group of cells within tumors called glioma stem-like cells.
Netflix’s “Hack Your Health: The Secrets of Your Gut” is a documentary that merged gut microbiome experts, four individuals – including a well-known hot dog eating champion – facing personal battles with gastrointestinal health, and a unique, effective visual method of “showing” the gut microbiome in action.
ISB researchers have developed a novel way to simulate personalized, microbiome-mediated responses to diet. They use a microbial community-scale metabolic modeling (MCMM) approach to predict individual-specific short-chain fatty acid production rates in response to different dietary, prebiotic, and probiotic inputs.
In the final installment of the 2023-24 academic year roundup, we highlight some of the top projects the ISB Education team is working on. Throughout the summer, the ISB Education was busy publishing research in a special edition of Connected Science Learning, hosting interns, and much more.
Devoted husband and father. Animal lover. Accomplished pianist. Avid cyclist. Compassionate human. Exceptional scientist. The ISB community mourns the loss of Professor Ilya Shmulevich, PhD, who died on April 13, 2024. He was 54 years old.
Dr. Sean Gibbons is creating a new precision nutrition platform called My Digital Gut that leverages the gut microbiome to make nutrition and healthcare personalized, predictive, and preventive. In an ISB Research Roundtable presentation, Gibbons spoke about My Digital Gut and other microbiome-related projects studied in his lab.
A new study unveils important insights and actionable protocols into providing equitable STEM experiences for high school students from historically marginalized communities. The research highlights the transformative power of informal STEM learning and the ease with which many organizations could provide these opportunities.
Infection, autoimmunity and cancer account for 40 percent of deaths worldwide. In a Cell Reports paper, ISB researchers detail how the human immune system works in common ways across diseases – findings that offer promising avenues for exploring multi-disease therapeutic strategies.
In a breakthrough discovery that changes how we understand T cells and with implications of how we can better engineer custom immune responses to fight disease, Institute for Systems Biology researchers showed that the different disease-fighting functions of different T cells are determined by the genetically encoded T-cell receptor sequence that are unique to those cells.
An ISB-led study showed nuanced pregnancy outcomes for pregnant individuals with autoimmune disease. The findings reinforce that there isn’t a one-size-fits-all approach, and provides important new avenues for further investigation.
