Wei Wei, PhD

Andy Hill CARE Distinguished Researcher & Assistant Professor

Wei Wei

Dr. Wei Wei is an Assistant Professor at the Institute for Systems Biology. He also has the positions of Affiliated Assistant Professor at the UCLA Department of Molecular and Medical Pharmacology and member of the Jonsson Comprehensive Cancer Center. He received his B.S. in Fundamental Sciences (Mathematics and Physics) at Tsinghua University (Beijing) and M.S. in Materials Sciences and Engineering at UC San Diego. He obtained his Ph.D. at California Institute of Technology in 2014 with cross-disciplinary training that included both physical and biological sciences. Before joining ISB, Wei was an Assistant Professor at UCLA until mid-2018.

Wei received the Chinese Government Award for Outstanding Student Abroad in 2013. In 2014, he was the sole recipient of the Milton and Francis Clauser Doctoral Prize – the highest honor for a Caltech Ph.D. He received the Andy Hill Cancer Research Endowment Distinguished Researchers award in 2019. Currently, he is the co-director of the NCI-funded ISB/UCLA Physical Sciences in Oncology Program (PS-OP), and a Project Lead in NCI-funded NSB Cancer Center.

Wei’s research interests reside in a highly cross-disciplinary field of BioMEMS, molecular and cellular analysis, and systems biomedicine. Wei’s group is developing and deploying a unique suite of single-cell tools and computational approaches to cultivate new understanding in cancer systems biology and address significant questions in translational cancer research.

Single-cell analysis, BioMEMS, cancer molecular diagnosis, cancer epigenetic plasticity, multivariate data analysis

2014           Ph.D. in Materials Sciences, California Institute of Technology

2008           M.S. in Materials Sciences and Engineering, UC San Diego

2005           B.S. in Fundamental Sciences (Mathematics and Physics), Tsinghua University

Wei, Wei, Kaili Jiang, Yang Wei, Ming Liu, Haitao Yang, Lina Zhang, Qunqing Li, Liang Liu, and Shoushan Fan. 2006. “Measuring the Stress in Field-Emitting Carbon Nanotubes.” Nanotechnology 17 (8): 1994. https://doi.org/10.1088/0957-4484/17/8/033. Cite
Wei, Wei, Kaili Jiang, Yang Wei, Peng Liu, Kai Liu, Lina Zhang, Qunqing Li, and Shoushan Fan. 2006. “LaB6 Tip-Modified Multiwalled Carbon Nanotube as High Quality Field Emission Electron Source.” Applied Physics Letters 89 (20): 203112. https://doi.org/10.1063/1.2388862. Cite
Wei, Wei, Yang Liu, Yang Wei, Kaili Jiang, Lian-Mao Peng, and Shoushan Fan. 2006. “Tip Cooling Effect and Failure Mechanism of Field-Emitting Carbon Nanotubes.” Nano Letters 7 (1): 64–68. https://doi.org/10.1021/nl061982u. Cite
Bao, Xin-Yu, Cesare Soci, Darija Susac, Jon Bratvold, David P. R. Aplin, Wei Wei, Ching-Yang Chen, Shadi A. Dayeh, Karen L. Kavanagh, and Deli Wang. 2008. “Heteroepitaxial Growth of Vertical GaAs Nanowires on Si (111) Substrates by Metal−Organic Chemical Vapor Deposition.” Nano Letters 8 (11): 3755–60. https://doi.org/10.1021/nl802062y. Cite
Wei, Yang, Wei Wei, Liang Liu, and Shoushan Fan. 2008. “Mounting Multi-Walled Carbon Nanotubes on Probes by Dielectrophoresis.” Diamond and Related Materials 17 (11): 1877–80. https://doi.org/10.1016/j.diamond.2008.04.001. Cite
Wei, Wei, Xin-Yu Bao, Cesare Soci, Yong Ding, Zhong-Lin Wang, and Deli Wang. 2009. “Direct Heteroepitaxy of Vertical InAs Nanowires on Si Substrates for Broad Band Photovoltaics and Photodetection.” Nano Letters 9 (8): 2926–34. https://doi.org/10.1021/nl901270n. Cite
Shin, Young Shik, F. Remacle, Rong Fan, Kiwook Hwang, Wei Wei, Habib Ahmad, R. D. Levine, and James R. Heath. 2011. “Protein Signaling Networks from Single Cell Fluctuations and Information Theory Profiling.” Biophysical Journal 100 (10): 2378–86. https://doi.org/10.1016/j.bpj.2011.04.025. Cite
Sun, Ke, Wei Wei, Yong Ding, Yi Jing, Zhong Lin Wang, and Deli Wang. 2011. “Crystalline ZnO Thin Film by Hydrothermal Growth.” Chemical Communications 47 (27): 7776–78. https://doi.org/10.1039/C1CC11397F. Cite
Yang, Tingbin, Ke Sun, Xilan Liu, Wei Wei, Tianzhi Yu, Xiong Gong, Deli Wang, and Yong Cao. 2012. “Zinc Oxide Nanowire As an Electron-Extraction Layer for Broadband Polymer Photodetectors with an Inverted Device Structure.” The Journal of Physical Chemistry C 116 (25): 13650–53. https://doi.org/10.1021/jp303016f. Cite
Shi, Qihui, Lidong Qin, Wei Wei, Feng Geng, Rong Fan, Young Shik Shin, Deliang Guo, Leroy Hood, Paul S. Mischel, and James R. Heath. 2012. “Single-Cell Proteomic Chip for Profiling Intracellular Signaling Pathways in Single Tumor Cells.” Proceedings of the National Academy of Sciences 109 (2): 419–24. https://doi.org/10.1073/pnas.1110865109. Cite
Wang, Jun, Douglas Tham, Wei Wei, Young Shik Shin, Chao Ma, Habib Ahmad, Qihui Shi, Jenkan Yu, Raphael D. Levine, and James R. Heath. 2012. “Quantitating Cell–Cell Interaction Functions with Applications to Glioblastoma Multiforme Cancer Cells.” Nano Letters 12 (12): 6101–6. https://doi.org/10.1021/nl302748q. Cite
Wei, Wei, Young Shik Shin, Chao Ma, Jun Wang, Meltem Elitas, Rong Fan, and James R. Heath. 2013. “Microchip Platforms for Multiplex Single-Cell Functional Proteomics with Applications to Immunology and Cancer Research.” Genome Medicine 5 (8): 75. https://doi.org/10.1186/gm479. Cite
Wei, Wei, Qihui Shi, Francoise Remacle, Lidong Qin, David B. Shackelford, Young Shik Shin, Paul S. Mischel, R. D. Levine, and James R. Heath. 2013. “Hypoxia Induces a Phase Transition within a Kinase Signaling Network in Cancer Cells.” Proceedings of the National Academy of Sciences of the United States of America 110 (15): E1352-1360. https://doi.org/10.1073/pnas.1303060110. Cite
Yu, Jing, Jing Zhou, Alex Sutherland, Wei Wei, Young Shik Shin, Min Xue, and James R. Heath. 2014. “Microfluidics-Based Single-Cell Functional Proteomics for Fundamental and Applied Biomedical Applications.” Annual Review of Analytical Chemistry (Palo Alto, Calif.) 7: 275–95. https://doi.org/10.1146/annurev-anchem-071213-020323. Cite
Jing, Yi, Xinyu Bao, Wei Wei, Chun Li, Ke Sun, David P. R. Aplin, Yong Ding, Zhong-Lin Wang, Yoshio Bando, and Deli Wang. 2014. “Catalyst-Free Heteroepitaxial MOCVD Growth of InAs Nanowires on Si Substrates.” The Journal of Physical Chemistry C 118 (3): 1696–1705. https://doi.org/10.1021/jp406428z. Cite
Yu, Jing, Jing Zhou, Alex Sutherland, Wei Wei, Young Shik Shin, Min Xue, and James R. Heath. 2014. “Microfluidics-Based Single-Cell Functional Proteomics for Fundamental and Applied Biomedical Applications.” Annual Review of Analytical Chemistry 7 (1): 275–95. https://doi.org/10.1146/annurev-anchem-071213-020323. Cite
Deng, Yuliang, Yu Zhang, Shuai Sun, Zhihua Wang, Minjiao Wang, Beiqin Yu, Daniel M. Czajkowsky, et al. 2014. “An Integrated Microfluidic Chip System for Single-Cell Secretion Profiling of Rare Circulating Tumor Cells.” Scientific Reports 4: 7499. https://doi.org/10.1038/srep07499. Cite
Xue, Min, Wei Wei, Yapeng Su, Jungwoo Kim, Young Shik Shin, Wilson X. Mai, David A. Nathanson, and James R. Heath. 2015. “Chemical Methods for the Simultaneous Quantitation of Metabolites and Proteins from Single Cells.” Journal of the American Chemical Society 137 (12): 4066–69. https://doi.org/10.1021/jacs.5b00944. Cite
Zhang, Yu, Yin Tang, Shuai Sun, Zhihua Wang, Wenjun Wu, Xiaodong Zhao, Daniel M. Czajkowsky, et al. 2015. “Single-Cell Codetection of Metabolic Activity, Intracellular Functional Proteins, and Genetic Mutations from Rare Circulating Tumor Cells.” Analytical Chemistry 87 (19): 9761–68. https://doi.org/10.1021/acs.analchem.5b01901. Cite
Wei, Wei, Young Shik Shin, Min Xue, Tomoo Matsutani, Kenta Masui, Huijun Yang, Shiro Ikegami, et al. 2016. “Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma.” Cancer Cell 29 (4): 563–73. https://doi.org/10.1016/j.ccell.2016.03.012. Cite
Yang, Liu, Zhihua Wang, Yuliang Deng, Yan Li, Wei Wei, and Qihui Shi. 2016. “Single-Cell, Multiplexed Protein Detection of Rare Tumor Cells Based on a Beads-on-Barcode Antibody Microarray.” Analytical Chemistry 88 (22): 11077–83. https://doi.org/10.1021/acs.analchem.6b03086. Cite
Xue, Min, Wei Wei, Yapeng Su, Dazy Johnson, and James R. Heath. 2016. “Supramolecular Probes for Assessing Glutamine Uptake Enable Semi-Quantitative Metabolic Models in Single Cells.” Journal of the American Chemical Society 138 (9): 3085–93. https://doi.org/10.1021/jacs.5b12187. Cite
Tang, Yin, Zhuo Wang, Ziming Li, Jungwoo Kim, Yuliang Deng, Yan Li, James R. Heath, Wei Wei, Shun Lu, and Qihui Shi. 2017. “High-Throughput Screening of Rare Metabolically Active Tumor Cells in Pleural Effusion and Peripheral Blood of Lung Cancer Patients.” Proceedings of the National Academy of Sciences of the United States of America 114 (10): 2544–49. https://doi.org/10.1073/pnas.1612229114. Cite
Su, Yapeng, Qihui Shi, and Wei Wei. 2017. “Single Cell Proteomics in Biomedicine: High-Dimensional Data Acquisition, Visualization, and Analysis.” Proteomics 17 (3–4). https://doi.org/10.1002/pmic.201600267. Cite
Su, Yapeng, Wei Wei, Lidia Robert, Min Xue, Jennifer Tsoi, Angel Garcia-Diaz, Blanca Homet Moreno, et al. 2017. “Single-Cell Analysis Resolves the Cell State Transition and Signaling Dynamics Associated with Melanoma Drug-Induced Resistance.” Proceedings of the National Academy of Sciences of the United States of America 114 (52): 13679–84. https://doi.org/10.1073/pnas.1712064115. Cite
Lu, Yao, Liu Yang, Wei Wei, and Qihui Shi. 2017. “Microchip-Based Single-Cell Functional Proteomics for Biomedical Applications.” Lab on a Chip 17 (7): 1250–63. https://doi.org/10.1039/c7lc00037e. Cite
Li, Zhonghan, Hanjun Cheng, Shiqun Shao, Xiang Lu, Li Mo, Jonathan Tsang, Pu Zeng, et al. 2018. “Surface Immobilization of Redox-Labile Fluorescent Probes: Enabling Single-Cell Co-Profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities.” Angewandte Chemie (International Ed. in English). https://doi.org/10.1002/anie.201803034. Cite
Shao, Shiqun, Zhonghan Li, Hanjun Cheng, Siwen Wang, Nicole G. Perkins, Priyanka Sarkar, Wei Wei, and Min Xue. 2018. “A Chemical Approach for Profiling Intracellular AKT Signaling Dynamics from Single Cells.” Journal of the American Chemical Society. https://doi.org/10.1021/jacs.8b08931. Cite
Wen, Patrick Y., Mehdi Touat, Brian M. Alexander, Ingo K. Mellinghoff, Shakti Ramkissoon, Christine S. McCluskey, Kristine Pelton, et al. 2019. “Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.” Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, JCO1801207. https://doi.org/10.1200/JCO.18.01207. Cite
Su, Yapeng, Marcus Bintz, Yezi Yang, Lidia Robert, Alphonsus H. C. Ng, Victoria Liu, Antoni Ribas, James R. Heath, and Wei Wei. 2019. “Phenotypic Heterogeneity and Evolution of Melanoma Cells Associated with Targeted Therapy Resistance.” PLoS Computational Biology 15 (6): e1007034. https://doi.org/10.1371/journal.pcbi.1007034. Cite
Li, Ziming, Zhuo Wang, Yin Tang, Xiang Lu, Jie Chen, Yu Dong, Baojun Wu, et al. 2019. “Liquid Biopsy-Based Single-Cell Metabolic Phenotyping of Lung Cancer Patients for Informative Diagnostics.” Nature Communications 10 (1): 3856. https://doi.org/10.1038/s41467-019-11808-3. Cite
Wei, Wei, and Rong Fan. 2019. “Special Issue on Single-Cell Multi-Omics for Immuno-Oncology and Cancer Systems Biology.” Proteomics, e1900235. https://doi.org/10.1002/pmic.201900235. Cite
Su, Yapeng, Guideng Li, Melissa E. Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica Wang, et al. 2019. “Trajectories from Snapshots: Integrated Proteomic and Metabolic Single-Cell Assays Reveal Multiple Independent Adaptive Responses to Drug Tolerance in a BRAF-Mutant Melanoma Cell Line.” BioRxiv, 767988. https://doi.org/10.1101/767988. Cite

Wei Lab
Institute for Systems Biology
401 Terry Ave N
Seattle WA 98109

Email: wwei@isbscience.org