Wei Wei, PhD

Andy Hill CARE Distinguished Researcher & Assistant Professor

Wei Wei

Dr. Wei Wei is an Assistant Professor at the Institute for Systems Biology. He also has the positions of Affiliated Assistant Professor at the UCLA Department of Molecular and Medical Pharmacology and member of the Jonsson Comprehensive Cancer Center. He received his B.S. in Fundamental Sciences (Mathematics and Physics) at Tsinghua University (Beijing) and M.S. in Materials Sciences and Engineering at UC San Diego. He obtained his Ph.D. at California Institute of Technology in 2014 with cross-disciplinary training that included both physical and biological sciences. Before joining ISB, Wei was an Assistant Professor at UCLA until mid-2018.

Wei received the Chinese Government Award for Outstanding Student Abroad in 2013. In 2014, he was the sole recipient of the Milton and Francis Clauser Doctoral Prize – the highest honor for a Caltech Ph.D. He received the Andy Hill Cancer Research Endowment Distinguished Researchers award in 2019. Currently, he is the co-director of the NCI-funded ISB/UCLA Physical Sciences in Oncology Program (PS-OP), and a Project Lead in NCI-funded NSB Cancer Center.

Wei’s research interests reside in a highly cross-disciplinary field of BioMEMS, molecular and cellular analysis, and systems biomedicine. Wei’s group is developing and deploying a unique suite of single-cell tools and computational approaches to cultivate new understanding in cancer systems biology and address significant questions in translational cancer research.

Single-cell analysis, BioMEMS, cancer molecular diagnosis, cancer epigenetic plasticity, multivariate data analysis

2014           Ph.D. in Materials Sciences, California Institute of Technology

2008           M.S. in Materials Sciences and Engineering, UC San Diego

2005           B.S. in Fundamental Sciences (Mathematics and Physics), Tsinghua University

Su, Yapeng, Dan Yuan, Daniel G. Chen, Kai Wang, Jongchan Choi, Chengzhen L. Dai, Sunga Hong, et al. 2021. “Heterogeneous Immunological Recovery Trajectories Revealed in Post-Acute COVID-19.” MedRxiv, 2021.03.19.21254004. https://doi.org/10.1101/2021.03.19.21254004. Cite
Cheng, Hanjun, Zhonghan Li, Zhili Guo, Shiqun Shao, Li Mo, Wei Wei, and Min Xue. 2021. “Single-Cell Profiling of D-2-Hydroxyglutarate Using Surface-Immobilized Resazurin Analogs.” Biosensors and Bioelectronics, 113368. https://doi.org/10.1016/j.bios.2021.113368. Cite
Yang, Liu, Xiaowei Yan, Jie Chen, Qiong Zhan, Yingqi Hua, Shili Xu, Ziming Li, et al. 2021. “Hexokinase 2 Discerns a Novel Circulating Tumor Cell Population Associated with Poor Prognosis in Lung Cancer Patients.” Proceedings of the National Academy of Sciences of the United States of America 118 (11). https://doi.org/10.1073/pnas.2012228118. Cite
Su, Yapeng, Guideng Li, Melissa Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Lidia Robert, et al. 2020. “Abstract 6585: Systems Biology for Investigating Drug Resistance Mechanism of Melanoma.” Cancer Research 80 (16 Supplement): 6585–6585. https://doi.org/10.1158/1538-7445.AM2020-6585. Cite
Wang, Zhuo, Jie Chen, Liu Yang, Mingzhe Cao, Yanlan Yu, Rulin Zhang, Heng Quan, et al. 2020. “Single-Cell Sequencing-Enabled Hexokinase 2 Assay for Noninvasive Bladder Cancer Diagnosis and Screening by Detecting Rare Malignant Cells in Urine.” Analytical Chemistry 92 (24): 16284–92. https://doi.org/10.1021/acs.analchem.0c04282. Cite
Cheng, Hanjun, Rong Fan, and Wei Wei. 2020. “Cancer Systems Biology in the Era of Single-Cell Multi-Omics.” Proteomics 20 (13): e1900106. https://doi.org/10.1002/pmic.201900106. Cite
Su, Yapeng, Daniel Chen, Dan Yuan, Christopher Lausted, Jongchan Choi, Chengzhen L. Dai, Valentin Voillet, et al. 2020. “Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.” Cell, S0092867420314446. https://doi.org/10.1016/j.cell.2020.10.037. Cite
Su, Yapeng, Melissa E. Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica Wang, Jihoon W. Lee, et al. 2020. “Multi-Omic Single-Cell Snapshots Reveal Multiple Independent Trajectories to Drug Tolerance in a Melanoma Cell Line.” Nature Communications 11 (1): 2345. https://doi.org/10.1038/s41467-020-15956-9. Cite
Yang, Liu, Xiaowei Yan, Jie Chen, Qiong Zhan, Yingqi Hua, Shili Xu, Yu Dong, et al. 2020. “Resolving an Underrepresented Circulating Tumor Cell Population in Lung Cancer Enabled by Hexokinase 2 Analysis.” BioRxiv, 2020.04.27.064345. https://doi.org/10.1101/2020.04.27.064345. Cite
Su, Yapeng, Guideng Li, Melissa E. Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica Wang, et al. 2019. “Trajectories from Snapshots: Integrated Proteomic and Metabolic Single-Cell Assays Reveal Multiple Independent Adaptive Responses to Drug Tolerance in a BRAF-Mutant Melanoma Cell Line.” BioRxiv, 767988. https://doi.org/10.1101/767988. Cite
Wei, Wei, and Rong Fan. 2019. “Special Issue on Single-Cell Multi-Omics for Immuno-Oncology and Cancer Systems Biology.” Proteomics, e1900235. https://doi.org/10.1002/pmic.201900235. Cite
Li, Ziming, Zhuo Wang, Yin Tang, Xiang Lu, Jie Chen, Yu Dong, Baojun Wu, et al. 2019. “Liquid Biopsy-Based Single-Cell Metabolic Phenotyping of Lung Cancer Patients for Informative Diagnostics.” Nature Communications 10 (1): 3856. https://doi.org/10.1038/s41467-019-11808-3. Cite
Su, Yapeng, Marcus Bintz, Yezi Yang, Lidia Robert, Alphonsus H. C. Ng, Victoria Liu, Antoni Ribas, James R. Heath, and Wei Wei. 2019. “Phenotypic Heterogeneity and Evolution of Melanoma Cells Associated with Targeted Therapy Resistance.” PLoS Computational Biology 15 (6): e1007034. https://doi.org/10.1371/journal.pcbi.1007034. Cite
Wen, Patrick Y., Mehdi Touat, Brian M. Alexander, Ingo K. Mellinghoff, Shakti Ramkissoon, Christine S. McCluskey, Kristine Pelton, et al. 2019. “Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.” Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, JCO1801207. https://doi.org/10.1200/JCO.18.01207. Cite

Wei Lab
Institute for Systems Biology
401 Terry Ave N
Seattle WA 98109

Email: wwei@isbscience.org