Dr. Arrieta-Ortiz builds genome-wide models to uncover regulatory and metabolic programs that coordinate physiological changes that allow bacteria to thrive in the host environment and survive antibiotic-induced stress. His goal is to identify pathogen vulnerabilities to inform the design of new antimicrobial therapies.

During his PhD at New York University, Dr. Arrieta-Ortiz developed and applied computational tools to construct accurate and informative gene regulatory network models that integrate transcriptional and post-transcriptional regulation. At ISB, Dr. Arrieta-Ortiz is developing conceptual and systems biology frameworks to dissect microbial adaptive strategies. Dr. Arrieta-Ortiz has applied these integrative frameworks to characterize in vivo virulence and adaptive responses of multiple bacterial pathogens, including Clostridioides difficile and Mycobacterium tuberculosis.