isbscience.org/bio/kathie-walters-phd/Dr. Walters’s research interests include: i) underlying pathological processes associated with pandemic respiratory viruses including 1918 and 2009 influenza viruses and the SARS-CoV-2/COVID-19 coronavirus, ii) host-pathogen interactions and how it relates to disease susceptibility, progression and/or recovery, and iii) using multi-omics data to identify novel therapeutic targets and diagnostic/prognostic biomarkers of infection. Currently, Dr. Walters is applying systems-based approaches to a human challenge model of influenza virus to both identify prognostic markers of viral shedding, disease severity and correlates of immune protection with the goal of improving the performance of current vaccines. She is also interested in exploring the underlying mechanisms of secondary bacterial infection as a major cause of morbidity/mortality during influenza virus infection, particularly with pandemic-causing strains including the 1918 H1N1 influenza virus which was responsible for 50 million deaths worldwide.
Virology, host-pathogen interactions, systems biology approaches to infectious disease, biomarkers
Ph.D., Virology, University of Alberta, 2003
B. Sc., Biological sciences, University of Alberta, 1995
Regulatory Affairs Certificate, Pharmaceuticals, Regulatory Affairs Professional Society, 2014
Walters, K.A. 2021. “Lung Epithelial and Endothelial Damage, Loss of Tissue Repair, Inhibition of Fibrinolysis, and Cellular Senescence in Fatal COVID-19.” 2021. https://www.science.org/doi/10.1126/scitranslmed.abj7790. Cite
Giurgea, Luca T., Adriana Cervantes-Medina, K.A. Walters, Kelsey Scherler, Alison Han, Lindsay M. Czajkowski, Holly Ann Baus, et al. 2021. “Sex Differences in Influenza: The Challenge Study Experience.” The Journal of Infectious Diseases, jiab422. https://doi.org/10.1093/infdis/jiab422. Cite Download
Giurgea, Luca T., Jae-Keun Park, K.A. Walters, Kelsey Scherler, Adriana Cervantes-Medina, Ashley Freeman, Luz Angela Rosas, John C. Kash, Jeffery K. Taubenberger, and Matthew J. Memoli. 2021. “The Effect of Calcium and Magnesium on Activity, Immunogenicity, and Efficacy of a Recombinant N1/N2 Neuraminidase Vaccine.” NPJ Vaccines 6 (1): 48. https://doi.org/10.1038/s41541-021-00310-x. Cite Download
Park, Jae-Keun, Yongli Xiao, Mitchell D. Ramuta, Luz Angela Rosas, Sharon Fong, Alexis M. Matthews, Ashley D. Freeman, et al. 2020. “Pre-Existing Immunity to Influenza Virus Hemagglutinin Stalk Might Drive Selection for Antibody-Escape Mutant Viruses in a Human Challenge Model.” Nature Medicine 26 (8): 1240–46. https://doi.org/10.1038/s41591-020-0937-x. Cite Download
Walters, K.A., Ruoqing Zhu, Michael Welge, Kelsey Scherler, Jae-Keun Park, Zainab Rahil, Hao Wang, et al. 2019. “Differential Effects of Influenza Virus NA, HA Head, and HA Stalk Antibodies on Peripheral Blood Leukocyte Gene Expression during Human Infection.” MBio 10 (3). https://doi.org/10.1128/mBio.00760-19. Cite Download
Lee, Min Young, Taek-Kyun Kim, K.A. Walters, and Kai Wang. 2019. “A Biological Function Based Biomarker Panel Optimization Process.” Scientific Reports 9 (1): 7365. https://doi.org/10.1038/s41598-019-43779-2. Cite Download
Memoli, Matthew J., Alison Han, K.A. Walters, Lindsay Czajkowski, Susan Reed, Rani Athota, Luz Angela Rosas, et al. 2019. “Influenza A Reinfection in Sequential Human Challenge: Implications for Protective Immunity and ‘Universal’ Vaccine Development.” Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. https://doi.org/10.1093/cid/ciz281. Cite
Kash, John C., K.A. Walters, Jason Kindrachuk, David Baxter, Kelsey Scherler, Krisztina B. Janosko, Rick D. Adams, et al. 2017. “Longitudinal Peripheral Blood Transcriptional Analysis of a Patient with Severe Ebola Virus Disease.” Science Translational Medicine 9 (385). https://doi.org/10.1126/scitranslmed.aai9321. Cite
Walters, K.A., F. D’Agnillo, Z. M. Sheng, J. Kindrachuk, L. M. Schwartzman, R. E. Kuestner, D. S. Chertow, B. T. Golding, J. K. Taubenberger, and J. C. Kash. 2016. “1918 Pandemic Influenza Virus and Streptococcus Pneumoniae Co-Infection Results in Activation of Coagulation and Widespread Pulmonary Thrombosis in Mice and Humans.” The Journal of Pathology 238: 85–97. https://doi.org/10.1002/path.4638. Cite
Walters, K.A., R. Olsufka, R. E. Kuestner, X. Wu, K. Wang, S. J. Skerrett, and A. Ozinsky. 2015. “Prior Infection with Type A Francisella Tularensis Antagonizes the Pulmonary Transcriptional Response to an Aerosolized Toll-like Receptor 4 Agonist.” BMC Genomics 16: 874. https://doi.org/10.1186/s12864-015-2022-2. Cite
Grosse-Wilde, Anne, Aymeric Fouquier d’Hérouël, Ellie McIntosh, Gökhan Ertaylan, Alexander Skupin, Rolf E. Kuestner, Antonio Del Sol, K.A. Walters, and S. Huang. 2015. “Stemness of the Hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival.” PLoS One 10: e0126522. https://doi.org/10.1371/journal.pone.0126522. Cite
Kash, J. C., Y. Xiao, A. S. Davis, K.A. Walters, D. S. Chertow, J. D. Easterbrook, R. L. Dunfee, et al. 2014. “Treatment with the Reactive Oxygen Species Scavenger EUK-207 Reduces Lung Damage and Increases Survival during 1918 Influenza Virus Infection in Mice.” Free Radical Biology & Medicine 67 (February): 235–47. Cite
Qi, Li, Lindsey M. Pujanauski, A. Sally Davis, Louis M. Schwartzman, Daniel S. Chertow, David Baxter, Kelsey Scherler, et al. 2014. “Contemporary Avian Influenza A Virus Subtype H1, H6, H7, H10, and H15 Hemagglutinin Genes Encode a Mammalian Virulence Factor Similar to the 1918 Pandemic Virus H1 Hemagglutinin.” MBio 5 (6): e02116. https://doi.org/10.1128/mBio.02116-14. Cite
Walters, K.A., R. Olsufka, R. E. Kuestner, J. H. Cho, H. Li, G. A. Zornetzer, K. Wang, S. J. Skerrett, and A. Ozinsky. 2013. “Francisella Tularensis Subsp. Tularensis Induces a Unique Pulmonary Inflammatory Response: Role of Bacterial Gene Expression in Temporal Regulation of Host Defense Responses.” PLoS One 8 (5): e62412. Cite
Rasmussen, Angela L., Nicolas Tchitchek, Nathan J. Susnow, Alexei L. Krasnoselsky, Deborah L. Diamond, Matthew M. Yeh, Sean C. Proll, et al. 2012. “Early Transcriptional Programming Links Progression to Hepatitis C Virus-Induced Severe Liver Disease in Transplant Patients.” Hepatology 56 (July): 17–27. https://doi.org/10.1002/hep.25612. Cite
Diamond, Deborah L., Alexei L. Krasnoselsky, Kristin E. Burnum, Matthew E. Monroe, Bobbie-Jo Webb-Robertson, Jason E. McDermott, Matthew M. Yeh, et al. 2012. “Proteome and Computational Analyses Reveal New Insights into the Mechanisms of Hepatitis C Virus-Mediated Liver Disease Posttransplantation.” Hepatology 56 (July): 28–38. https://doi.org/10.1002/hep.25649. Cite
Jagger, B. W., H. M. Wise, J. C. Kash, K.A. Walters, N. M. Wills, Y. L. Xiao, R. L. Dunfee, et al. 2012. “An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response.” Science, June. Cite
Kash, John C., K.A. Walters, A. Sally Davis, Aline Sandouk, Louis M. Schwartzman, Brett W. Jagger, Daniel S. Chertow, et al. 2011. “Lethal Synergism of 2009 Pandemic H1N1 Influenza Virus and Streptococcus Pneumoniae Coinfection Is Associated with Loss of Murine Lung Repair Responses.” MBio 2 (5). https://doi.org/10.1128/mBio.00172-11. Cite