Jennifer Hadlock, MD

Associate Professor and Director of Medical Data Science

Jennifer Hadlock

Dr. Hadlock’s research aim is to understand transitions between wellness and disease, and accelerate translational research by integrating clinical data into systems biology at scale. Her long-term vision is to improve the lives of people with immune-mediated inflammatory diseases (IMIDs), which include ulcerative colitis, Crohn’s disease, rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, Sjögren’s syndrome and others, including numerous rare diseases.

The Hadlock Lab focuses on developing models from high-fidelity, longitudinal observations of multiomics, phenotype, exposures and patient-centered outcomes. Current areas of research include IMIDs, immunomodulatory medications, chronic multimorbidities and maternal/fetal health, as well as improving machine learning methods and knowledge graphs for supporting translational systems medicine.

She received her MD at the University of Washington School of Medicine in 2015, including training in the Rural/Urban Underserved Pathway. Prior to that, she was a Principal Software Engineer in research and development at Microsoft, analyzing and optimizing end-user quality for natural language processing, geographic information systems and real-time digital imaging. She successfully led numerous teams working on technologies that have been used by hundreds of millions of people worldwide.

Medical informatics, machine learning, immune-mediated inflammatory disease, maternal/fetal health

2015
MD, University of Washington School of Medicine

2003
BS Computing and Software Systems, University of Washington

1990
BS Mathematics, Geographic Information Systems, University of Oregon

Hwang, Yeon Mi, Ryan T. Roper, Samantha N. Piekos, Daniel A. Enquobahrie, Mary F. Hebert, Alison G. Paquette, Priyanka Baloni, Nathan D. Price, Leroy Hood, and Jennifer J. Hadlock. 2024. “Timing of Selective Serotonin Reuptake Inhibitor Use and Risk for Preterm Birth and Related Adverse Events: With a Consideration of the COVID-19 Pandemic Period.” The Journal of Maternal-Fetal & Neonatal Medicine 37 (1): 2313364. https://doi.org/10.1080/14767058.2024.2313364. Cite Download
Hwang, Yeon Mi, Qi Wei, Samantha N. Piekos, Bhargav Vemuri, Sevda Molani, Philip Mease, Leroy Hood, and Jennifer Hadlock. 2024. “Maternal-Fetal Outcomes in Patients with Immune-Mediated Inflammatory Diseases, with Consideration of Comorbidities: A Retrospective Cohort Study in a Large U.S. Healthcare System.” EClinicalMedicine 0 (0). https://doi.org/10.1016/j.eclinm.2024.102435. Cite Download
Baumgartner, Andrew, Max Robinson, Sui Huang, Jennifer Hadlock, and Cory Funk. 2023. “Integration of Multiple Single Cell Microglial Datasets Reveals Radial Differentiation into Long‐lived Substates Associated with Alzheimer’s Pathology.” Alzheimer’s & Dementia 19. https://doi.org/10.1002/alz.080693. Cite
Hwang, Yeon Mi, Qi Wei, Samantha N. Piekos, Bhargav Vemuri, Sevda Molani, Philip Mease, Leroy Hood, and Jennifer J. Hadlock. 2023. “Maternal-Fetal Outcomes in Patients with Immune Mediated Inflammatory Diseases, with Consideration of Comorbidities: A Retrospective Cohort Study in a Large U.S. Healthcare System.” MedRxiv: The Preprint Server for Health Sciences, 2023.08.07.23293726. https://doi.org/10.1101/2023.08.07.23293726. Cite Download
Piekos, Samantha N., Yeon Mi Hwang, Ryan T. Roper, Tanya Sorensen, Nathan D. Price, Leroy Hood, and Jennifer J. Hadlock. 2023. “Effect of COVID-19 Vaccination and Booster on Maternal-Fetal Outcomes: A Retrospective Cohort Study.” The Lancet. Digital Health 5 (9): e594–606. https://doi.org/10.1016/S2589-7500(23)00093-6. Cite Download
Wei, Qi, Philip J. Mease, Michael Chiorean, Lulu Iles-Shih, Wanessa F. Matos, Andrew Baumgartner, Sevda Molani, et al. 2023. “Risk Factors for Severe COVID-19 Outcomes: A Study of Immune-Mediated Inflammatory Diseases, Immunomodulatory Medications, and Comorbidities in a Large US Healthcare System.” MedRxiv: The Preprint Server for Health Sciences, 2023.06.26.23291904. https://doi.org/10.1101/2023.06.26.23291904. Cite Download
Fecho, Karamarie, Chris Bizon, Tursynay Issabekova, Sierra Moxon, Anne E. Thessen, Shervin Abdollahi, Sergio E. Baranzini, et al. 2023. “An Approach for Collaborative Development of a Federated Biomedical Knowledge Graph-Based Question-Answering System: Question-of-the-Month Challenges.” Journal of Clinical and Translational Science 7 (1): e214. https://doi.org/10.1017/cts.2023.619. Cite Download
Hwang, Yeon-Mi, Samantha Piekos, Tanya Sorensen, Leroy Hood, and Jennifer Hadlock. 2023. “Adoption of a National Prophylactic Anticoagulation Guideline for Hospitalized Pregnant Women with COVID-19: Retrospective Cohort Study.” JMIR Public Health and Surveillance. https://doi.org/10.2196/45586. Cite
Watanabe, Kengo, Tomasz Wilmanski, Christian Diener, John C. Earls, Anat Zimmer, Briana Lincoln, Jennifer J. Hadlock, et al. 2023. “Multiomic Signatures of Body Mass Index Identify Heterogeneous Health Phenotypes and Responses to a Lifestyle Intervention.” Nature Medicine 29 (4): 996–1008. https://doi.org/10.1038/s41591-023-02248-0. Cite Download
Hwang, Yeon Mi, Ryan T. Roper, Samantha N. Piekos, Daniel A. Enquobahrie, Mary F. Hebert, Alison G. Paquette, Priyanka Baloni, Nathan D. Price, Leroy Hood, and Jennifer J. Hadlock. 2023. “Timing of Selective Serotonin Reuptake Inhibitor Use and Risk for Preterm Birth and Related Adverse Events.” medRxiv. https://doi.org/10.1101/2023.03.03.23286717. Cite Download
Johnson, James P., Christian Diener, Anne E. Levine, Tomasz Wilmanski, David L. Suskind, Alexandra Ralevski, Jennifer Hadlock, et al. 2023. “Generally-Healthy Individuals with Aberrant Bowel Movement Frequencies Show Enrichment for Microbially-Derived Blood Metabolites Associated with Impaired Kidney Function.” bioRxiv. https://doi.org/10.1101/2023.03.04.531100. Cite Download
Molani, Sevda, Patricia V. Hernandez, Ryan T. Roper, Venkata R. Duvvuri, Andrew M. Baumgartner, Jason D. Goldman, Nilüfer Ertekin-Taner, et al. 2022. “Risk Factors for Severe COVID-19 Differ by Age for Hospitalized Adults.” Scientific Reports 12 (1): 6568. https://doi.org/10.1038/s41598-022-10344-3. Cite Download Download
Piekos, Samantha N., Nathan D. Price, Leroy Hood, and Jennifer J. Hadlock. 2022. “The Impact of Maternal SARS-CoV-2 Infection and COVID-19 Vaccination on Maternal-Fetal Outcomes.” Reproductive Toxicology (Elmsford, N.Y.), S0890-6238(22)00153-8. https://doi.org/10.1016/j.reprotox.2022.10.003. Cite
Kwasniewski, Miroslaw, Urszula Korotko, Karolina Chwialkowska, Magdalena Niemira, Jerzy Jaroszewicz, Barbara Sobala-Szczygiel, Beata Puzanowska, et al. 2022. “Implementation of the Web-Based Calculator Estimating Odds Ratio of Severe COVID-19 for Unvaccinated Individuals in a Country with High Coronavirus-Related Death Toll.” Allergy. https://doi.org/10.1111/all.15524. Cite Download
Molani, Sevda, Patricia V. Hernandez, Ryan T. Roper, Venkata R. Duvvuri, Andrew M. Baumgartner, Jason D. Goldman, Nilüfer Ertekin-Taner, et al. 2022. “Risk Factors for Severe COVID-19 Differ by Age: A Retrospective Study of Hospitalized Adults.” Preprint. Public and Global Health. https://doi.org/10.1101/2022.02.02.22270287. Cite Download
Mease, P. J., Q. Wei, M. Chiorean, L. Iles-Shih, and J. Hadlock. 2022. “Op0247 Risk Factors for Severe Covid-19 Outcomes: A Study of Immune-Mediated Inflammatory Diseases, Therapies and Comorbidities in a Large Us Healthcare System.” Annals of the Rheumatic Diseases 81 (Suppl 1): 161–62. https://doi.org/10.1136/annrheumdis-2022-eular.2163. Cite Download
Watanabe, Kengo, Tomasz Wilmanski, Christian Diener, Anat Zimmer, Briana Lincoln, Jennifer J. Hadlock, Jennifer C. Lovejoy, et al. 2022. “Multiomic Investigations of Body Mass Index Reveal Heterogeneous Trajectories in Response to a Lifestyle Intervention.” medRxiv. https://doi.org/10.1101/2022.01.20.22269601. Cite Download
Goldman, Jason D., Kai Wang, Katharina Röltgen, Sandra C. A. Nielsen, Jared C. Roach, Samia N. Naccache, Fan Yang, et al. 2022. “Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report.” Vaccines 11 (1): 5. https://doi.org/10.3390/vaccines11010005. Cite Download
Duvvuri, Venkata R., Andrew Baumgartner, Sevda Molani, Patricia V. Hernandez, Dan Yuan, Ryan T. Roper, Wanessa F. Matos, et al. 2022. “Angiotensin-Converting Enzyme (ACE) Inhibitors May Moderate COVID-19 Hyperinflammatory Response: An Observational Study with Deep Immunophenotyping.” Health Data Science 2022: 0002. https://doi.org/10.34133/hds.0002. Cite Download
Unni, Deepak R., Sierra A. T. Moxon, Michael Bada, Matthew Brush, Richard Bruskiewich, J. Harry Caufield, Paul A. Clemons, et al. 2022. “Biolink Model: A Universal Schema for Knowledge Graphs in Clinical, Biomedical, and Translational Science.” Clinical and Translational Science 15 (8): 1848–55. https://doi.org/10.1111/cts.13302. Cite Download
Fecho, Karamarie, Anne E. Thessen, Sergio E. Baranzini, Chris Bizon, Jennifer J. Hadlock, Sui Huang, Ryan T. Roper, et al. 2022. “Progress toward a Universal Biomedical Data Translator.” Clinical and Translational Science. https://doi.org/10.1111/cts.13301. Cite
Molani, Sevda, Andrew M. Baumgartner, Yeon Mi Hwang, Venkata R. Duvvuri, Jason D. Goldman, and Jennifer J. Hadlock. 2022. “Time to Reinfection and Vaccine Breakthrough SARS-CoV-2 Infections: A Retrospective Cohort Study,” 2022.02.07.22270613. https://www.medrxiv.org/content/10.1101/2022.02.07.22270613v1. Cite Download
Baumgartner, Andrew, Sevda Molani, Qi Wei, and Jennifer Hadlock. 2022. “Imputing Missing Observations with Time Sliced Synthetic Minority Oversampling Technique.” ArXiv:2201.05634 [Physics, q-Bio, Stat]. http://arxiv.org/abs/2201.05634. Cite Download
Piekos, Samantha N., Ryan T. Roper, Yeon Mi Hwang, Tanya Sorensen, Nathan D. Price, Leroy Hood, and Jennifer J. Hadlock. 2022. “The Effect of Maternal SARS-CoV-2 Infection Timing on Birth Outcomes: A Retrospective Multicentre Cohort Study.” The Lancet. Digital Health 4 (2): e95–104. https://doi.org/10.1016/S2589-7500(21)00250-8. Cite Download
Su, Yapeng, Dan Yuan, Daniel G. Chen, Rachel H. Ng, Kai Wang, Jongchan Choi, Sarah Li, et al. 2022. “Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae.” Cell 0 (0). https://doi.org/10.1016/j.cell.2022.01.014. Cite Download
Diaz, George A, Alyssa B Christensen, Tobias Pusch, Delaney Goulet, Shu-Ching Chang, Gary L Grunkemeier, Paul A McKelvey, et al. 2021. “Remdesivir and Mortality in Patients With Coronavirus Disease 2019.” Clinical Infectious Diseases, ciab698. https://doi.org/10.1093/cid/ciab698. Cite Download
Jiang, Yonghou, Fergal Duffy, Jennifer Hadlock, Andrew Raappana, Sheila Styrchak, Ingrid Beck, Fred D. Mast, et al. 2021. “Angiotensin II Receptor I Auto-Antibodies Following SARS-CoV-2 Infection.” PloS One 16 (11): e0259902. https://doi.org/10.1371/journal.pone.0259902. Cite Download
Lee, Jihoon W., Yapeng Su, Priyanka Baloni, Daniel Chen, Ana Jimena Pavlovitch-Bedzyk, Dan Yuan, Venkata R. Duvvuri, et al. 2021. “Integrated Analysis of Plasma and Single Immune Cells Uncovers Metabolic Changes in Individuals with COVID-19.” Nature Biotechnology. https://doi.org/10.1038/s41587-021-01020-4. Cite Download
Lee, Jewel Y., Sevda Molani, Chen Fang, Kathleen Jade, D. Shane O’Mahony, Sergey A. Kornilov, Lindsay T. Mico, and Jennifer J. Hadlock. 2021. “Ambulatory Risk Models for the Long-Term Prevention of Sepsis: Retrospective Study.” JMIR Medical Informatics 9 (7): e29986. https://doi.org/10.2196/29986. Cite Download
Su, Yapeng, Dan Yuan, Daniel G. Chen, Kai Wang, Jongchan Choi, Chengzhen L. Dai, Sunga Hong, et al. 2021. “Heterogeneous Immunological Recovery Trajectories Revealed in Post-Acute COVID-19.” MedRxiv, 2021.03.19.21254004. https://doi.org/10.1101/2021.03.19.21254004. Cite Download
Dai, Chengzhen L., Sergey A. Kornilov, Ryan T. Roper, Hannah Cohen-Cline, Kathleen Jade, Brett Smith, James R. Heath, et al. 2021. “Characteristics and Factors Associated with COVID-19 Infection, Hospitalization, and Mortality Across Race and Ethnicity.” Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. https://doi.org/10.1093/cid/ciab154. Cite Download
Goldman, Jason D., Kai Wang, Katharina Röltgen, Sandra C. A. Nielsen, Jared C. Roach, Samia N. Naccache, Fan Yang, et al. 2020. “Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: A Case Report.” https://www.medrxiv.org/content/10.1101/2020.09.22.20192443v1. Cite Download
Su, Yapeng, Daniel Chen, Dan Yuan, Christopher Lausted, Jongchan Choi, Chengzhen L. Dai, Valentin Voillet, et al. 2020. “Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.” Cell, S0092867420314446. https://doi.org/10.1016/j.cell.2020.10.037. Cite Download
Fecho, Karamarie, Stanley C. Ahalt, Saravanan Arunachalam, James Champion, Christopher G. Chute, Sarah Davis, Kenneth Gersing, et al. 2019. “Sex, Obesity, Diabetes, and Exposure to Particulate Matter among Patients with Severe Asthma: Scientific Insights from a Comparative Analysis of Open Clinical Data Sources during a Five-Day Hackathon.” Journal of Biomedical Informatics 100: 103325. https://doi.org/10.1016/j.jbi.2019.103325. Cite
Ahalt, Stanley C., Christopher G. Chute, Karamarie Fecho, Gustavo Glusman, Jennifer Hadlock, Casey Overby Taylor, Emily R. Pfaff, et al. 2019. “Clinical Data: Sources and Types, Regulatory Constraints, Applications.” Clinical and Translational Science. https://doi.org/10.1111/cts.12638. Cite Download
Robinson, Max, Jennifer Hadlock, Jiyang Yu, Alireza Khatamian, Aleksandr Y. Aravkin, Eric W. Deutsch, Nathan D. Price, Sui Huang, and Gustavo Glusman. 2018. “Fast and Simple Comparison of Semi-Structured Data, with Emphasis on Electronic Health Records.” BioRxiv, 293183. https://doi.org/10.1101/293183. Cite Download