James R. Heath, PhD

President & Professor

Jim Heath Headshot

Dr. James R. Heath is President and Professor at Institute for Systems Biology in Seattle. Heath also has the position of Professor of Molecular and Medical Pharmacology at UCLA, and he has directed the National Cancer Institute-funded NSB Cancer Center since 2005. Formerly, he was the Elizabeth W. Gilloon Professor of Chemistry at Caltech, and served as co-director of the Parker Institute for Cancer Immunotherapy at UCLA until 2017.

Heath received his PhD in 1988 from Rice University, where he was the principal graduate student involved in the discovery of C60 and the fullerenes — work that resulted in three senior members of his group receiving the Nobel Prize in Chemistry in 1996. He was a Miller Fellow at UC Berkeley before joining the research staff at IBM Watson Labs in 1991. He took a faculty position at UCLA in 1994, and moved to Caltech in 2003.

He has received several awards and honors, including the Irving Weinstein Award from the American Association of Cancer Researchers, and the Sackler Prize in the Physical Sciences. He was named one of the top seven innovators in the world by Forbes Magazine.

Heath has founded or cofounded several companies, including PACT Pharma, Integrated Diagnostics, Indi Molecular, CTI Molecular Imaging (acquired by Siemens in 2005), Sofie Biosciences, Isoplexis, and NanoSys.

President and Professor, Institute for Systems Biology, Seattle

Elizabeth W. Gilloon Professor & Professor of Chemistry, Caltech

Professor of Molecular & Medical Pharmacology, UCLA Health Sciences Center

Prof., UCLA;   1996-97, Assoc. Prof., UCLA;   1994-96, Asst. Prof., UCLA

1991 – 94  
Research Staff, IBM T.J. Watson Res. Labs, Yorktown, NY

UC Berkeley Miller Fellowship, Postdoctoral Scholar

Rice University, PhD, Chemistry

Rice University, MA, Chemistry

Baylor University, BSc, Chemistry

Ng, Rachel H., Jihoon W. Lee, Priyanka Baloni, Christian Diener, James R. Heath, and Yapeng Su. 2022. “Constraint-Based Reconstruction and Analyses of Metabolic Models: Open-Source Python Tools and Applications to Cancer.” Frontiers in Oncology 12: 914594. https://doi.org/10.3389/fonc.2022.914594. Cite Download
Manry, Jérémy, Paul Bastard, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Eleftherios Michailidis, et al. 2022. “The Risk of COVID-19 Death Is Much Greater and Age Dependent with Type I IFN Autoantibodies.” Proceedings of the National Academy of Sciences of the United States of America 119 (21): e2200413119. https://doi.org/10.1073/pnas.2200413119. Cite Download
Li, Jing, Maxim Zaslavsky, Yapeng Su, Jing Guo, Michael J. Sikora, Vincent van Unen, Asbjørn Christophersen, et al. 2022. “KIR+CD8+ T Cells Suppress Pathogenic T Cells and Are Active in Autoimmune Diseases and COVID-19.” Science 0 (0): eabi9591. https://doi.org/10.1126/science.abi9591. Cite Download
Su, Yapeng, Dan Yuan, Daniel G. Chen, Rachel H. Ng, Kai Wang, Jongchan Choi, Sarah Li, et al. 2022. “Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae.” Cell 0 (0). https://doi.org/10.1016/j.cell.2022.01.014. Cite Download
Ross, Mary Kay, Cyrus Raji, Kristine L. Lokken, Dale E. Bredesen, Jared C. Roach, Cory C. Funk, Nathan Price, Noa Rappaport, Leroy Hood, and James R. Heath. 2021. “Case Study: A Precision Medicine Approach to Multifactorial Dementia and Alzheimer’s Disease.” Journal of Alzheimer’s Disease & Parkinsonism 11 (Suppl 5): 018. Cite
Nesterenko, Pavlo A., Jami McLaughlin, Brandon L. Tsai, Giselle Burton Sojo, Donghui Cheng, Daniel Zhao, Zhiyuan Mao, et al. 2021. “HLA-A∗02:01 Restricted T Cell Receptors against the Highly Conserved SARS-CoV-2 Polymerase Cross-React with Human Coronaviruses.” Cell Reports 37 (13): 110167. https://doi.org/10.1016/j.celrep.2021.110167. Cite Download
Jung, Yugyung, Minkook Son, Yu Ri Nam, Jongchan Choi, James R. Heath, and Sung Yang. 2021. “Microfluidic Single-Cell Proteomics Assay Chip: Lung Cancer Cell Line Case Study.” Micromachines 12 (10): 1147. https://doi.org/10.3390/mi12101147. Cite Download
Jiang, Yonghou, Fergal Duffy, Jennifer Hadlock, Andrew Raappana, Sheila Styrchak, Ingrid Beck, Fred D. Mast, et al. 2021. “Angiotensin II Receptor I Auto-Antibodies Following SARS-CoV-2 Infection.” PloS One 16 (11): e0259902. https://doi.org/10.1371/journal.pone.0259902. Cite Download
Bastard, Paul, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Jérémy Manry, Eleftherios Michailidis, et al. 2021. “Autoantibodies Neutralizing Type I IFNs Are Present in ~4% of Uninfected Individuals over 70 Years Old and Account for ~20% of COVID-19 Deaths.” Science Immunology 6 (62): eabl4340. https://doi.org/10.1126/sciimmunol.abl4340. Cite Download
Lee, Jihoon W., Yapeng Su, Priyanka Baloni, Daniel Chen, Ana Jimena Pavlovitch-Bedzyk, Dan Yuan, Venkata R. Duvvuri, et al. 2021. “Integrated Analysis of Plasma and Single Immune Cells Uncovers Metabolic Changes in Individuals with COVID-19.” Nature Biotechnology. https://doi.org/10.1038/s41587-021-01020-4. Cite Download
Krämer, Benjamin, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, et al. 2021. “Early IFN-α Signatures and Persistent Dysfunction Are Distinguishing Features of NK Cells in Severe COVID-19.” Immunity, S1074-7613(21)00365-4. https://doi.org/10.1016/j.immuni.2021.09.002. Cite Download
Lu, Yue, Alphonsus H. C. Ng, Frances E. Chow, Richard G. Everson, Beth A. Helmink, Michael T. Tetzlaff, Rohit Thakur, et al. 2021. “Resolution of Tissue Signatures of Therapy Response in Patients with Recurrent GBM Treated with Neoadjuvant Anti-PD1.” Nature Communications 12 (1): 4031. https://doi.org/10.1038/s41467-021-24293-4. Cite Download
Idso, Matthew N., Bert T. Lai, Heather D. Agnew, and James R. Heath. 2021. “Protein Catalyzed Capture (PCC) Agents for Antigen Targeting.” Methods in Molecular Biology (Clifton, N.J.) 2371: 177–91. https://doi.org/10.1007/978-1-0716-1689-5_10. Cite
Su, Yapeng, Dan Yuan, Daniel G. Chen, Kai Wang, Jongchan Choi, Chengzhen L. Dai, Sunga Hong, et al. 2021. “Heterogeneous Immunological Recovery Trajectories Revealed in Post-Acute COVID-19.” MedRxiv, 2021.03.19.21254004. https://doi.org/10.1101/2021.03.19.21254004. Cite Download
Zheng, Hong, Aditya M. Rao, Denis Dermadi, Jiaying Toh, Lara Murphy Jones, Michele Donato, Yiran Liu, et al. 2021. “Multi-Cohort Analysis of Host Immune Response Identifies Conserved Protective and Detrimental Modules Associated with Severity across Viruses.” Immunity 54 (4): 753-768.e5. https://doi.org/10.1016/j.immuni.2021.03.002. Cite Download
Dai, Chengzhen L., Sergey A. Kornilov, Ryan T. Roper, Hannah Cohen-Cline, Kathleen Jade, Brett Smith, James R. Heath, et al. 2021. “Characteristics and Factors Associated with COVID-19 Infection, Hospitalization, and Mortality Across Race and Ethnicity.” Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. https://doi.org/10.1093/cid/ciab154. Cite Download
Goldman, Jason D., Kai Wang, Katharina Röltgen, Sandra C. A. Nielsen, Jared C. Roach, Samia N. Naccache, Fan Yang, et al. 2020. “Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: A Case Report.” https://www.medrxiv.org/content/10.1101/2020.09.22.20192443v1. Cite Download
Su, Yapeng, Guideng Li, Melissa Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Lidia Robert, et al. 2020. “Abstract 6585: Systems Biology for Investigating Drug Resistance Mechanism of Melanoma.” Cancer Research 80 (16 Supplement): 6585–6585. https://doi.org/10.1158/1538-7445.AM2020-6585. Cite
Chuntova, Pavlina, Frances Chow, Payal Watchmaker, Mildred Galvez, Amy B. Heimberger, Evan W. Newell, Aaron Diaz, et al. 2020. “Unique Challenges for Glioblastoma Immunotherapy - Discussions across Neuro-Oncology and Non-Neuro-Oncology Experts in Cancer Immunology.” Neuro-Oncology. https://doi.org/10.1093/neuonc/noaa277. Cite
Du, Jiajun, Yapeng Su, Chenxi Qian, Dan Yuan, Kun Miao, Dongkwan Lee, Alphonsus H. C. Ng, et al. 2020. “Raman-Guided Subcellular Pharmaco-Metabolomics for Metastatic Melanoma Cells.” Nature Communications 11 (1): 4830. https://doi.org/10.1038/s41467-020-18376-x. Cite Download
Wells, Daniel K., Marit M. van Buuren, Kristen K. Dang, Vanessa M. Hubbard-Lucey, Kathleen C. F. Sheehan, Katie M. Campbell, Andrew Lamb, et al. 2020. “Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction.” Cell 183 (3): 818-834.e13. https://doi.org/10.1016/j.cell.2020.09.015. Cite
Heath, James R. 2020. “Interdisciplinary Profile: An Established Chemist Journeys into Different Disciplines.” IScience 23 (5): 101088. https://doi.org/10.1016/j.isci.2020.101088. Cite Download
Su, Yapeng, Daniel Chen, Dan Yuan, Christopher Lausted, Jongchan Choi, Chengzhen L. Dai, Valentin Voillet, et al. 2020. “Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.” Cell, S0092867420314446. https://doi.org/10.1016/j.cell.2020.10.037. Cite Download
Idso, Matthew N., Ajay Suresh Akhade, Mario L. Arrieta-Ortiz, Bert T. Lai, Vivek Srinivas, James P. Hopkins, Ana Oliveira Gomes, Naeha Subramanian, Nitin Baliga, and James R. Heath. 2020. “Antibody-Recruiting Protein-Catalyzed Capture Agents to Combat Antibiotic-Resistant Bacteria.” Chemical Science 11 (11): 3054–67. https://doi.org/10.1039/C9SC04842A. Cite Download Download
Su, Yapeng, Melissa E. Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica Wang, Jihoon W. Lee, et al. 2020. “Multi-Omic Single-Cell Snapshots Reveal Multiple Independent Trajectories to Drug Tolerance in a Melanoma Cell Line.” Nature Communications 11 (1): 2345. https://doi.org/10.1038/s41467-020-15956-9. Cite Download
Heath, James R. 2019. “Framing Technology Challenges Associated with Improving Cancer Immunotherapies.” Lab on a Chip 19 (20): 3366–67. https://doi.org/10.1039/c9lc90103e. Cite
Lu, Yue, Byung-Kuk Yoo, Alphonsus H. C. Ng, Jungwoo Kim, Sinchul Yeom, Jau Tang, Milo M. Lin, Ahmed H. Zewail, and James R. Heath. 2019. “4D Electron Microscopy of T Cell Activation.” Proceedings of the National Academy of Sciences of the United States of America 116 (44): 22014–19. https://doi.org/10.1073/pnas.1914078116. Cite
Zhu, Yanni, Drake J. Smith, Yang Zhou, Yan-Ruide Li, Jiaji Yu, Derek Lee, Yu-Chen Wang, et al. 2019. “Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.” Cell Stem Cell 25 (4): 542-557.e9. https://doi.org/10.1016/j.stem.2019.08.004. Cite
Ng, Alphonsus H. C., Songming Peng, Alexander M. Xu, Won Jun Noh, Katherine Guo, Michael T. Bethune, William Chour, et al. 2019. “MATE-Seq: Microfluidic Antigen-TCR Engagement Sequencing.” Lab on a Chip 19 (18): 3011–21. https://doi.org/10.1039/C9LC00538B. Cite Download
Su, Yapeng, Guideng Li, Melissa E. Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica Wang, et al. 2019. “Trajectories from Snapshots: Integrated Proteomic and Metabolic Single-Cell Assays Reveal Multiple Independent Adaptive Responses to Drug Tolerance in a BRAF-Mutant Melanoma Cell Line.” BioRxiv, 767988. https://doi.org/10.1101/767988. Cite Download
Liang, JingXin, David N. Bunck, Anvita Mishra, Sunga Hong, Matthew N. Idso, and James R. Heath. 2019. “Inhibition of Heme Sequestration of Histidine-Rich Protein 2 Using Multiple Epitope-Targeted Peptides.” Journal of Peptide Science: An Official Publication of the European Peptide Society 25 (9): e3203. https://doi.org/10.1002/psc.3203. Cite
Peng, Songming, Jesse M. Zaretsky, Alphonsus H. C. Ng, William Chour, Michael T. Bethune, Jongchan Choi, Alice Hsu, et al. 2019. “Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood.” Cell Reports 28 (10): 2728-2738.e7. https://doi.org/10.1016/j.celrep.2019.07.106. Cite
Su, Yapeng, Marcus Bintz, Yezi Yang, Lidia Robert, Alphonsus H. C. Ng, Victoria Liu, Antoni Ribas, James R. Heath, and Wei Wei. 2019. “Phenotypic Heterogeneity and Evolution of Melanoma Cells Associated with Targeted Therapy Resistance.” PLoS Computational Biology 15 (6): e1007034. https://doi.org/10.1371/journal.pcbi.1007034. Cite Download
Agnew, Heather D., Matthew B. Coppock, Matthew N. Idso, Bert T. Lai, JingXin Liang, Amy M. McCarthy-Torrens, Carmen M. Warren, and James R. Heath. 2019. “Protein-Catalyzed Capture Agents.” Chemical Reviews. https://doi.org/10.1021/acs.chemrev.8b00660. Cite
Wen, Patrick Y., Mehdi Touat, Brian M. Alexander, Ingo K. Mellinghoff, Shakti Ramkissoon, Christine S. McCluskey, Kristine Pelton, et al. 2019. “Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.” Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, JCO1801207. https://doi.org/10.1200/JCO.18.01207. Cite
Xu, Alexander M., Qianhe Liu, Kaitlyn L. Takata, Sarah Jeoung, Yapeng Su, Igor Antoshechkin, Sisi Chen, Matthew Thomson, and James R. Heath. 2018. “Integrated Measurement of Intracellular Proteins and Transcripts in Single Cells.” Lab on a Chip. https://doi.org/10.1039/c8lc00639c. Cite
McCarthy, Amy M., Jungwoo Kim, A. Katrine Museth, Ryan K. Henning, John E. Heath, Emma Winson, Joseph J. Oh, Jingxin Liang, Sunga Hong, and James R. Heath. 2018. “Allosteric Inhibitor of KRas Identified Using a Barcoded Assay Microchip Platform.” Analytical Chemistry 90 (15): 8824–30. https://doi.org/10.1021/acs.analchem.8b00706. Cite Download
Sibener, Leah V., Ricardo A. Fernandes, Elizabeth M. Kolawole, Catherine B. Carbone, Fan Liu, Darren McAffee, Michael E. Birnbaum, et al. 2018. “Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.” Cell 174 (3): 672-687.e27. https://doi.org/10.1016/j.cell.2018.06.017. Cite Download
Li, Zhonghan, Hanjun Cheng, Shiqun Shao, Xiang Lu, Li Mo, Jonathan Tsang, Pu Zeng, et al. 2018. “Surface Immobilization of Redox-Labile Fluorescent Probes: Enabling Single-Cell Co-Profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities.” Angewandte Chemie (International Ed. in English). https://doi.org/10.1002/anie.201803034. Cite
Su, Yapeng, Wei Wei, Lidia Robert, Min Xue, Jennifer Tsoi, Angel Garcia-Diaz, Blanca Homet Moreno, et al. 2017. “Single-Cell Analysis Resolves the Cell State Transition and Signaling Dynamics Associated with Melanoma Drug-Induced Resistance.” Proceedings of the National Academy of Sciences of the United States of America 114 (52): 13679–84. https://doi.org/10.1073/pnas.1712064115. Cite
Tang, Yin, Zhuo Wang, Ziming Li, Jungwoo Kim, Yuliang Deng, Yan Li, James R. Heath, Wei Wei, Shun Lu, and Qihui Shi. 2017. “High-Throughput Screening of Rare Metabolically Active Tumor Cells in Pleural Effusion and Peripheral Blood of Lung Cancer Patients.” Proceedings of the National Academy of Sciences of the United States of America 114 (10): 2544–49. https://doi.org/10.1073/pnas.1612229114. Cite
Xue, Min, Wei Wei, Yapeng Su, Dazy Johnson, and James R. Heath. 2016. “Supramolecular Probes for Assessing Glutamine Uptake Enable Semi-Quantitative Metabolic Models in Single Cells.” Journal of the American Chemical Society 138 (9): 3085–93. https://doi.org/10.1021/jacs.5b12187. Cite
Wei, Wei, Young Shik Shin, Min Xue, Tomoo Matsutani, Kenta Masui, Huijun Yang, Shiro Ikegami, et al. 2016. “Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma.” Cancer Cell 29 (4): 563–73. https://doi.org/10.1016/j.ccell.2016.03.012. Cite
Xue, Min, Wei Wei, Yapeng Su, Jungwoo Kim, Young Shik Shin, Wilson X. Mai, David A. Nathanson, and James R. Heath. 2015. “Chemical Methods for the Simultaneous Quantitation of Metabolites and Proteins from Single Cells.” Journal of the American Chemical Society 137 (12): 4066–69. https://doi.org/10.1021/jacs.5b00944. Cite
Yu, Jing, Jing Zhou, Alex Sutherland, Wei Wei, Young Shik Shin, Min Xue, and James R. Heath. 2014. “Microfluidics-Based Single-Cell Functional Proteomics for Fundamental and Applied Biomedical Applications.” Annual Review of Analytical Chemistry 7 (1): 275–95. https://doi.org/10.1146/annurev-anchem-071213-020323. Cite
Yu, Jing, Jing Zhou, Alex Sutherland, Wei Wei, Young Shik Shin, Min Xue, and James R. Heath. 2014. “Microfluidics-Based Single-Cell Functional Proteomics for Fundamental and Applied Biomedical Applications.” Annual Review of Analytical Chemistry (Palo Alto, Calif.) 7: 275–95. https://doi.org/10.1146/annurev-anchem-071213-020323. Cite
Wei, Wei, Qihui Shi, Francoise Remacle, Lidong Qin, David B. Shackelford, Young Shik Shin, Paul S. Mischel, R. D. Levine, and James R. Heath. 2013. “Hypoxia Induces a Phase Transition within a Kinase Signaling Network in Cancer Cells.” Proceedings of the National Academy of Sciences of the United States of America 110 (15): E1352-1360. https://doi.org/10.1073/pnas.1303060110. Cite
Wei, Wei, Young Shik Shin, Chao Ma, Jun Wang, Meltem Elitas, Rong Fan, and James R. Heath. 2013. “Microchip Platforms for Multiplex Single-Cell Functional Proteomics with Applications to Immunology and Cancer Research.” Genome Medicine 5 (8): 75. https://doi.org/10.1186/gm479. Cite Download
Wang, Jun, Douglas Tham, Wei Wei, Young Shik Shin, Chao Ma, Habib Ahmad, Qihui Shi, Jenkan Yu, Raphael D. Levine, and James R. Heath. 2012. “Quantitating Cell–Cell Interaction Functions with Applications to Glioblastoma Multiforme Cancer Cells.” Nano Letters 12 (12): 6101–6. https://doi.org/10.1021/nl302748q. Cite
Shi, Qihui, Lidong Qin, Wei Wei, Feng Geng, Rong Fan, Young Shik Shin, Deliang Guo, Leroy Hood, Paul S. Mischel, and James R. Heath. 2012. “Single-Cell Proteomic Chip for Profiling Intracellular Signaling Pathways in Single Tumor Cells.” Proceedings of the National Academy of Sciences 109 (2): 419–24. https://doi.org/10.1073/pnas.1110865109. Cite Download