Alice Kane started as ISB’s Ling/Obrzut Assistant Professor in the Fall of 2022. Kane completed her PhD at the University of Sydney in 2016 under the supervision of Sarah Hilmer, where she explored the effect of frailty and aging on acetaminophen hepatotoxicity. She began her postdoctoral training in the lab of Susan Howlett at Dalhousie University, where she optimized frailty assessments in mice, explored sex differences in frailty and investigated the effect of frailty on cardiovascular aging. In 2018, Kane was awarded an Australian NHMRC CJ Martin Biomedical Fellowship to join the lab of David Sinclair at Harvard Medical School. In the Sinclair Lab, her work focused on the development of predictive frailty models for age and lifespan in mice, and the characterization of longitudinal frailty and health in both accelerated and delayed aging mouse models. She is currently supported by an NIA K99/R00 Transition to Independence award.
Kane’s research program aims to investigate the biological determinants of frailty in both sexes, using an integrated approach across physiological, molecular and computational techniques. She is particularly focused on the association between frailty and epigenetic changes in age, the use of large-scale longitudinal phenotyping in aging mouse studies, and the development of novel predictive biomarkers of frailty for mice and humans.
Frailty, aging, mouse models, epigenetics, DNA methylation, biomarkers
2010, BSc Adv Hons I, Pharmacology and Chemistry, University of Sydney
2016, PhD, Medicine, University of Sydney