ISB News

The Institute for Systems Biology (ISB) has been awarded a 2025 AWS Imagine Grant — funding that will accelerate the development of its generative-AI platform Tarpon, which creates “digital fingerprints” of T-cell receptors, enabling faster discovery and design of targeted immunotherapies.

This feature traces the remarkable arc of Mary Brunkow — from undergraduate at the University of Washington to 2025 Nobel Laureate — spotlighting her foundational discovery of the gene FOXP3, and how that breakthrough unlocked a new understanding of immune-system self-tolerance. The story also reflects on the years of basic research, the long-standing impact on immunology, and how Brunkow’s journey connects back to her roots in Seattle’s scientific community.

ISB-led research from the Gibbons Lab shows that how often people have bowel movements is linked to overall health and disease risk. The study suggests an optimal “Goldilocks” range of once or twice daily, with deviations associated with broader physiological changes.

ISB’s Dr. Sean Gibbons explores the science of bowel habits and the microbiome, explaining how frequency, timing, and stool form reflect overall health. The conversation connects everyday experiences with cutting-edge research on digestion, diet, and the trillions of microbes that shape human well-being.

Dr. Lee Hood joined podcast host Jeremy Koenig to discuss the evolution of medicine from reactive care to P4 health. He explored eight paradigm shifts that have transformed biology and highlighted how systems thinking, big data, and AI are reshaping wellness and personalized care.

University of Washington alum Mary Brunkow has been awarded the 2025 Nobel Prize in Physiology or Medicine for pioneering research into how the immune system is prevented from attacking the body’s own tissues – work that has profound implications for autoimmune disease, cancer therapies, and transplant medicine.