Drs. Jim Heath, Yapeng Su and Jihoon Lee

Metabolic Changes in Plasma and Immune Cells Associated with COVID-19 Severity, May Predict Patient Survival

Researchers from Institute for Systems Biology (ISB), Fred Hutchinson Cancer Research Center and other organizations have uncovered underlying metabolic changes that regulate how immune cells react to COVID-19. These findings are associated with COVID-19 severity and may predict patient survival. The work was published in the journal Nature Biotechnology.

Metabolic Changes in Plasma and Immune Cells Associated with COVID-19 Severity, May Predict Patient Survival
Metabolic Changes in Plasma and Immune Cells Associated with COVID-19 Severity, May Predict Patient Survival
Jennifer Hadlock, Andrew Magis and Chengzhen Dai

COVID-19 Outcome Disparities Across Racial/Ethnic Lines

ISB researchers and their collaborators looked at the electronic health records of nearly 630,000 patients who were tested for SARS-CoV-2, and found stark disparities in COVID-19 outcomes — odds of infection, hospitalization, and in-hospital mortality — between White and non-White minority racial and ethnic groups.

COVID-19 Outcome Disparities Across Racial/Ethnic Lines
COVID-19 Outcome Disparities Across Racial/Ethnic Lines
screenshot of video for Drs. Anthony Fauci, Lee Hood Talk COVID-19, Vaccines, Future of Research, More

Drs. Anthony Fauci, Lee Hood Talk COVID-19, Vaccines, Future of Research, More

NIAID Director Dr. Anthony Fauci sat down for a conversation with ISB's Dr. Lee Hood. The renowned scientists spoke about the importance of basic research, the extraordinary speed of COVID research, the efficacy of mRNA vaccines on COVID-19, lessons learned from the COVID-19 pandemic, and much more. 

Drs. Anthony Fauci, Lee Hood Talk COVID-19, Vaccines, Future of Research, More
Drs. Anthony Fauci, Lee Hood Talk COVID-19, Vaccines, Future of Research, More
Baliga, Peterson and Srinivas

ISB Creates PerSort, a New Cell Sorting Technology Aimed at Studying Drug Tolerance and Shortening Tuberculosis Treatment

ISB researchers Dr. Nitin Baliga, Dr. Eliza Peterson and Dr. Vivek Srinivas have developed a new cell sorting technology, called PerSort, that isolates and characterizes dormant persisters that exist in cultures of Mycobacterium tuberculosis, the pathogen that causes tuberculosis.

ISB Creates PerSort, a New Cell Sorting Technology Aimed at Studying Drug Tolerance and Shortening Tuberculosis Treatment
ISB Creates PerSort, a New Cell Sorting Technology Aimed at Studying Drug Tolerance and Shortening Tuberculosis Treatment
Subramanian and Akhade

How Salmonella Co-Opts the Host Immune System to Conceal Itself

While scientists have long studied bacterial infections, less attention has been paid to how the host immune response affects bacterial gene expression in the body. In a just-published paper in PNAS, ISB researchers detailed how the bacterium Salmonella conceals itself from the host immune system.

How Salmonella Co-Opts the Host Immune System to Conceal Itself
How Salmonella Co-Opts the Host Immune System to Conceal Itself
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