Innovator Awardees and Projects
2020
Focus Areas:
Proposals with novel approaches to address the questions identified below were encouraged.
Scientific Research Proposals:
- How does the gut microbiome modulate host responses to drugs/diet/lifestyle?
- How do you quantify relationships between Alzheimer’s Disease (AD) and the immune system?
- How do you extract disease-specific information from data clouds?
- How do you link electronic health records (EHR) to causal mechanistic underpinnings of disease?
- What are the differences between men and women’s response to multi-modal AD therapy or rates of Sepsis?
- How do you identify novel risk factors (such as exposures, phenotypes, EHR) to predict risk to inform better care decisions?
- How do you develop systems biology tools to characterize cell state transitions in health and disease?
- How do you integrate multi-modal imaging and molecular data with machine learning approaches for predictive clinical decision making?
- How would you develop a program to mine drug databases (DrugBank, SIDER, Pharao, GINA, etc) for side effects that could be used for drug repurposing (example: Viagra)?
- How is cancer progression correlated with co-morbidities?
- Proposals that leverage ISB’s resources (biobanks Arivale software platforms, EHR records, etc.) are encouraged. A list of resources can be found here.
Education proposals:
- How can we scale ISB Education’s programs?
- How can we develop physical toys that convey in an intuitive manner emergent properties to high-school students?
Awardees:
Lead Investigator: Cheng Dai
ISB Collaborators: Brett Smith, Ryan Roper, Jewel Lee, Alison Paquette
Project Title: Incorporating health-related social needs and social determinants into electronic health records to promote population health
View the proposal and review (internal use only)
Lead Investigator: Jen Eklund
ISB Collaborators: Becky Howsmon, Dave Gibbs, Noa Rappaport, Rachel Calder
Project Title: Exploring Stability and Change in Education Data
View the proposal and review (internal use only)
Lead Investigator: Jie Luo
ISB Collaborators: Marlee Ng, Jacob Bassett
Project Title: Development of 3’dCDP-DAG prodrug for antiviral treatment
View the proposal and review (internal use only)
2019
Focus Areas:
- Multiscale interactions
- Quantitative definition of uniqueness and states
- Concept to classroom
Awardees:
Lead Investigator: Jacob Valenzuela (Baliga Group)
ISB Collaborators: Becky Howsmon, Wei-ju Wu, Nyasha Chambwe, and Jen Eklund
Project Title: Central Dogma–The development of an interactive gaming pipeline that teaches critical STEM concepts directly to the classroom
View the proposal and review (internal use only)
Lead investigator: Shiqun Shao (Wei Group)
ISB Collaborators: Dan Yuan and Chunmei Liu
Project Title: Development of A Massively Parallel Single-cell ChIP-Seq Technology
View the proposal and review (internal use only)
Lead Investigator: Shizhen Qin (Hood-Price Group)
ISB Collaborators: Christian Diener, Sushmita Patwardhan, Yong Zhou, Li Tang, Gustavo Glusman, and John Earls
Project Title: Integrating genetics, blood proteomics and the gut microbiome to understand transitions from high to lower weights
View the proposal and review (internal use only)
2018
Focus Areas:
- Novel experimental systems
- Therapeutics/interventions
- Diagnostics
- Tracking spatiotemporal heterogeneity of biological phenomena
Awardees:
Lead investigator: Matt Idso (Heath Group)
Collaborators: Mario Arrieta-Ortiz (Baliga Group), Ajay Akhade (Subramanian Group)
Project title: Peptide-based immunotherapeutics to combat drug-resistant bacteria
View the proposal and review (internal use only)
Lead investigator: John Earls (Hood-Price Group)
Collaborators: Theo Knijnenburg (Shmulevich Group), Michael Strasser (Huang Group)
Project Title: High-throughput Artificial Neural Net Architecture for Health using pD3 clouds
View the proposal and review (internal use only)
Lead investigator: Yapeng Su (Heath Group)
Collaborators: Joseph Zhou (Huang Group), Theo Knijnenburg (Shmulevich Group), John Earls (Hood-Price Group), Alphonsus Ng (Heath Group), Priyanka Baloni (Hood-Price Group)
Project Title: Model driven discovery of central ligand-receptor pairs that maintain the drug resistance of a tumor cell ecosystem community
View the proposal and review (internal use only)
Lead investigator: Adrian Lopez Garcia De Lomana (Baliga Group)
Collaborators: Martin Shelton (Hood-Price Group), Chris Lausted (Hood-Price Group), Jessica Day (Baliga Group)
Project Title: One day of HIV infection one cell at a time
View the proposal and review (internal use only)
2017
Focus Areas:
- Single cell analytics
- Interactomics
- Genome editing
- Big data analytics & modeling
Awardees:
Lead investigator: Chris Lausted (Hood-Price Group)
Collaborators: Neda Jabbari (Hood-Price Group), Changting Meng (Hood-Price Group), Vesteinn Thorsson (Shmulevich Group)
Project title: Sequence of the COLO320 double minute chromosome and its effect on gene expression
Lead investigator: Eliza Peterson (Baliga Group)
Collaborators: Eliza Peterson (Baliga Group), Mark Gillespie (Ranish Group), Fred Mast (Aitchison Group)
Project title: High-Throughput Analysis of Regulatory Interactions in Mycobacterium Tuberculosis
Lead investigator: Joseph Zhou (Huang Group)
Collaborators: Irit Ruben (Huang Group), Chris Lausted (Hood-Price Group), Theo Knijnenberg (Shmulevich Group)
Project title: A Novel Technique to Monitor Single-Cell Transcriptome over Time Using Barcoding