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Naeha Subramanian, PhD

Associate Professor

ISB

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  • Biography
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Naeha Subramanian is an Associate Professor at the Institute for Systems Biology and Affiliate Associate Professor in the Department of Immunology and Department of Global Health at the University of Washington. She received her PhD in Immunology under the mentorship of Dr. Ayub Qadri at the National Institute of Immunology in New Delhi. She then completed her postdoctoral training in Dr. Ron Germain’s laboratory at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). She is the recipient of the G.P. Talwar Medal for Best PhD Thesis (2009), NIAID Merit Award (2011), NIH Director’s Award (2012) and NIAID Performance Award (2014) in recognition of research excellence.

Naeha’s research interests lie in the molecular mechanisms of innate immunity and its role in host defense against pathogens and development of immune disease. The lab also works in the area of human immunology – especially systems-level studies of the immune response in patients with Lyme Disease. Her lab’s main focus is to investigate the function and regulation of a class of intracellular sensors called the NOD-like receptors (NLRs) in health, infectious disease, and complex immune-mediated disorders like cancer and autoimmunity.

PhD, Immunology, National Institute of Immunology, New Delhi

Immunology, innate immunity, host-pathogen interactions
Akhade, Ajay Suresh, and Naeha Subramanian. 2023. “Cytoplasmic Sensing in Innate Immunity.” In Encyclopedia of Cell Biology (Second Edition), edited by Ralph A. Bradshaw, Gerald W. Hart, and Philip D. Stahl, 624–43. Oxford: Academic Press. https://doi.org/10.1016/B978-0-12-821618-7.00012-2. Cite
Akhade, Ajay Suresh, Gabriela Verdezoto Mosquera, Mario L Arrieta-Ortiz, Amardeep Kaur, Eliza J.R Peterson, Nitin S Baliga, Kelly T Hughes, and Naeha Subramanian. 2022. “A Non-Canonical Role of Caspase-1 in Regulating Bacterial Physiology and Antimicrobial Resistance.” The Journal of Immunology 208 (1_Supplement): 51.05. https://doi.org/10.4049/jimmunol.208.Supp.51.05. Cite
Kuchina, Anna, Jason Yang, Bree Aldridge, Kevin A. Janes, Naeha Subramanian, Nevan J. Krogan, Mehdi Bouhaddou, Shirit Einav, Jason Papin, and Ronald N. Germain. 2022. “How Can Systems Approaches Help Us Understand and Treat Infectious Disease?” Cell Systems 13 (12): 945–49. https://doi.org/10.1016/j.cels.2022.11.009. Cite
Duvvuri, Venkata R., Andrew Baumgartner, Sevda Molani, Patricia V. Hernandez, Dan Yuan, Ryan T. Roper, Wanessa F. Matos, et al. 2022. “Angiotensin-Converting Enzyme (ACE) Inhibitors May Moderate COVID-19 Hyperinflammatory Response: An Observational Study with Deep Immunophenotyping.” Health Data Science 2022:0002. https://doi.org/10.34133/hds.0002. Cite Download
Su, Yapeng, Dan Yuan, Daniel G. Chen, Rachel H. Ng, Kai Wang, Jongchan Choi, Sarah Li, et al. 2022. “Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae.” Cell 0 (0). https://doi.org/10.1016/j.cell.2022.01.014. Cite Download
Rommereim, Leah, Ajay Suresh Akhade, Ronald N. Germain, Iain D. C. Fraser, and Naeha Subramanian. 2021. “Lentivirus-Mediated Conditional Gene Expression.” Bio-Protocol 11 (21): e4205. https://doi.org/10.21769/BioProtoc.4205. Cite
Su, Yapeng, Dan Yuan, Daniel G. Chen, Kai Wang, Jongchan Choi, Chengzhen L. Dai, Sunga Hong, et al. 2021. “Heterogeneous Immunological Recovery Trajectories Revealed in Post-Acute COVID-19.” MedRxiv, 2021.03.19.21254004. https://doi.org/10.1101/2021.03.19.21254004. Cite Download
Rommereim, Leah M., Ajay Suresh Akhade, Bhaskar Dutta, Carolyn Hutcheon, Nicolas W. Lounsbury, Clifford C. Rostomily, Ram Savan, Iain D. C. Fraser, Ronald N. Germain, and Naeha Subramanian. 2020. “A Small Sustained Increase in NOD1 Abundance Promotes Ligand-Independent Inflammatory and Oncogene Transcriptional Responses.” Science Signaling 13 (661). https://doi.org/10.1126/scisignal.aba3244. Cite Download
Akhade, Ajay Suresh, Shaikh M. Atif, Bhavana S. Lakshmi, Neha Dikshit, Kelly T. Hughes, Ayub Qadri, and Naeha Subramanian. 2020. “Type 1 Interferon-Dependent Repression of NLRC4 and IPLA2 Licenses down-Regulation of Salmonella Flagellin inside Macrophages.” Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2002747117. Cite Download
Su, Yapeng, Daniel Chen, Dan Yuan, Christopher Lausted, Jongchan Choi, Chengzhen L. Dai, Valentin Voillet, et al. 2020. “Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.” Cell, S0092867420314446. https://doi.org/10.1016/j.cell.2020.10.037. Cite Download
Idso, Matthew N., Ajay Suresh Akhade, Mario L. Arrieta-Ortiz, Bert T. Lai, Vivek Srinivas, James P. Hopkins, Ana Oliveira Gomes, Naeha Subramanian, Nitin Baliga, and James R. Heath. 2020. “Antibody-Recruiting Protein-Catalyzed Capture Agents to Combat Antibiotic-Resistant Bacteria.” Chemical Science 11 (11): 3054–67. https://doi.org/10.1039/C9SC04842A. Cite Download Download
Hampton, Henry, Carolyn Hutcheon, and Naeha Subramanian. 2016. “NAGging Hexokinase PEPs up NLRP3.” Cell Host & Microbe 20 (2): 130–32. https://doi.org/10.1016/j.chom.2016.07.017. Cite Download
Rommereim, L. M., and Naeha Subramanian. 2015. “AIMing 2 Curtail Cancer.” Cell 162 (July):18–20. https://doi.org/10.1016/j.cell.2015.06.041. Cite Download
Hutcheon, C., D. Paulvannan, and Naeha Subramanian. 2015. “Cyoplasmic Sensing in Innate Immunity.” In Encyclopedia of Cell Biology, Vol.3:Pages 710-726. https://www.elsevier.com/books/encyclopedia-of-cell-biology/bradshaw/978-0-12-394447-4. Cite Download
Subramanian, Naeha, Kannan Natarajan, Menna R. Clatworthy, Ze Wang, and Ronald N. Germain. 2013. “The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation.” Cell 153 (April):348–61. https://doi.org/10.1016/j.cell.2013.02.054. Cite Download
Lee, Geun-Shik, Naeha Subramanian, Andrew I. Kim, Ivona Aksentijevich, Raphaela Goldbach-Mansky, David B. Sacks, Ronald N. Germain, Daniel L. Kastner, and Jae Jin Chae. 2012. “The Calcium-Sensing Receptor Regulates the NLRP3 Inflammasome through Ca2+ and CAMP.” Nature 492 (December):123–27. https://doi.org/10.1038/nature11588. Cite Download
Kastenmüller, Wolfgang, Parizad Torabi-Parizi, Naeha Subramanian, Tim Lämmermann, and Ronald N. Germain. 2012. “A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread.” Cell 150 (September):1235–48. https://doi.org/10.1016/j.cell.2012.07.021. Cite Download
Ombrello, Michael J., Elaine F. Remmers, Guangping Sun, Alexandra F. Freeman, Shrimati Datta, Parizad Torabi-Parizi, Naeha Subramanian, et al. 2012. “Cold Urticaria, Immunodeficiency, and Autoimmunity Related to PLCG2 Deletions.” N Engl J Med 366 (January):330–38. https://doi.org/10.1056/NEJMoa1102140. Cite Download
Kastenmüller, Wolfgang, Georg Gasteiger, Naeha Subramanian, Tim Sparwasser, Dirk H. Busch, Yasmine Belkaid, Ingo Drexler, and Ronald N. Germain. 2011. “Regulatory T Cells Selectively Control CD8+ T Cell Effector Pool Size via IL-2 Restriction.” J Immunol 187 (September):3186–97. https://doi.org/10.4049/jimmunol.1101649. Cite Download
Subramanian, Naeha, and Ayub Qadri. 2006. “Lysophospholipid Sensing Triggers Secretion of Flagellin from Pathogenic Salmonella.” Nat Immunol 7 (June):583–89. https://doi.org/10.1038/ni1336. Cite Download