Dr. Kusebauch’s research activities include the development and application of proteomic technologies, with a particular focus on targeted proteomics in biomedical research. Dr. Kusebauch studied Pharmaceutical Chemistry and obtained her Ph.D. in Biochemistry at the Max Planck Institute of Biochemistry (Germany) focusing on peptide/organic chemistry and conformational studies at temporal resolution. For her postdoctoral work, she joined the group of Prof. Ruedi Aebersold where she contributed to the development of targeted proteomics by selected reaction monitoring (SRM).
Dr. Kusebauch continued her research at ISB where she developed complete proteome SRM and SWATH mass spectrometry resources for human and other organisms, e.g., the Human SRMAtlas (www.srmatlas.org), a public available resource of targeted assays to quantify any protein in the human proteome, and applies quantitative technologies to spatial and temporal proteome dynamics and biochemical mechanisms in infectious and chronic human diseases. Other work includes the discovery of tyrosine phosphorylation in Mycobacterium tuberculosis revealing a previously unrecognized post-translational modification system in a human pathogen that claims ∼1.4 million lives every year. Dr. Kusebauch received the Human Proteome Organization Discovery in Proteomics Sciences Award 2018 that recognizes the outstanding efforts and achievements of individuals in the field of proteomics.
Proteomics, Mass Spectrometry, Post-translational Modification (PTM’s), Protein Biochemistry, Systems Biology, Peptide Chemistry, Pharmaceutical Chemistry
Kusebauch U, Hernández-Castellano LE, Bislev SL, Moritz RL, Røntved CM, Bendixen E, Selected reaction monitoring mass spectrometry of mastitis milk reveals pathogen-specific regulation of bovine host-response proteins, J Dairy Sci, 2018, 101(7), 6532–6541, PMID: 29655560.
Price ND, Magis AT, Earls JC, Glusman G, Levy R, Lausted C, McDonald DT, Kusebauch U, Moss, CL, Zhou Y, Qin S, Moritz RL, Brogaard K, Omenn GS, Lovejoy JC, Hood L, Analysis of dense, dynamic, personal data clouds for 108 humans in a 9-month wellness study, Nature Biotechnology, 2017, 35(8), 747-756. PMID: 28714965.
Kusebauch U, Campbell DS, Deutsch EW, Chu CS, Spicer DA, Brusniak MY, Slagel J, Sun Z, Stevens J, Grimes B, Shteynberg D, Hoopmann MR, Blattmann P, Ratushny AV, Rinner O, Picotti P, Carapito C, Huang CY, Kapousouz M, Lam H, Tran T, Demir E, Aitchison JD, Sander C, Hood L, Aebersold R, Moritz RL. Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome, Cell, 2016, 166(3), 766-778. PMID: 27453469.
Maixner F, Krause-Kyora B, Turaev D, Herbig A, Hoopmann MR, Hallows JL, Kusebauch U, Vigl EE, Malfertheiner P, Megraud F, O´Sullivan N, Cipollini G, Coia V, Samadelli M, Engstrand L, Linz B, Moritz RL, Grimm R, Krause J, Nebel A, Moodley Y, Rattei T, Zink A, The 5,300-year-old Helicobacter pylori genome of the Iceman, Science, 2016, 351(6269), 162-165. PMID: 26744403.
Kusebauch U, Ortega C, Ollodart A, Rogers RS, Sherman DR, Moritz RL, Grundner C, Mycobacterium tuberculosis supports Protein Tyrosine Phosphorylation, Proc. Natl. Acad. Sci. USA, 2014, 111(25):9265-9270. PMID 24927537.
Picotti P, Clement-Ziza M, Lam H, Campbell DS, Schmidt A, Deutsch EW, Röst H, Sun Z, Rinner O, Reiter L, Shen Q, Michaelson JJ, Frei A, Alberti S, Kusebauch U, Wollscheid B, Moritz RL, Beyer A, Aebersold R, A complete mass spectrometric map for the analysis of the yeast proteome and its application to quantitative trait analysis, Nature, 2013, 494(7436), 266-70. PMID 23334424.