[{"id":136677,"date":"2024-12-09T11:12:08","date_gmt":"2024-12-09T19:12:08","guid":{"rendered":"https:\/\/isbscience.org\/?p=136677"},"modified":"2024-12-11T20:02:52","modified_gmt":"2024-12-12T04:02:52","slug":"2024-year-in-review","status":"publish","type":"post","link":"https:\/\/isbscience.org\/news\/2024\/12\/09\/2024-year-in-review\/","title":{"rendered":"2024 Year in Review"},"content":{"rendered":"<p>ISB reflects on 2024 with much to celebrate: groundbreaking research published in leading scientific journals, well-earned promotions, widespread media coverage, and more.<\/p>\n<p>Yet, the year was profoundly marked by the loss of our beloved colleague and friend, Dr. Ilya Shmulevich, who passed away in April at age 54 from complications of acute myeloid leukemia.<\/p>\n<blockquote><p>\u201cIlya\u2019s impact on his lab, fellow faculty, ISB as a whole, and all who had the pleasure of knowing him cannot be adequately expressed. He was an outstanding scientist, mentor, colleague, collaborator, and friend,\u201d said ISB President Dr. Jim Heath.<\/p><\/blockquote>\n<div id=\"attachment_136479\" style=\"width: 650px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-136479\" class=\"wp-image-136479 size-large\" src=\"https:\/\/isbscience.org\/wp-content\/uploads\/202311-Ilya-1024x683.jpg\" alt=\"Dr. Ilya Shmulevich\" width=\"640\" height=\"427\" srcset=\"https:\/\/isbscience.org\/wp-content\/uploads\/\/202311-Ilya-1024x683.jpg 1024w, https:\/\/isbscience.org\/wp-content\/uploads\/\/202311-Ilya-300x200.jpg 300w, https:\/\/isbscience.org\/wp-content\/uploads\/\/202311-Ilya-768x512.jpg 768w, https:\/\/isbscience.org\/wp-content\/uploads\/\/202311-Ilya-960x640.jpg 960w, https:\/\/isbscience.org\/wp-content\/uploads\/\/202311-Ilya-600x400.jpg 600w, https:\/\/isbscience.org\/wp-content\/uploads\/\/202311-Ilya.jpg 1200w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><p id=\"caption-attachment-136479\" class=\"wp-caption-text\">Dr. Ilya Shumlevich in front of his office door at ISB in November 2023. (Scott Eklund\/Redbox Photography)<\/p><\/div>\n<blockquote><p>\u201cHe led a life like no other, and we will never forget him,\u201d added ISB Co-founder and Professor Dr. Lee Hood.<\/p><\/blockquote>\n<p>In June, ISB hosted a celebration of life for Ilya\u2019s friends, colleagues, and family. In October, we honored his legacy with \u201cResonance,\u201d a scientific symposium celebrating his life and groundbreaking contributions to science.<\/p>\n<p>Dr. Shmulevich\u2019s memory and legacy will forever be a part of ISB.<\/p>\n<p><a id=\"top\"><\/a>Please read on for our year-in-review roundup highlighting our most important, interesting, and impactful highlights of 2024. You can scroll through, or click the links below on the section that interests you most.<\/p>\n<hr \/>\n<p style=\"text-align: center;\"><a href=\"#research\">Research<\/a>\u00a0 \u00a0|\u00a0 \u00a0<a href=\"#awards\">Awards &amp; Honors<\/a>\u00a0 \u00a0| \u00a0 <a href=\"#events\">Events<\/a>\u00a0 \u00a0| \u00a0 <a href=\"#media\">Media Coverage<\/a><\/p>\n<hr \/>\n<p><a id = \"research\"><\/a><br \/>\n&nbsp;<\/p>\n<h3><span style=\"color: #006eff;\">Research<\/span><\/h3>\n<p><b>Bowel Movement Frequency and Overall Health<br \/>\n<\/b><span style=\"font-weight: 400;\">Everybody poops, but not every day. Research out of the Gibbons Lab suggests bowel movement frequency\u00a0is linked to long-term health. The researchers examined the clinical, lifestyle, and multi-omic data\u00a0of more than 1,400 healthy adults. How often people poop, they found, can have a large influence on one\u2019s physiology and health. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/07\/16\/timing-is-everything-isb-study-finds-link-between-bowel-movement-frequency-and-overall-health\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><b>Microbiome-Informed Precision Nutrition<br \/>\n<\/b><span style=\"font-weight: 400;\">Short-chain fatty acids (SCFAs) are beneficial molecules created by the bacteria residing in our gut that are closely tied to improved host metabolism, lower systemic inflammation, better cardiovascular health, lower cancer risk, and more. However, SCFA profiles can vary widely between individuals consuming the same diet. Researchers in the Gibbons Lab have built a \u201cdigital twin\u201d of gut microbiome metabolism that can simulate personalized responses to diet by using gut microbiome sequencing data and information on dietary intake to constrain each individual-specific model. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/06\/24\/a-new-path-toward-microbiome-informed-precision-nutrition\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">, and watch a video with <\/span><b>Dr. Sean Gibbons <\/b><span style=\"font-weight: 400;\">and <\/span><b>Dr. Nick Quinn-Bohmann <\/b><span style=\"font-weight: 400;\">below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Predicting Personalized SCFA Production Profiles in the Human Gut\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/h6pHdbr2abw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p><b>Common Immune Response Protective Across Many Diseases<\/b><br \/>\n<span style=\"font-weight: 400;\">Combined, infection, autoimmunity and cancer account for four out of every 10 deaths worldwide, and represent major global health challenges. In a paper in the journal <em>Cell Reports<\/em>, Heath Lab researchers highlighted a novel discovery of how the human immune system works in common ways across diseases, and offer promising avenues for exploring multi-disease therapeutic strategies. <a href=\"https:\/\/isbscience.org\/news\/2024\/03\/04\/common-immune-response-protective-across-many-diseases\/\">Read our news story here<\/a>, and watch a video conversation between <strong>Daniel Chen<\/strong> and <strong>Dr. Jim Heath<\/strong> below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Common Immune Response Protective Across Many Diseases\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/TR9I2odzBCs?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p><b>AI\u2019s Potential and Pitfalls<br \/>\n<\/b><span style=\"font-weight: 400;\">ISB researchers have gained new insights into the strengths and limitations of using artificial intelligence (AI) to identify social determinants of health from electronic health records. Members of the Hadlock Lab, collaborating with Providence, leveraged large language models (LLM) developed from generative pre-trained transformers (GPT). The researchers highlighted the strengths of LLMs in uncovering social determinants of health but underscored the need for human oversight and improved data de-identification methods. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/11\/21\/isb-study-highlights-ais-potential-and-pitfalls-in-analyzing-health-data\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><b>How Glioblastoma Resists Treatment<br \/>\n<\/b><span style=\"font-weight: 400;\">Glioblastoma is one of the deadliest and most aggressive forms of primary brain cancer in adults and is known for its ability to resist treatment and to recur. Baliga Lab researchers have made breakthrough discoveries in understanding the mechanisms behind acquired resistance, focusing on a rare and stubborn group of cells within tumors called glioma stem-like cells. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/07\/09\/isb-researchers-identify-how-glioblastoma-resists-treatment-and-ways-to-prevent-it\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><b>Advancing Informal STEM Learning<br \/>\n<\/b><span style=\"font-weight: 400;\">An ISB-led study unveiled important insights and actionable protocols for providing equitable STEM experiences for high school students from historically marginalized communities. <\/span><b>Claudia Ludwig <\/b><span style=\"font-weight: 400;\">and colleagues demonstrated significant gains among high school students participating in in-person and remote informal STEM programs, ranging from 22 to 320 hours in length. Key factors contributing to this success include authentic research experiences, connections with STEM professionals, hands-on projects, and collaborative group work. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/03\/07\/new-research-unveils-effective-stem-program-models-for-high-school-students-from-historically-marginalized-communities\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">, and watch Ludwig discuss her work in the video below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Jim Heath Interviews Claudia McLaughlin Ludwig on Advancing Informal STEM Learning\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/iORqo58M7sk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p><b>Microbes Evolve to Spatially Divide and Conquer<br \/>\n<\/b><span style=\"font-weight: 400;\">Researchers in the Baliga Lab examined representative organisms of two classes of microbes whose interaction contributes to the conversion of more than 1 gigaton of carbon into methane every year. They showed that ecotypes of the same species can emerge over very short evolutionary timescales to specialize and collaborate with ecotypes of other species to significantly increase the productivity of ecologically important functions like methane production. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/09\/04\/how-microbes-evolve-to-spatially-divide-and-conquer-an-environment\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><b>Autoimmune Disease and Pregnancy<br \/>\n<\/b><span style=\"font-weight: 400;\">For many aspiring mothers with autoimmune diseases, pregnancy can be daunting and full of unknowns. In some cases, those suffering from specific autoimmune conditions have chosen to forego pregnancy altogether due to concerns about their disease treatments and adverse pregnancy outcomes. In a study in the journal <\/span><i><span style=\"font-weight: 400;\">Lancet eClinical Health<\/span><\/i><span style=\"font-weight: 400;\">, Hadlock Lab researchers showed nuanced pregnancy outcomes for pregnant individuals with autoimmune diseases. The findings reinforce that there isn\u2019t a one-size-fits-all approach, and provide important new avenues for further investigation. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/02\/01\/autoimmune-disease-and-pregnancy-isb-study-challenges-prevailing-wisdom-unveils-nuances\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">, and watch a video featuring <\/span><b>Dr. Jennifer Hadlock<\/b><span style=\"font-weight: 400;\"> below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Autoimmune Disease and Pregnancy\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/19qzFXIORMQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #002664;\"><a class=\"button\" style=\"color: #002664;\" href=\"#top\">Back to top \u2191<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><a id = \"awards\"><\/a><br \/>\n&nbsp;<\/p>\n<h3><\/h3>\n<h3><span style=\"color: #006eff;\">Awards and Honors<\/span><\/h3>\n<p><b>Dr. Sean Gibbons<\/b><span style=\"font-weight: 400;\"> and colleagues were awarded a 2024-2025 Amazon Web Services IMAGINE Grant for Nonprofits. The grant will support the Gibbons Lab\u2019s continued development of My Digital Gut. This online decision-support platform will help make microbiome-informed nutrition and healthcare personalized, predictive, and preventive. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/12\/03\/isb-named-winner-of-2024-2025-amazon-web-services-imagine-grant-for-nonprofits\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><b>Dr. Wei Wei<\/b><span style=\"font-weight: 400;\">, an accomplished cancer researcher with expertise in biotechnology and cancer systems biology, was promoted to ISB associate professor. \u201cI am deeply honored by this promotion, and I am excited to continue our efforts \u2013 harnessing systems biology thinking and approaches to push the boundaries of fundamental and translational cancer research,\u201d Wei said. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/07\/10\/dr-wei-wei-promoted-to-associate-professor\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><b>Dr. Sid Venkatesh <\/b><span style=\"font-weight: 400;\">is the co-first author of a paper in the journal <\/span><i><span style=\"font-weight: 400;\">Science<\/span><\/i><span style=\"font-weight: 400;\">. Following his 2019 work, where he co-led the development of a new class of nutritional interventions, microbiota-directed complementary foods (MDCFs), Venkatesh and Dr. Jiye Cheng (co-first author on the recent paper) identified a novel gut microbial enzyme that impacts satiety-related signaling pathways in undernourished children treated with MDCFs. Venkatesh made the discovery as a postdoctoral research associate in Dr. Jeffrey I. Gordon\u2019s laboratory at Washington University in St. Louis. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/11\/13\/sid-venkatesh-publishes-co-first-authored-paper-in-science\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><b>Faduma Hussein<\/b><span style=\"font-weight: 400;\"> joined the ISB Education team as the Public Health Ambassador Coordinator, becoming only the fourth AmeriCorps member to serve at ISB. Hussein plans to help high school students develop their systems thinking skills to improve the overall health of their communities. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/11\/13\/americorps-member-faduma-hussein-joins-isb-as-public-health-ambassador-coordinator\/\"><span style=\"font-weight: 400;\">Read our Q&amp;A with Faduma Hussein here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #002664;\"><a class=\"button\" style=\"color: #002664;\" href=\"#top\">Back to top \u2191<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><a id = \"events\"><\/a><br \/>\n&nbsp;<\/p>\n<h3><\/h3>\n<h3><span style=\"color: #006eff;\">Events<\/span><\/h3>\n<p>&nbsp;<\/p>\n<h3><\/h3>\n<h6><b>TOWN HALL SEATTLE<\/b><\/h6>\n<p><span style=\"font-weight: 400;\">ISB has had a long and successful partnership with Town Hall Seattle. In 2024, we co-produced a fun and informative event with Town Hall that brought together an award-winning Netflix director and her scientific advisor \u2013\u00a0our very own Sean Gibbons.\u00a0<\/span><\/p>\n<p><b>Hack Your Health: An Evening with Anjali Nayar and Dr. Sean Gibbons<br \/>\n<\/b><span style=\"font-weight: 400;\">The popular Netflix documentary \u201c<\/span><a href=\"https:\/\/www.netflix.com\/title\/81436688\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Hack Your Health: The Secrets of Your Gut<\/span><\/a><span style=\"font-weight: 400;\">\u201d was released in April. The film merged world-renowned gut microbiome experts, four individuals facing personal battles with gastrointestinal health, and a unique, effective visual method of \u201cshowing\u201d the gut microbiome in action, resulting in a scientifically accurate and ultimately understandable narrative accessible to all audiences. In June, ISB and Town Hall Seattle coordinated to put on a panel discussion with \u201cHack Your Health\u201d Director Anjali Nayar and <\/span><b>Sean Gibbons<\/b><span style=\"font-weight: 400;\">, who served as the scientific advisor on the documentary. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/07\/03\/hack-your-health-an-evening-with-anjali-nayar-and-dr-sean-gibbons\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">, and watch the video of the presentation below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Unlocking the Mysteries of Your Gut\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/mLbkC9NiYYs?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<h6><b>RESEARCH ROUNDTABLE<\/b><\/h6>\n<p><span style=\"font-weight: 400;\">We host the Research Roundtable virtual series to keep you updated on the novel research happening at ISB. In 2024, we hosted three interesting and varied roundtables.\u00a0<\/span><\/p>\n<p><b>Precision Cancer Care Faster Than Ever<br \/>\n<\/b><b>Dr. Wei Wei<\/b><span style=\"font-weight: 400;\"> and his colleagues have developed a promising new companion diagnostic tool called MetaboCore to help physicians quickly select the most effective systemic therapy to get the right drug to the right cancer patient at the right time. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/11\/27\/isb-developed-metabocore-offers-precision-cancer-care-faster-than-ever\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">, and watch the video below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Precision Cancer Care Faster Than Ever\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/UtTdf18q9sM?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p><b>A Digital Twin for Your Gut<br \/>\n<\/b><b>Dr. Sean Gibbons<\/b><span style=\"font-weight: 400;\"> is creating a new precision nutrition platform called My Digital Gut that leverages the gut microbiome to make nutrition and healthcare personalized, predictive, and preventive. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/05\/03\/my-digital-gut-making-nutrition-and-healthcare-personalized-predictive-and-preventive\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">, and watch the video below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"My Digital Gut: Making Nutrition and Healthcare Personalized, Predictive, and Preventive\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/7pbSOLsIX_M?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p><b>The Future of Cancer Immunotherapy<br \/>\n<\/b><span style=\"font-weight: 400;\">ISB President <\/span><b>Dr. Jim Heath<\/b><span style=\"font-weight: 400;\"> detailed <\/span><span style=\"font-weight: 400;\">a breakthrough discovery from his lab that changes how we understand T cells. The discovery has implications for how we can better engineer custom immune responses to fight disease. Heath discussed how different disease-fighting functions of different T cells are determined by the genetically encoded T-cell receptor sequences that are unique to those cells.<\/span> <a href=\"https:\/\/isbscience.org\/news\/2024\/02\/02\/breakthrough-t-cell-discovery-has-huge-potential-for-engineering-custom-immune-responses\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">, and watch the video below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Dr. Jim Heath on the Future of Cancer Immunotherapy\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/VU9Z6vTnyy8?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<h6><b>COURSES AND SYMPOSIA<\/b><\/h6>\n<p><span style=\"font-weight: 400;\">Our scientific expertise gives us the unique opportunity to share knowledge with the broader research community, including graduate students, postdoctoral fellows, research scientists, industry scientists, and more.\u00a0<\/span><\/p>\n<p><b>A Gut Feeling: Microbes and Their Impacts on Our Minds<br \/>\n<\/b><span style=\"font-weight: 400;\">There has been an explosion of research into the two-way communication between the gut microbiota and the brain, which has helped us to understand complex behavioral and neurophysiological phenotypes in many animal species. In 2024, ISB hosted a virtual microbiome series dedicated to exploring the gut-brain axis. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/10\/28\/a-gut-feeling-microbes-and-their-impacts-on-our-minds\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">, and watch the video below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"2024 Microbiome Course \u2013 Day 1\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/bR7AFbLiNGo?list=PLOojCp_ZOt2deUjJb4HmsPmRhGhtAqIrW\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p><b>Resonance: Celebrating Ilya Shmulevich\u2019s Life and Scientific Contributions<br \/>\n<\/b><span style=\"font-weight: 400;\">ISB hosted a full-day symposium featuring speakers whose research resonates with and has been profoundly influenced by Dr. Ilya Shmulevich\u2019s work. Session topics included digital health, modeling and theory, and cancer genomics, reflecting the broad impact of his scientific legacy. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/10\/12\/resonance-celebrating-professor-ilya-shmulevichs-life-and-scientific-contributions\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">, and watch the video below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Dr. Jim Heath\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/wU9K09LrCaE?list=PLOojCp_ZOt2f2s6vq2jRK3oRBrBru5d01\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p><b>Systems Biology of Aging Virtual Workshop<br \/>\n<\/b><span style=\"font-weight: 400;\">As the global population ages, understanding the mechanisms of aging has become an essential area of research with profound implications for healthcare, policy, and quality of life. In May, ISB hosted a virtual, free, hands-on workshop that provided practical tools for performing multi-omic systems biology analyses. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/05\/15\/systems-biology-of-aging-virtual-workshop\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">, and watch the video below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Systems Biology of Aging Workshop\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/4SNOqbkb7B0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p><b>Spatial Multi-Omics for Cancer Systems Biology<br \/>\n<\/b><span style=\"font-weight: 400;\">In February, ISB hosted a free one-day Spatial Multi-Omics for Cancer Systems Biology virtual workshop. The event consisted of sessions on four topics: experimental methods, computational algorithms, applications of spatial multi-omics and a practical methods tutorial. <\/span><a href=\"https:\/\/isbscience.org\/news\/2024\/02\/13\/spatial-multi-omics-for-cancer-systems-biology\/\"><span style=\"font-weight: 400;\">Read our news story here<\/span><\/a><span style=\"font-weight: 400;\">, and watch the video playlist below.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Opening Remarks &amp; Session One: Intro | Jim Heath, PhD\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/kNCppO8UvYk?list=PLOojCp_ZOt2fqOg0esXbuPsX5eXz2KypV\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #002664;\"><a class=\"button\" style=\"color: #002664;\" href=\"#top\">Back to top \u2191<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><a id = \"media\"><\/a><br \/>\n&nbsp;<\/p>\n<h3><\/h3>\n<h3><span style=\"color: #006eff;\">Media Coverage<\/span><\/h3>\n<p><b>How often you poop can affect your health well beyond the gut, study suggests<br \/>\n<\/b><span style=\"font-weight: 400;\">Dr. Sean Gibbons was interviewed for this <\/span><a href=\"https:\/\/www.nbcnews.com\/health\/health-news\/often-poop-can-affect-health-well-gut-study-suggests-rcna161920\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">NBC News story<\/span><\/a><span style=\"font-weight: 400;\"> focusing on their research that found a link between bowel movement frequency and overall health.\u00a0<\/span><\/p>\n<p><b>Here\u2019s what your pooping frequency says about your health<br \/>\n<\/b><span style=\"font-weight: 400;\">Science reporter Torah Kachur interviewed Dr. Sean Gibbons for this <\/span><a href=\"https:\/\/www.cbc.ca\/listen\/live-radio\/1-81-airplay\/clip\/16082489-a-sensitive-story\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">CBC Radio report<\/span><\/a><span style=\"font-weight: 400;\"> showing that the <\/span><span style=\"font-weight: 400;\">frequency of your bowel movements can tell you a lot about your health.<\/span><\/p>\n<p><b>Personalizing nutrition based on the gut microbiome<br \/>\n<\/b><span style=\"font-weight: 400;\">Metabolically speaking, not everyone responds the same to the same foods. Dr. Sean Gibbons was interviewed for this <\/span><a href=\"https:\/\/www.drugdiscoverynews.com\/personalizing-nutrition-based-on-the-gut-microbiome-16011\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Drug Discovery News<\/span><\/a><span style=\"font-weight: 400;\"> story highlighting Gibbons Lab research examining if they could use a model they created to design personalized interventions to optimize the production of short chain fatty acids.\u00a0\u00a0<\/span><\/p>\n<p><b>Common immune response is found to be protective across many diseases<br \/>\n<\/b><span style=\"font-weight: 400;\">This <\/span><a href=\"https:\/\/medicalxpress.com\/news\/2024-03-common-immune-response-diseases.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Medical Xpress story<\/span><\/a><span style=\"font-weight: 400;\"> describes how Heath Lab researchers offer promising avenues for exploring multi-disease therapeutic strategies.<\/span><\/p>\n<p><b>Reverse Brain Aging: Tools and Techniques You Need to Know with Dr. Leroy Hood<br \/>\n<\/b><span style=\"font-weight: 400;\">Dr. Lee Hood was interviewed by Dr. Mark Hyman on the <\/span><a href=\"https:\/\/drhyman.com\/blogs\/content\/podcast-ep917\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Doctor\u2019s Farmacy Podcast<\/span><\/a><span style=\"font-weight: 400;\"> and talked about the tools and techniques to reverse brain aging.\u00a0<\/span><\/p>\n<p><b>Personalized Healthcare is More Effective and it&#8217;s Already Here<br \/>\n<\/b><span style=\"font-weight: 400;\">Dr. Lee Hood spoke with Drs. Grant Cooper and Zinovy Meyler for a <\/span><a href=\"https:\/\/performanceinitiativepodcast.buzzsprout.com\/2293882\/15188155-26-personalized-healthcare-is-more-effective-and-it-s-already-here-lee-hood-md-phd\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Performance Initiative Podcast interview<\/span><\/a><span style=\"font-weight: 400;\"> that spanned the transformative role of AI in healthcare, and much more.\u00a0<\/span><\/p>\n<p><b>AI Assistance for Planning Cancer Treatment<br \/>\n<\/b><span style=\"font-weight: 400;\">Dr. Ilya Shmulevich, who passed away in April 2024, was interviewed for this <\/span><a href=\"https:\/\/www.nature.com\/articles\/d41586-024-01431-8\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Nature story<\/span><\/a><span style=\"font-weight: 400;\"> and talked about his lab\u2019s digital twin project.<\/span><\/p>\n<p><b>Link Between Inflammatory Disease, Adverse Pregnancy Outcomes Varies<br \/>\n<\/b><span style=\"font-weight: 400;\">This <\/span><a href=\"https:\/\/www.healthday.com\/healthpro-news\/pregnancy\/link-between-inflammatory-disease-adverse-pregnancy-outcomes-varies\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">HealthDay story<\/span><\/a><span style=\"font-weight: 400;\"> details research by Dr. Jennifer Hadlock\u2019s lab showing how the association between immune-mediated inflammatory diseases (IMIDs) and adverse pregnancy outcomes varies with the nature of IMID and the presence of comorbidities.<\/span><\/p>\n<p><b>Comorbidities Weigh Heavily in IMID Pregnancy Outcomes<br \/>\n<\/b><a href=\"https:\/\/www.medscape.com\/viewarticle\/comorbidities-weigh-heavily-immune-mediated-inflammatory-2024a10002o8?src=rss&amp;form=fpf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Medscape interviewed<\/span><\/a><span style=\"font-weight: 400;\"> Dr. Jennifer Hadlock about comorbidities playing a major role in poor birth outcomes, such as preterm birth and low birth weight, in patients with specific autoimmune diseases.<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #002664;\"><a class=\"button\" style=\"color: #002664;\" href=\"#top\">Back to top \u2191<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Reflecting on the past year, ISB has a lot to celebrate: groundbreaking research published in leading scientific journals, well-earned promotions, widespread media coverage, and more. Enjoy our year-in-review roundup highlighting some of the important, interesting, and impactful highlights of 2024.<\/p>\n","protected":false},"author":4,"featured_media":136688,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[65,14],"tags":[26,179,480,1589,36],"class_list":["post-136677","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-events","category-people","tag-awards","tag-events-2","tag-honors","tag-media-coverage","tag-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.8 (Yoast SEO v21.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>2024 Year in Review &#183; Institute for Systems Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/isbscience.org\/news\/2024\/12\/09\/2024-year-in-review\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"2024 Year in Review\" \/>\n<meta property=\"og:description\" content=\"Reflecting on the past year, ISB has a lot to celebrate: groundbreaking research published in leading scientific journals, well-earned promotions, widespread media coverage, and more. Enjoy our year-in-review roundup highlighting some of the important, interesting, and impactful highlights of 2024.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/isbscience.org\/news\/2024\/12\/09\/2024-year-in-review\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Systems Biology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/isbsci\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-09T19:12:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-12T04:02:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/isbscience.org\/wp-content\/uploads\/Year_in_Review_Video-Collage2024.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Allison Kudla\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@isbsci\" \/>\n<meta name=\"twitter:site\" content=\"@isbsci\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Allison Kudla\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"10 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/isbscience.org\/news\/2024\/12\/09\/2024-year-in-review\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/isbscience.org\/news\/2024\/12\/09\/2024-year-in-review\/\"},\"author\":{\"name\":\"Allison Kudla\",\"@id\":\"https:\/\/isbscience.org\/#\/schema\/person\/3aa7419408d078363ae18912ae24014e\"},\"headline\":\"2024 Year in Review\",\"datePublished\":\"2024-12-09T19:12:08+00:00\",\"dateModified\":\"2024-12-12T04:02:52+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/isbscience.org\/news\/2024\/12\/09\/2024-year-in-review\/\"},\"wordCount\":2254,\"publisher\":{\"@id\":\"https:\/\/isbscience.org\/#organization\"},\"keywords\":[\"Awards\",\"events\",\"honors\",\"media coverage\",\"research\"],\"articleSection\":[\"Events\",\"People\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/isbscience.org\/news\/2024\/12\/09\/2024-year-in-review\/\",\"url\":\"https:\/\/isbscience.org\/news\/2024\/12\/09\/2024-year-in-review\/\",\"name\":\"2024 Year in Review &#183; 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The grant will support ISB\u2019s continued development of My Digital Gut, an online decision-support platform that will help make microbiome-informed nutrition and healthcare personalized, predictive, and preventive.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Now in its seventh year, the AWS IMAGINE Grant provides vital resources to nonprofit organizations looking to deploy cloud technology as a central tool to achieve mission goals. As part of the program, AWS seeks proposals for big ideas on how to leverage cloud technology in new and innovative ways to accelerate impact in local and global communities.<\/span><span class=\"s1\">\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">ISB was named a winner in the <i>Momentum to Modernize <\/i>category, which recognizes foundational technology projects. ISB will receive $50,000 in unrestricted funding, $5,000 in AWS Promotional Credits, and project implementation support. Proposals were judged on several factors including the innovative and unique nature of the project, impact on mission-critical goals, and clearly defined outcomes and milestones.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">My Digital Gut is designed to be an essential tool that enables physicians and their patients to identify life-changing precision interventions. My Digital Gut was conceived in the lab of <a href=\"https:\/\/isbscience.org\/bio\/sean-gibbons\/\">ISB Associate Professor Sean Gibbons, PhD<\/a>. Following initial validation of their technology, Gibbons and his colleagues are planning a clinical trial to test whether or not personalized interventions are better at improving cardiometabolic health than placebo or standard-of-care nutritional interventions. My Digital Gut will serve as a decision support system for researchers and clinicians to deploy personalized, microbiome-informed nutritional interventions in these clinical trials.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Gibbons envisions individuals using My Digital Gut as a personalized health assistant, where a person\u2019s data will be uploaded to the My Digital Gut tool. Then, the individual will be shown their unique \u201cdigital twin\u201d \u2013 an avatar representing the metabolic capacity of their microbiota in the context of a given dietary intake. Potential applications of this interface are to digitally test the effects of varying diets \u2013\u00a0Mediterranean vs. Atkins, for example \u2013 or the effects of different prebiotic and probiotic interventions on the production of health-relevant microbial metabolites.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">\u201cWe are honored to receive this generous award from AWS, which will help us to deploy our My Digital Gut prototype and enable the next phase of validation work in human trials,\u201d Gibbons said.<\/span><span class=\"s1\">\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">&#8220;At AWS, we&#8217;re inspired by the nonprofit sector&#8217;s unwavering commitment to preserving the dignity and health of people and our planet,&#8221; said Allyson Fryhoff, managing director of nonprofit and nonprofit health at AWS. &#8220;Our Imagine Grant winners are pioneering groundbreaking, technology-driven approaches that will amplify their mission impact and build a more equitable and compassionate world. We are thrilled to work alongside these organizations, helping them leverage the transformative capabilities of the AWS Cloud to bring these projects to life.\u201d<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">Since the launch of the IMAGINE Grant program in 2018, AWS has awarded over $14 million in unrestricted funds, AWS Promotional Credits, and expert technical guidance to over 130 nonprofit organizations in support of their technology-driven goals. Previous winners are currently using AWS services to tackle critical challenges such as<a href=\"https:\/\/aws.amazon.com\/solutions\/case-studies\/houston-food-bank-podcast-customer-story\/?podcast-list-wide.sort-by=item.additionalFields.EpisodeNum&amp;podcast-list-wide.sort-order=desc\"> <span class=\"s3\">eliminating barriers to food security<\/span><\/a>,<a href=\"https:\/\/aws.amazon.com\/blogs\/publicsector\/jacaranda-health-advances-maternal-infant-health-across-kenya-beyond-aws\/\" target=\"_blank\" rel=\"noopener\"> <span class=\"s3\">improving maternal health outcomes<\/span><\/a>, helping millions access clean and safe drinking water globally, tackling rare disease research, and more.<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">Over 85,000 nonprofit organizations worldwide use AWS to increase their impact and advance mission goals. Through<a href=\"https:\/\/aws.amazon.com\/government-education\/nonprofits\/\"> <span class=\"s3\">multiple programs<\/span><\/a> tailored specifically to the nonprofit community, AWS enables nonprofits of all sizes to overcome barriers to technology adoption, while enhancing the scale, performance, and capabilities of mission operations.<\/span><\/p>\n<p>Learn more about My Digital Gut by watching the video below.<\/p>\n<p><iframe loading=\"lazy\" title=\"My Digital Gut: Making Nutrition and Healthcare Personalized, Predictive, and Preventive\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/7pbSOLsIX_M?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ISB has been selected as a winner of the 2024 Amazon Web Services (AWS) IMAGINE Grant. The grant will support ISB\u2019s continued development of My Digital Gut, an online decision-support platform that will help make microbiome-informed nutrition and healthcare personalized, predictive, and preventive.\u00a0<\/p>\n","protected":false},"author":49,"featured_media":136669,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1607,846],"tags":[1248,1249,581,145,1600],"class_list":["post-136668","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gibbons-lab","category-press-release","tag-dr-sean-gibbons","tag-gibbons-lab","tag-gut-microbiome","tag-microbiome","tag-my-digital-gut"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.8 (Yoast SEO v21.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>ISB Named Winner of 2024-2025 Amazon Web Services IMAGINE Grant for Nonprofits &#183; Institute for Systems Biology<\/title>\n<meta name=\"description\" content=\"ISB was selected as a winner of the 2024 Amazon Web Services (AWS) IMAGINE Grant, which will support continued development of My Digital Gut.\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/isbscience.org\/news\/2024\/12\/03\/isb-named-winner-of-2024-2025-amazon-web-services-imagine-grant-for-nonprofits\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ISB Named Winner of 2024-2025 Amazon Web Services IMAGINE Grant for Nonprofits\" \/>\n<meta property=\"og:description\" content=\"ISB was selected as a winner of the 2024 Amazon Web Services (AWS) IMAGINE Grant, which will support continued development of My Digital Gut.\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/isbscience.org\/news\/2024\/12\/03\/isb-named-winner-of-2024-2025-amazon-web-services-imagine-grant-for-nonprofits\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Systems Biology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/isbsci\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-03T19:29:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/isbscience.org\/wp-content\/uploads\/MDG-ISB-social.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Joe Myxter\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@isbsci\" \/>\n<meta name=\"twitter:site\" content=\"@isbsci\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Joe Myxter\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/isbscience.org\/news\/2024\/12\/03\/isb-named-winner-of-2024-2025-amazon-web-services-imagine-grant-for-nonprofits\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/isbscience.org\/news\/2024\/12\/03\/isb-named-winner-of-2024-2025-amazon-web-services-imagine-grant-for-nonprofits\/\"},\"author\":{\"name\":\"Joe Myxter\",\"@id\":\"https:\/\/isbscience.org\/#\/schema\/person\/c2a147fbd9132363d18318b6bdabcc8d\"},\"headline\":\"ISB Named Winner of 2024-2025 Amazon Web Services IMAGINE Grant for Nonprofits\",\"datePublished\":\"2024-12-03T19:29:38+00:00\",\"dateModified\":\"2024-12-03T19:29:38+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/isbscience.org\/news\/2024\/12\/03\/isb-named-winner-of-2024-2025-amazon-web-services-imagine-grant-for-nonprofits\/\"},\"wordCount\":645,\"publisher\":{\"@id\":\"https:\/\/isbscience.org\/#organization\"},\"keywords\":[\"Dr. Sean Gibbons\",\"Gibbons Lab\",\"gut microbiome\",\"microbiome\",\"My Digital Gut\"],\"articleSection\":[\"Gibbons Lab\",\"Press Release\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/isbscience.org\/news\/2024\/12\/03\/isb-named-winner-of-2024-2025-amazon-web-services-imagine-grant-for-nonprofits\/\",\"url\":\"https:\/\/isbscience.org\/news\/2024\/12\/03\/isb-named-winner-of-2024-2025-amazon-web-services-imagine-grant-for-nonprofits\/\",\"name\":\"ISB Named Winner of 2024-2025 Amazon Web Services IMAGINE Grant for Nonprofits &#183; 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However, cancer is difficult to treat in part because it isn\u2019t just one disease \u2013\u00a0every cancer is unique. Even if two people have the same type of cancer in the same organ, their tumors are different.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">And other important variables make precision cancer treatment challenging.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">There is the sheer number of cancer drugs on the market. In the past four years alone, more than 250 oncology drugs have been approved, bringing the total number to more than 600.<\/span><\/p>\n<blockquote>\n<p class=\"p1\"><span class=\"s1\">\u201cThis is the best of times \u2013 doctors now have more options to treat patients \u2013 but it is also the worst of times because an overwhelming number of options makes treatment decisions incredibly complex,\u201d said <a href=\"https:\/\/isbscience.org\/bio\/wei-wei\/\"><span class=\"s2\">ISB Associate Professor Dr. Wei Wei<\/span><\/a> during an ISB Research Roundtable presentation.<\/span><\/p>\n<\/blockquote>\n<p class=\"p1\"><span class=\"s1\">In metastatic colorectal cancer patients, for example, there are two first-line chemotherapy options, each with roughly a 50 percent response rate. This means half of patients won\u2019t respond to one of the drugs. Oncologists \u201care rolling the dice,\u201d Wei said. And if the tumor doesn\u2019t respond within three to six months, patients are switched to the other drug. \u201cThis trial-and-error approach means many patients have to endure unnecessary toxicity, costs, and delay in seeing an effective treatment.\u201d<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">There are also limitations in how tumor specimens are studied. Currently, tumor samples are taken from patients via needle biopsy. However, the amount of material is tiny, and traditional methods of augmenting the tumor material compromise the original tumor microenvironment, which is vital for a genuine drug response evaluation.\u00a0<\/span><\/p>\n<blockquote>\n<p class=\"p1\"><span class=\"s1\">\u201cThis is why so many drugs that give us hope in animal studies lead to heartbreak when they fail in human trials. Without the original tumor microenvironment, we lose the context that makes the drug response real,\u201d Wei said.<\/span><\/p>\n<\/blockquote>\n<p class=\"p1\"><span class=\"s1\"><b>Enter MetaboCore<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Wei and his colleagues have developed a promising new companion diagnostic tool called MetaboCore to help physicians quickly select the most effective systemic therapy for each cancer patient.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">MetaboCore uses microdissection to cut biopsied tumor samples into small pieces called discoids. Wei can generate hundreds of discoids \u2013 each about the size of a grain of sugar \u2013 from one diagnostic needle core.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Importantly, the discoids maintain an intact local tumor microenvironment during drug treatment allowing researchers to capture the most authentic drug response profile of each patient tumor.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">You can learn more about MetaboCore by <a href=\"https:\/\/www.youtube.com\/watch?v=UtTdf18q9sM&amp;t=1608s\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">watching Wei\u2019s presentation here<\/span><\/a> or playing the video at the top of this page.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>About Research Roundtable<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">ISB hosts several Research Roundtable conversations each year featuring our leading scientists discussing their latest research.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">These free virtual events are designed for a general audience and provide an environment to ask questions directly to our ISB researchers.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Past Research Roundtable topics include the human gut microbiome, breakthroughs in cancer immunotherapy, complex bacterial communities, long COVID, COVID\u2019s impact on pregnancy, Alzheimer\u2019s disease, finding drugs to treat tuberculosis, and more. You can explore all past Research Roundtable talks and our other events <a href=\"https:\/\/isbscience.org\/events\/\"><span class=\"s2\">here<\/span><\/a>.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ISB Associate Professor Dr. Wei Wei and his colleagues have developed a promising new companion diagnostic tool called MetaboCore to help physicians quickly select the most effective systemic therapy for each cancer patient.\u00a0<\/p>\n","protected":false},"author":49,"featured_media":136658,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[65,77],"tags":[148,807,1614,638,1259,1613,1615,1329],"class_list":["post-136657","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-events","category-video-isb-news","tag-cancer","tag-cancer-diagnostics","tag-cancer-therapy","tag-cancer-treatment","tag-dr-wei-wei","tag-metaboc-ore","tag-tumor-microenvironment","tag-wei-lab"],"acf":[],"yoast_head":"<!-- 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content=\"ISB&#039;s MetaboCore is a diagnostic tool that can help physicians quickly select the most effective systemic therapy for each cancer patient.\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/isbscience.org\/news\/2024\/11\/27\/isb-developed-metabocore-offers-precision-cancer-care-faster-than-ever\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Systems Biology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/isbsci\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-27T19:44:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-02T14:55:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/isbscience.org\/wp-content\/uploads\/Screenshot-2024-11-25-at-3.30.13\u202fPM.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1141\" \/>\n\t<meta property=\"og:image:height\" content=\"596\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta 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Biology"},"image":{"@id":"https:\/\/isbscience.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/isbsci","https:\/\/twitter.com\/isbsci","https:\/\/www.instagram.com\/isbsci","https:\/\/www.linkedin.com\/company\/institute-for-systems-biology","https:\/\/www.youtube.com\/user\/ISBSystemsBiology"]},{"@type":"Person","@id":"https:\/\/isbscience.org\/#\/schema\/person\/c2a147fbd9132363d18318b6bdabcc8d","name":"Joe Myxter","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/isbscience.org\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/2fe84cf0d44c1793865a76029b00cbac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/2fe84cf0d44c1793865a76029b00cbac?s=96&d=mm&r=g","caption":"Joe 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School Year ISB Education Highlights"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">Each month throughout the 2024-2025 academic year, we will highlight some of the top projects the ISB Education team is working on.<\/span><\/p>\n<h3>November<\/h3>\n<div id=\"attachment_136656\" style=\"width: 2570px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-136656\" class=\"wp-image-136656 size-full\" src=\"https:\/\/isbscience.org\/wp-content\/uploads\/IMG_3831-scaled.jpg\" alt=\"Dr. Phil Bell and Dr. Deb Morrison\" width=\"2560\" height=\"1920\" srcset=\"https:\/\/isbscience.org\/wp-content\/uploads\/\/IMG_3831-scaled.jpg 2560w, https:\/\/isbscience.org\/wp-content\/uploads\/\/IMG_3831-300x225.jpg 300w, https:\/\/isbscience.org\/wp-content\/uploads\/\/IMG_3831-1024x768.jpg 1024w, https:\/\/isbscience.org\/wp-content\/uploads\/\/IMG_3831-768x576.jpg 768w, https:\/\/isbscience.org\/wp-content\/uploads\/\/IMG_3831-1536x1152.jpg 1536w, https:\/\/isbscience.org\/wp-content\/uploads\/\/IMG_3831-2048x1536.jpg 2048w, https:\/\/isbscience.org\/wp-content\/uploads\/\/IMG_3831-1600x1200.jpg 1600w, https:\/\/isbscience.org\/wp-content\/uploads\/\/IMG_3831-960x720.jpg 960w, https:\/\/isbscience.org\/wp-content\/uploads\/\/IMG_3831-600x450.jpg 600w, https:\/\/isbscience.org\/wp-content\/uploads\/\/IMG_3831-1800x1350.jpg 1800w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><p id=\"caption-attachment-136656\" class=\"wp-caption-text\">Dr. Phil Bell and Dr. Deb Morrison were this year&#8217;s recipients of the Valerie Logan Leadership in Science Education Award.<\/p><\/div>\n<p class=\"p1\"><span class=\"s1\"><b>Ignite STEM! <\/b><\/span><span class=\"s2\"><b>Thank you to all the friends of ISB Education\u00a0\u00a0<\/b><\/span><\/p>\n<p class=\"p3\"><span class=\"s2\">On November 13, ISB held the annual <b>Ignite STEM<\/b> event to celebrate our education program impacts. At the heart of this evening is the Valerie Logan Leadership in Science Education award. The two awardees for this 11th year are Dr. Phil Bell and Dr. Deb Morrison, honored for their leadership in science ed to the College of Education and for their game-changing set of open-source<\/span><span class=\"s3\"> <a href=\"https:\/\/stemteachingtools.org\/\" target=\"_blank\" rel=\"noopener\"><span class=\"s4\">STEM Teaching Tools<\/span><\/a><\/span><span class=\"s5\">.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s2\">We appreciate your help making <b>Ignite STEM<\/b> a success \u2013 we&#8217;ve raised over $50,000 to support programs with students and educators this year.<\/span><\/p>\n<p class=\"p1\"><span class=\"s5\">S<\/span><span class=\"s2\">ee a <a href=\"https:\/\/www.flickr.com\/photos\/90930918@N08\/albums\/72177720321955599\/with\/54140377121\" target=\"_blank\" rel=\"noopener\"><span class=\"s6\">collection of photos from the event here<\/span><\/a>, and <a href=\"https:\/\/youtu.be\/XfL3r3PoJus\" target=\"_blank\" rel=\"noopener\"><span class=\"s6\">watch this video<\/span><\/a> of a moving recollection and tribute of a former ISB high school intern, who is now a graduate student working toward her PhD at UC Berkeley.<\/span><\/p>\n<p class=\"p3\"><span class=\"s2\"><b>Next-Gen Bio Learning Network \u2013 bringing ISB science to undergrad students<\/b><\/span><\/p>\n<p class=\"p3\"><span class=\"s2\">This month, the community college faculty dove deeper into their work for the year when they met with ISB faculty member <b>Dr. Jennifer Hadlock<\/b>. These biology faculty discussed a variety of topics with Jenn \u2013 a highlight was building a vision for course materials to support community college students to better understand how our personal health data is and isn\u2019t protected.\u00a0<\/span><\/p>\n<p class=\"p3\"><span class=\"s2\">The group will continue to partner with scientists throughout the year to continue to consider how the volume, velocity, and variety of biological data should be impacting our undergraduate learners.\u00a0<\/span><\/p>\n<p class=\"p3\"><span class=\"s2\"><b>LEADS completes its 5th cohort<\/b><\/span><\/p>\n<p class=\"p3\"><span class=\"s2\"><b>Leadership Empowerment And Development in STEM<\/b> (LEADS) 17 \u201cSystems Thinkers in STEM\u201d Ambassadors just completed their program as the 5th cohort of LEADS. This cohort was a hybrid model with four virtual sessions over Zoom and one in-person day onsite at ISB. The ambassadors truly enjoyed exploring STEM careers and various leadership roles and styles throughout the 12-hour program.\u00a0<\/span><\/p>\n<p class=\"p3\"><span class=\"s2\">A HUGE thank you to the ISB speakers who joined us during this cohort, <b>Monica Orellana<\/b>, <b>Samantha Peikos<\/b>, <b>Jake Valenzuela<\/b>, <b>Claudia Ludwig<\/b>, <b>Anna Kuchina<\/b> and <b>Alice Kane<\/b>.\u00a0<\/span><\/p>\n<p class=\"p3\"><span class=\"s2\">In total, 74 students have completed the LEADS program since its 2022 onset. To learn more about the LEADS program and various other Systems Education Experiences, check out our webpage <a href=\"https:\/\/see.isbscience.org\/resources\/for-students\/leads\/\" target=\"_blank\" rel=\"noopener\"><span class=\"s6\">here.<\/span><\/a><\/span><\/p>\n<h3>October<\/h3>\n<p class=\"p2\"><strong><span class=\"s1\">Welcome aboard: We have expanded our team<\/span><\/strong><\/p>\n<div id=\"attachment_136634\" style=\"width: 1210px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-136634\" class=\"wp-image-136634 size-full\" src=\"https:\/\/isbscience.org\/wp-content\/uploads\/new-edu-team-members.jpg\" alt=\"\" width=\"1200\" height=\"681\" srcset=\"https:\/\/isbscience.org\/wp-content\/uploads\/\/new-edu-team-members.jpg 1200w, https:\/\/isbscience.org\/wp-content\/uploads\/\/new-edu-team-members-300x170.jpg 300w, https:\/\/isbscience.org\/wp-content\/uploads\/\/new-edu-team-members-1024x581.jpg 1024w, https:\/\/isbscience.org\/wp-content\/uploads\/\/new-edu-team-members-768x436.jpg 768w, https:\/\/isbscience.org\/wp-content\/uploads\/\/new-edu-team-members-960x545.jpg 960w, https:\/\/isbscience.org\/wp-content\/uploads\/\/new-edu-team-members-600x341.jpg 600w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><p id=\"caption-attachment-136634\" class=\"wp-caption-text\">Faduma Hussein (left) is the newest AmeriCorps member to join ISB. Ethan Brown (right) joins ISB as an Education Assistant thanks to a Dean Witter Foundation grant.<\/p><\/div>\n<p class=\"p2\"><span class=\"s1\"><b>Faduma Hussein<\/b> recently joined ISB as a Public Health Ambassador Coordinator, and is the fourth AmeriCorps Member to work with our team. <a href=\"https:\/\/isbscience.org\/news\/2024\/11\/13\/americorps-member-faduma-hussein-joins-isb-as-public-health-ambassador-coordinator\/\">In this Q&amp;A<\/a>, Faduma shares what drew her to ISB, what she hopes to accomplish over the next year, and more. Faduma joins <b>Sarah Clemente<\/b>, who is now on her second AmeriCorps service term this year.\u00a0<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\"><b>Ethan Brown<\/b> returns to ISB to join our team as an Education Assistant thanks to a grant from the Dean Witter Foundation. <a href=\"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2018\/ethan-brown\/\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">Ethan was a 2018 high school intern<\/span><\/a> who helped us launch our <a href=\"https:\/\/see.isbscience.org\/modules\/systems-medicine\/\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">Systems Medicine education initiative<\/span><\/a>. We are thrilled to have him return with his advanced skills to further expand the reach and impact of the Systems Medicine 180-hour course.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Puget Sound LASER Alliance is a science leadership network to support all the school systems in Pierce and King Counties. This partnership is growing to deepen our impacts; <b>\u00a0Kirk Robbins<\/b> (science education consultant) and <b>Drs. Anastasia Sanchez<\/b> and <b>Kevin Ikeda<\/b> (Puget Sound Educational Service District) are now joining <b>John Leitzinger<\/b> and ISB Education to collaboratively lead this regional effort.<\/span><\/p>\n<p class=\"p2\"><strong><span class=\"s1\">Our programs for the 2024\/25 school year<\/span><\/strong><\/p>\n<p class=\"p2\"><span class=\"s1\">We are innovating a new format for \u201cSystems Are Everywhere!\u201d \u2013\u00a0 one of our popular ClimeTime workshops. The new format uses the Canvas platform, enabling teachers to learn online at their own pace over a four-week series. Teachers try out new strategies and concepts with their students in small steps throughout the series, with coaching from the ISB team and fellow participants.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Our partnership with Central Kitsap School District has entered its third year, and is off to a fast start. Five workshops in a 20-part series are completed, involving all the high school science teachers in the school system. Teachers collaboratively work on strategies targeted at enabling every student to do the \u201cfiguring out\u201d of phenomena, so students can uncover and \u201cdiscover\u201d\u00a0 key science concepts.\u00a0<\/span><\/p>\n<p class=\"p2\"><strong><span class=\"s1\">Presenting our work: Washington Science Teachers Association conference<\/span><\/strong><\/p>\n<p class=\"p2\"><span class=\"s1\">Three folks from our team \u2013 <b>Barb Steffens<\/b>, <b>Jan Chalupny<\/b>, and <b>Claudia Ludwig<\/b> \u2013 attended and presented at the annual Washington Science Teachers Association (WSTA) on October 12. This year brought us to Ridgeline High School in the Spokane Valley to work with educators across the state. The team presented and supported these three workshops that introduced teachers to new, hands-on, authentic science experiences designed for high school students:<\/span><\/p>\n<ul class=\"ul1\">\n<li class=\"li2\"><span class=\"s1\">Microplastics in the Arctic: Mega Problem?<\/span><\/li>\n<li class=\"li2\"><span class=\"s1\">A Hands-On Lab to Engage Students in Breast Cancer Research (presented in partnership with our collaborator <a href=\"https:\/\/embitec.com\/\"><span class=\"s2\">EmbiTec<\/span><\/a>)\u00a0<\/span><\/li>\n<li class=\"li2\"><span class=\"s1\">Fungus Among Us \u2013 Valley Fever Investigation\u00a0 (led by EmbiTec)<\/span><\/li>\n<\/ul>\n<p class=\"p2\"><span class=\"s1\">We also connected with other leaders in education including Fred Hutch\u2019s Science Education Partnership and the state\u2019s Office of Superintendent for Public Instruction.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the November installment of the 2024-25 academic year roundup, we highlight some of the top projects the ISB Education team is working on. This month, ISB hosted Ignite STEM, an annual fundraiser that raised more than $50,000 for the ISB Education team&#8217;s important work, and more.<\/p>\n","protected":false},"author":49,"featured_media":135461,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[29],"tags":[537,52,24,434],"class_list":["post-136632","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-education","tag-baliga-lab","tag-dr-nitin-baliga","tag-isb-education","tag-systems-education-experiences"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.8 (Yoast SEO v21.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>2024-25 School Year ISB Education Highlights &#183; Institute for Systems Biology<\/title>\n<meta name=\"description\" content=\"Each month throughout the 2024-25 academic year, we will highlight some of the top projects the ISB Education team is working on.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/isbscience.org\/news\/2024\/11\/26\/2024-25-school-year-isb-education-highlights\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"2024-25 School Year ISB Education Highlights\" \/>\n<meta property=\"og:description\" content=\"Each month throughout the 2024-25 academic year, we will highlight some of the top projects the ISB Education team is working on.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/isbscience.org\/news\/2024\/11\/26\/2024-25-school-year-isb-education-highlights\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Systems Biology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/isbsci\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-26T17:28:47+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-27T14:29:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/isbscience.org\/wp-content\/uploads\/spotlight-ISB-Education.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Joe Myxter\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@isbsci\" \/>\n<meta name=\"twitter:site\" content=\"@isbsci\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Joe Myxter\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/isbscience.org\/news\/2024\/11\/26\/2024-25-school-year-isb-education-highlights\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/isbscience.org\/news\/2024\/11\/26\/2024-25-school-year-isb-education-highlights\/\"},\"author\":{\"name\":\"Joe Myxter\",\"@id\":\"https:\/\/isbscience.org\/#\/schema\/person\/c2a147fbd9132363d18318b6bdabcc8d\"},\"headline\":\"2024-25 School Year ISB Education Highlights\",\"datePublished\":\"2024-11-26T17:28:47+00:00\",\"dateModified\":\"2024-11-27T14:29:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/isbscience.org\/news\/2024\/11\/26\/2024-25-school-year-isb-education-highlights\/\"},\"wordCount\":901,\"publisher\":{\"@id\":\"https:\/\/isbscience.org\/#organization\"},\"keywords\":[\"Baliga Lab\",\"Dr. Nitin Baliga\",\"ISB education\",\"Systems Education Experiences\"],\"articleSection\":[\"Education\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/isbscience.org\/news\/2024\/11\/26\/2024-25-school-year-isb-education-highlights\/\",\"url\":\"https:\/\/isbscience.org\/news\/2024\/11\/26\/2024-25-school-year-isb-education-highlights\/\",\"name\":\"2024-25 School Year ISB Education Highlights &#183; 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Jennifer Hadlock and Alexandra Ralevski\" width=\"1600\" height=\"914\" srcset=\"https:\/\/isbscience.org\/wp-content\/uploads\/\/hadlock-ralevksi.jpg 1600w, https:\/\/isbscience.org\/wp-content\/uploads\/\/hadlock-ralevksi-300x171.jpg 300w, https:\/\/isbscience.org\/wp-content\/uploads\/\/hadlock-ralevksi-1024x585.jpg 1024w, https:\/\/isbscience.org\/wp-content\/uploads\/\/hadlock-ralevksi-768x439.jpg 768w, https:\/\/isbscience.org\/wp-content\/uploads\/\/hadlock-ralevksi-1536x877.jpg 1536w, https:\/\/isbscience.org\/wp-content\/uploads\/\/hadlock-ralevksi-960x548.jpg 960w, https:\/\/isbscience.org\/wp-content\/uploads\/\/hadlock-ralevksi-600x343.jpg 600w\" sizes=\"(max-width: 1600px) 100vw, 1600px\" \/><p id=\"caption-attachment-136654\" class=\"wp-caption-text\">ISB Associate Professor Dr. Jennifer Hadlock, left, and Dr. Alexandra Ralevski.<\/p><\/div>\n<p class=\"p1\"><span class=\"s1\">Institute for Systems Biology (ISB) researchers have gained new insights into the strengths and limitations of using artificial intelligence (AI) to identify social determinants of health from electronic health records. Their peer-reviewed results <a href=\"https:\/\/www.jmir.org\/2024\/1\/e63445\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">were published on November 19<\/span><\/a>.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The ISB team, collaborating with Providence, leveraged large language models (LLM) developed from generative pre-trained transformers (GPT). Their research was conducted completely within the secure Providence internal environment.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The study \u2013 aimed at detecting housing instability \u2013 was conducted on over 25,000 clinical notes from 795 pregnant women and evaluated two large language models (GPT-4 and GPT-3.5), a named entity recognition model, regular expressions, and human review.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">This research goes beyond previous studies in two important ways. First, researchers measured how well AI can find housing challenges, distinguish between current and past housing instability, and provide direct evidence from clinical notes. Second, they measured whether AI performed differently if the notes had been de-identified.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">GPT-4 was the most effective of the four technologies tested, and was better than humans at finding cases of housing instability (recall). Humans, however, were better at understanding when people did not have housing instability (precision). Humans were also better at providing correct evidence from a clinical note.<\/span><\/p>\n<blockquote>\n<p class=\"p1\"><span class=\"s1\">\u201cThese results show that LLMs present a scalable, cost-effective solution for an initial search for patients who may benefit from outreach,\u201d said <a href=\"https:\/\/isbscience.org\/bio\/jennifer-hadlock-md\/\">ISB Associate Professor Jennifer Hadlock, MD<\/a>, corresponding author of the paper.<\/span><\/p>\n<\/blockquote>\n<p class=\"p1\"><span class=\"s1\">GPT-4 generally provided the same text that humans had selected to justify answers. Notably, no hallucinated comments appeared in the GPT-4 responses that were reviewed, most likely because the researchers designed the LLM instructions to request verbatim evidence from notes.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">However, there were cases where the AI interpretation of note text was incorrect in ways that could be misleading. This is especially important because housing status can intersect with many other challenging or risky situations, such as domestic abuse.<\/span><\/p>\n<blockquote>\n<p class=\"p1\"><span class=\"s1\">\u201cWhen a healthcare professional decides whether and how to reach out to offer help, they take great care to consider patient safety. Our results illustrate that it would still be essential to have a human read the actual text in the chart, not just the LLM summary,\u201d Hadlock added.<\/span><\/p>\n<\/blockquote>\n<p class=\"p1\"><span class=\"s1\">Further, in a novel experiment, researchers showed that recall was worse when run on de-identified versions of the same clinical notes. These notes had been de-identified with an automated technique called \u201chide in plain sight,\u201d which replaces potentially sensitive information (such as names, locations and dates) with realistic but fictitious alternatives. The de-identification sometimes reclassified critical information enough to skew the ability to accurately determine housing instability.<\/span><\/p>\n<blockquote>\n<p class=\"p1\"><span class=\"s1\">\u201cThis highlights the need to refine de-identification methods to preserve privacy without losing important details about social determinants of health,\u201d said Alexandra Ralevski, PhD, lead author of the study.<\/span><\/p>\n<\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>New peer-reviewed research out of ISB highlights the strengths of large language models in uncovering social determinants of health while underscoring the need for human oversight and improved de-identification methods.<\/p>\n","protected":false},"author":49,"featured_media":136654,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1575,846],"tags":[1609,1608,1579,1465,1611,1612,1535,1610],"class_list":["post-136653","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pregnancy-health","category-press-release","tag-ai","tag-artificial-intelligence","tag-dr-jennifer-hadlock","tag-electronic-health-records","tag-gpt","tag-gpt-4","tag-hadlock-lab","tag-large-language-models"],"acf":[],"yoast_head":"<!-- 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Biology"},"image":{"@id":"https:\/\/isbscience.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/isbsci","https:\/\/twitter.com\/isbsci","https:\/\/www.instagram.com\/isbsci","https:\/\/www.linkedin.com\/company\/institute-for-systems-biology","https:\/\/www.youtube.com\/user\/ISBSystemsBiology"]},{"@type":"Person","@id":"https:\/\/isbscience.org\/#\/schema\/person\/c2a147fbd9132363d18318b6bdabcc8d","name":"Joe Myxter","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/isbscience.org\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/2fe84cf0d44c1793865a76029b00cbac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/2fe84cf0d44c1793865a76029b00cbac?s=96&d=mm&r=g","caption":"Joe Myxter"},"url":"https:\/\/isbscience.org\/news\/author\/joem\/"}]}},"_links":{"self":[{"href":"https:\/\/isbscience.org\/wp-json\/wp\/v2\/posts\/136653"}],"collection":[{"href":"https:\/\/isbscience.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/isbscience.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/isbscience.org\/wp-json\/wp\/v2\/users\/49"}],"replies":[{"embeddable":true,"href":"https:\/\/isbscience.org\/wp-json\/wp\/v2\/comments?post=136653"}],"version-history":[{"count":0,"href":"https:\/\/isbscience.org\/wp-json\/wp\/v2\/posts\/136653\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/isbscience.org\/wp-json\/wp\/v2\/media\/136654"}],"wp:attachment":[{"href":"https:\/\/isbscience.org\/wp-json\/wp\/v2\/media?parent=136653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/isbscience.org\/wp-json\/wp\/v2\/categories?post=136653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/isbscience.org\/wp-json\/wp\/v2\/tags?post=136653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":136645,"date":"2024-11-13T11:52:41","date_gmt":"2024-11-13T19:52:41","guid":{"rendered":"https:\/\/isbscience.org\/?p=136645"},"modified":"2024-11-15T09:45:59","modified_gmt":"2024-11-15T17:45:59","slug":"sid-venkatesh-publishes-co-first-authored-paper-in-science","status":"publish","type":"post","link":"https:\/\/isbscience.org\/news\/2024\/11\/13\/sid-venkatesh-publishes-co-first-authored-paper-in-science\/","title":{"rendered":"Sid Venkatesh Publishes Co-First Authored Paper in <i>Science<\/i>"},"content":{"rendered":"<div id=\"attachment_136649\" style=\"width: 2570px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-136649\" class=\"wp-image-136649 size-full\" src=\"https:\/\/isbscience.org\/wp-content\/uploads\/ISB-May-2024-483-scaled.jpg\" alt=\"Dr. Sid Venkatesh\" width=\"2560\" height=\"1707\" srcset=\"https:\/\/isbscience.org\/wp-content\/uploads\/\/ISB-May-2024-483-scaled.jpg 2560w, https:\/\/isbscience.org\/wp-content\/uploads\/\/ISB-May-2024-483-300x200.jpg 300w, https:\/\/isbscience.org\/wp-content\/uploads\/\/ISB-May-2024-483-1024x683.jpg 1024w, https:\/\/isbscience.org\/wp-content\/uploads\/\/ISB-May-2024-483-768x512.jpg 768w, https:\/\/isbscience.org\/wp-content\/uploads\/\/ISB-May-2024-483-1536x1024.jpg 1536w, https:\/\/isbscience.org\/wp-content\/uploads\/\/ISB-May-2024-483-2048x1365.jpg 2048w, https:\/\/isbscience.org\/wp-content\/uploads\/\/ISB-May-2024-483-1800x1200.jpg 1800w, https:\/\/isbscience.org\/wp-content\/uploads\/\/ISB-May-2024-483-960x640.jpg 960w, https:\/\/isbscience.org\/wp-content\/uploads\/\/ISB-May-2024-483-600x400.jpg 600w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><p id=\"caption-attachment-136649\" class=\"wp-caption-text\">ISB Assistant Professor Sid Venkatesh and his team. (Scott Eklund\/Red Box Pictures)<\/p><\/div>\n<p class=\"p1\"><span class=\"s1\">ISB Assistant Professor <a href=\"https:\/\/isbscience.org\/bio\/sid-venkatesh-phd\/\"><span class=\"s2\">Dr. Sid Venkatesh<\/span><\/a> is the co-first author of a <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ado6828\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">paper in the journal <i>Science<\/i>.<\/span><\/a><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Following his 2019 work, where he co-led the development of a new class of nutritional interventions, <strong><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aau4732\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">microbiota-directed complementary foods (MDCFs)<\/span><\/a><\/strong>, Venkatesh and Dr. Jiye Cheng (co-first author on the recent paper) identified a novel gut microbial enzyme that impacts satiety-related signaling pathways in undernourished children treated with MDCFs.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Venkatesh made the discovery as a postdoctoral research associate in Dr. Jeffrey I. Gordon\u2019s laboratory at Washington University in St. Louis. <a href=\"https:\/\/isbscience.org\/news\/2024\/01\/04\/sid-venkatesh-joins-isb-as-assistant-professor\/\"><span class=\"s2\">He joined ISB\u2019s faculty<\/span><\/a> in September 2023 and runs the <a href=\"https:\/\/venkatesh.isbscience.org\/\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">Venkatesh Lab<\/span><\/a>, where he and his research group develop experimental tools and approaches to explore host-microbiome and host-pathogen interactions.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">He is also an Affiliate Assistant Professor in the Department of Microbiology at the University of Washington and is an active member of UW\u2019s Microbial Interactions and Microbiome Center (mim_c) community.<\/span><\/p>\n<ul class=\"ul1\">\n<li class=\"li1\"><strong><span class=\"s1\">Read the <i>Science<\/i> paper <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ado6828\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">here<\/span><\/a>.<\/span><\/strong><\/li>\n<li class=\"li1\"><strong><span class=\"s1\">Read UW mim_c\u2019s interesting and informative news story <a href=\"https:\/\/mimcuw.org\/newsevents\/a-gut-microbial-enzyme-that-impacts-host-signaling-in-child-undernutrition\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">here<\/span><\/a>.<\/span><\/strong><\/li>\n<li class=\"li1\"><strong><span class=\"s1\">Read WashU\u2019s press release <a href=\"https:\/\/medicine.washu.edu\/news\/beneficial-gut-microbe-has-surprising-metabolic-capabilities\/\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">here<\/span><\/a>.<\/span><\/strong><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>ISB Assistant Professor Dr. Sid Venkatesh is the co-first author of a paper in the journal Science. While at Washington University in St. Louis, Venkatesh and colleagues identified a novel gut microbial enzyme that impacts satiety-related signaling pathways in undernourished children treated with microbiota-directed complementary foods.<\/p>\n","protected":false},"author":49,"featured_media":136649,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1606,846,811],"tags":[581,1590,1591],"class_list":["post-136645","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-microbiome-health","category-press-release","category-spotlight","tag-gut-microbiome","tag-sid-venkatesh","tag-venkatesh-lab"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.8 (Yoast SEO v21.8) - 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Member Faduma Hussein Joins ISB as Public Health Ambassador Coordinator"},"content":{"rendered":"<div id=\"attachment_136633\" style=\"width: 1210px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-136633\" class=\"wp-image-136633 size-full\" src=\"https:\/\/isbscience.org\/wp-content\/uploads\/Faduma-Hussein.jpg\" alt=\"\" width=\"1200\" height=\"800\" srcset=\"https:\/\/isbscience.org\/wp-content\/uploads\/\/Faduma-Hussein.jpg 1200w, https:\/\/isbscience.org\/wp-content\/uploads\/\/Faduma-Hussein-300x200.jpg 300w, https:\/\/isbscience.org\/wp-content\/uploads\/\/Faduma-Hussein-1024x683.jpg 1024w, https:\/\/isbscience.org\/wp-content\/uploads\/\/Faduma-Hussein-768x512.jpg 768w, https:\/\/isbscience.org\/wp-content\/uploads\/\/Faduma-Hussein-960x640.jpg 960w, https:\/\/isbscience.org\/wp-content\/uploads\/\/Faduma-Hussein-600x400.jpg 600w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><p id=\"caption-attachment-136633\" class=\"wp-caption-text\">Faduma Hussein is the newest AmeriCorps member to join ISB.<\/p><\/div>\n<p class=\"p1\"><span class=\"s1\">Faduma Hussein recently joined the <a href=\"https:\/\/isbscience.org\/education\/\">ISB Education team<\/a> as the Public Health Ambassador Coordinator, becoming only the fourth AmeriCorps member to serve at ISB. In this Q&amp;A, she shares insights into her education, what drew her to ISB, career aspirations, and more.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Please read on and get to know Faduma Hussein.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>ISB: How long have you been in the AmeriCorps?<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Faduma Hussein: <\/b>I did a summer service term before I started my degree, but this is my first full year as a member.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>ISB: What attracted you to ISB?<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>FH: <\/b>After reading the posting for this position, I became interested in systems biology and the research being conducted here. I hadn\u2019t heard much about ISB so I explored the website and read more about the <a href=\"https:\/\/see.isbscience.org\/\" target=\"_blank\" rel=\"noopener\">Systems Education Experiences program<\/a>.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>ISB: What projects are you working on (or will you be working on)?<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>FH: <\/b>Currently, I\u2019m guiding students to improve their leadership skills for the Fall 2024 cohort <a href=\"https:\/\/see.isbscience.org\/resources\/for-students\/leads\/\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">LEADS program<\/span><\/a> for ambassadors. In addition, I\u2019m learning more about the available programs and content. I\u2019m reading through the lessons in the four-module, 180-hour <a href=\"https:\/\/see.isbscience.org\/modules\/systems-medicine\/\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">Systems Medicine course<\/span><\/a> taught in Washington state high schools.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">I am also viewing <a href=\"https:\/\/see.isbscience.org\/projects\/featured\/\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">previous student projects<\/span><\/a>, which has led me to brainstorm ideas for a new project that connects my interests with students&#8217; interests. I\u2019m passionate about biology, public health education, and health equity so I would like to center my project around those topics. I want to create a micro-course that would inspire students to improve the health of their community from a systems-thinking viewpoint.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>ISB: What do you hope to accomplish in your time here?<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>FH: <\/b>I plan to help high school students develop their systems thinking skills and how they can utilize those skills to improve the overall health of their communities. I aspire to show students the impactful work being accomplished at ISB and how they can start the journey to becoming STEM leaders.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>ISB: What is your education trajectory?\u00a0<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>FH:<\/b> I graduated with my bachelor&#8217;s degree and wanted to build my experience before taking my next steps. I wish to continue my education so I\u2019m looking into graduate programs that are relevant to my path.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>ISB: What are your career aspirations?\u00a0<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>FH: <\/b>I\u2019ve always been interested in health and human biology. I want to work with health information on the collection and analytic side to improve health outcomes.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>ISB: What do you do when you\u2019re not working?<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>FH: <\/b>I like to read, swim, and spend time with my family. My family is spread out location-wise (Asia, Europe, North America) so I try to visit them whenever possible.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>ISB: What is the last book you read?\u00a0<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>FH:<\/b> I like to read anything that I want to learn more about. It can be fiction or nonfiction. Most of the time, I\u2019m drawn to topics such as health, technology, mysteries, and thrillers. While I read for fun, I try to look for books that stimulate my brain and leave an impact.\u00a0\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>ISB: What special skill would people be surprised to learn about you?<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>FH:<\/b> Something surprising about me is that I\u2019m an above-average swimmer. I first took up swimming as a child and later regained interest. I think I averaged more than 1,500 meters before hitting the half-hour mark. I was surprised how quickly everything came back to me. I still remembered all of the techniques despite the gap.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Faduma Hussein recently joined the ISB Education team as the Public Health Ambassador Coordinator, becoming only the fourth AmeriCorps member to serve at ISB. In this Q&#038;A, she shares insights into her education, what drew her to ISB, career aspirations, and more.<\/p>\n","protected":false},"author":49,"featured_media":136633,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[29,811],"tags":[24,224,434],"class_list":["post-136648","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-education","category-spotlight","tag-isb-education","tag-logan-center-for-education","tag-systems-education-experiences"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.8 (Yoast SEO v21.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>AmeriCorps Member Faduma Hussein Joins ISB as Public Health Ambassador Coordinator &#183; Institute for Systems Biology<\/title>\n<meta name=\"description\" content=\"This Q&amp;A spotlights AmeriCorps member Faduma Hussein, who recently joined the ISB Education team as the Public Health Ambassador Coordinator.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/isbscience.org\/news\/2024\/11\/13\/americorps-member-faduma-hussein-joins-isb-as-public-health-ambassador-coordinator\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AmeriCorps Member Faduma Hussein Joins ISB as Public Health Ambassador Coordinator\" \/>\n<meta property=\"og:description\" content=\"This Q&amp;A spotlights AmeriCorps member Faduma Hussein, who recently joined the ISB Education team as the Public Health Ambassador Coordinator.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/isbscience.org\/news\/2024\/11\/13\/americorps-member-faduma-hussein-joins-isb-as-public-health-ambassador-coordinator\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Systems Biology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/isbsci\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-13T17:49:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/isbscience.org\/wp-content\/uploads\/Faduma-Hussein.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Joe Myxter\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@isbsci\" \/>\n<meta name=\"twitter:site\" content=\"@isbsci\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Joe Myxter\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/isbscience.org\/news\/2024\/11\/13\/americorps-member-faduma-hussein-joins-isb-as-public-health-ambassador-coordinator\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/isbscience.org\/news\/2024\/11\/13\/americorps-member-faduma-hussein-joins-isb-as-public-health-ambassador-coordinator\/\"},\"author\":{\"name\":\"Joe Myxter\",\"@id\":\"https:\/\/isbscience.org\/#\/schema\/person\/c2a147fbd9132363d18318b6bdabcc8d\"},\"headline\":\"AmeriCorps Member Faduma Hussein Joins ISB as Public Health Ambassador Coordinator\",\"datePublished\":\"2024-11-13T17:49:06+00:00\",\"dateModified\":\"2024-11-13T17:49:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/isbscience.org\/news\/2024\/11\/13\/americorps-member-faduma-hussein-joins-isb-as-public-health-ambassador-coordinator\/\"},\"wordCount\":601,\"publisher\":{\"@id\":\"https:\/\/isbscience.org\/#organization\"},\"keywords\":[\"ISB education\",\"Logan Center for Education\",\"Systems Education Experiences\"],\"articleSection\":[\"Education\",\"Spotlight\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/isbscience.org\/news\/2024\/11\/13\/americorps-member-faduma-hussein-joins-isb-as-public-health-ambassador-coordinator\/\",\"url\":\"https:\/\/isbscience.org\/news\/2024\/11\/13\/americorps-member-faduma-hussein-joins-isb-as-public-health-ambassador-coordinator\/\",\"name\":\"AmeriCorps Member Faduma Hussein Joins ISB as Public Health Ambassador Coordinator &#183; 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Recent work has shown that many of these microbial genes are essential to the proper functioning of our bodies, with almost half of all metabolites in human blood significantly associated with variation in the ecology of the gut.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">This metabolic cross-talk between our microbes and our bodies extends to all organ systems, including the central nervous system. There has been an explosion of research into the two-way communication between the gut microbiota and the brain, which has helped us to understand complex behavioral and neurophysiological phenotypes in many animal species.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">This year, <a href=\"https:\/\/isbscience.org\/microbiome2024\/\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">ISB hosted a three-day microbiome-themed course<\/span><\/a> (days 1 and 2) and symposium (day 3) dedicated to exploring the gut-brain axis.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">You can view videos from each day below.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Day 1<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"2024 Microbiome Course \u2013 Day 1\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/bR7AFbLiNGo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Day 1 of the 2024 ISB Virtual Microbiome Series included a two-part presentation from Alyssa Easton on analyzing amplicon sequencing data with Qiime 2, and a talk by Jacob Cavon on using wearables data to examine the relationship between the gut microbiome and sleep.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Day 2<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"2024 Microbiome Course \u2013 Day 2\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/ZyzCbSVI9JE?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Day 2 of the 2024 ISB Virtual Microbiome Series included presentations from Alex Carr on microbial community-scale metabolic models and metabolic models and the gut-brain axis.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Day 3<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"2024 Microbiome Symposium\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/vDiIJMY0hUE?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Day 3 of the 2024 ISB Virtual Microbiome Series was a symposium consisting of scientific presentations and Q&amp;A conversations.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The first session was titled Early Life: Nutrition and the Developing Brain, and included a talk by Dr. Elena Coley-O\u2019Rourke titled \u201cMalnutrition and the developmental gut-brain axis\u201d and a talk by Dr. Sid Venkatesh titled \u201cMicrobiome-targeted dietary regimens to combat pediatric undernutrition.\u201d Following the talks, Crystal Perez chaired a panel discussion.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The second session was titled Stress, Anxiety, and Depression. It included a talk by Dr. Nathaniel Ritz titled \u201cStress gone viral: gut bugs that can impact behavior in preclinical models\u201d and by Dr. Hannah Holscher titled \u201cDietary and microbial connections to mood and cognition.\u201d Following the talks, Jacob Cavon chaired a panel discussion.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The third session was titled Neurodegeneration and included a talk by Dr. Priyanka Baloni titled \u201cIdentifying host and microbiome-derived metabolic signatures associated with Alzheimer\u2019s disease, and a talk by Dr. Yunguang Qiu titled \u201cSystematic multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer\u2019s disease. Following the talks, Dr. Noa Rappaport chaired a panel discussion.<\/span><\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=bR7AFbLiNGo&amp;list=PLOojCp_ZOt2deUjJb4HmsPmRhGhtAqIrW\" target=\"_blank\" rel=\"noopener\"><strong>Watch the video playlist on YouTube here<\/strong><\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>There has been an explosion of research into the two-way communication between the gut microbiota and the brain, which has helped us to understand complex behavioral and neurophysiological phenotypes in many animal species. This year, ISB hosted a virtual microbiome series dedicated to exploring the gut-brain axis. <\/p>\n","protected":false},"author":49,"featured_media":136593,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1607,1606,77],"tags":[1248,1249,1603,581,1622,145,1451],"class_list":["post-136675","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gibbons-lab","category-microbiome-health","category-video-isb-news","tag-dr-sean-gibbons","tag-gibbons-lab","tag-gut-health","tag-gut-microbiome","tag-gut-brain-axis","tag-microbiome","tag-microbiome-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.8 (Yoast SEO v21.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A Gut Feeling: Microbes and Their Impacts on Our Minds &#183; Institute for Systems Biology<\/title>\n<meta name=\"description\" content=\"This year, ISB hosted a two-day virtual microbiome course and one-day symposium dedicated to exploring the gut-brain axis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/isbscience.org\/news\/2024\/10\/28\/a-gut-feeling-microbes-and-their-impacts-on-our-minds\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Gut Feeling: Microbes and Their Impacts on Our Minds\" \/>\n<meta property=\"og:description\" content=\"This year, ISB hosted a two-day virtual microbiome course and one-day symposium dedicated to exploring the gut-brain axis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/isbscience.org\/news\/2024\/10\/28\/a-gut-feeling-microbes-and-their-impacts-on-our-minds\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Systems Biology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/isbsci\" \/>\n<meta property=\"article:published_time\" content=\"2024-10-28T14:02:28+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-06T15:12:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/isbscience.org\/wp-content\/uploads\/2024-Microbiome_Course-OG.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"650\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Joe Myxter\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@isbsci\" 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Celebrating Professor Ilya Shmulevich\u2019s Life and Scientific Contributions"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">ISB hosted a full-day symposium \u2013 titled <a href=\"https:\/\/isbscience.org\/resonance\/\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">Resonance<\/span><\/a> \u2013 celebrating the life and scientific contributions of Professor Ilya Shmulevich, <a href=\"https:\/\/isbscience.org\/news\/2024\/06\/05\/a-life-like-no-other-remembering-beloved-isb-professor-ilya-shmulevich\/\"><span class=\"s2\">who passed away in April 2024<\/span><\/a> from complications of acute myeloid leukemia.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The symposium featured speakers whose research resonates with and has been profoundly influenced by Dr. Shmulevich\u2019s work. Session topics included digital health, modeling and theory, and cancer genomics, reflecting the broad impact of his scientific legacy.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The day-long event was recorded. You can <span class=\"s3\"><a href=\"https:\/\/www.youtube.com\/watch?v=wU9K09LrCaE&amp;list=PLOojCp_ZOt2f2s6vq2jRK3oRBrBru5d01\" target=\"_blank\" rel=\"noopener\">view the entire Resonance playlist on YouTube<\/a>, or watch the videos below<\/span><span class=\"s4\"><b>.<\/b><\/span><\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Dr. Jim Heath\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/wU9K09LrCaE?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\">\n<p class=\"p1\"><span class=\"s1\">Dr. Jim Heath delivers opening remarks.\u00a0<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Dr. Leroy Hood\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/wHd-BHAw6QM?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Dr. Lee Hood: \u201cMy Interactions with Ilya and the Human Phenome Initiative\u201d<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Dr. Sui Huang\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/lh8fuSHA01c?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Dr. Sui Huang: \u201cFrom Boolean Networks to Digital Twins\u201d<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Dr. Reinhard Laubenbacher\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/NHkYjYgc9iM?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Dr. Reinhard Laubenbacher: \u201cIlya Shmulevich and His Work on Cancer Digital Twins\u201d<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Dr. Olli Yli Harja\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/jt9QByuFOjk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Dr. Olli Yi-Harja: \u201cModeling with Ilya\u201d<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Dr. Stuart Kauffman\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/9Q-6pT9-9iM?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Dr. Stuart Kauffman<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Morning Session Discussion\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/BEK5_PKD9ms?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Morning session discussion<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Dr. Theo Knijnenburg\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/boI6VLjZT4w?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Dr. Theo Knijnenburg: Session on Cancer Genomics<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Dr. Wei Zhang\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/fPx7A7L1uUA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Dr. Wei Zhang: \u201cIlya Shmulevich\u2019s Impact: Bridging Cancer Genomics and Systems Science\u201d<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Dr. Nyasha Chambwe\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/VtGFdjYU7rQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Dr. Nyasha Chambwe: \u201cThe Enduring Influence of Ilya Shmulevich in Cancer Genomics\u201d<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Dr. Peter Laird\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/Q8m2OUJWHkg?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Dr. Peter Laird<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Resonance - Afternoon Session &amp; Closing Remarks\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/n72wNp04qLY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"p1\"><span class=\"s1\">Afternoon session and closing remarks<\/span><\/p>\n<p class=\"p3\"><span class=\"s3\"><a href=\"https:\/\/www.youtube.com\/watch?v=wU9K09LrCaE&amp;list=PLOojCp_ZOt2f2s6vq2jRK3oRBrBru5d01\"><b>View the entire Resonance playlist on YouTube<\/b><\/a><\/span><span class=\"s4\"><b>.<\/b><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ISB hosted a full-day symposium \u2013 titled Resonance \u2013 celebrating the life and scientific contributions of Professor Ilya Shmulevich, who passed away in April 2024 from complications of acute myeloid leukemia. <\/p>\n","protected":false},"author":49,"featured_media":136583,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[77],"tags":[1621,1519,106,1620],"class_list":["post-136674","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-video-isb-news","tag-cancer-genomics","tag-digital-twin","tag-dr-ilya-shmulevich","tag-resonance"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.8 (Yoast SEO v21.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ 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Microbes Evolve to Spatially Divide and Conquer an Environment\u00a0"},"content":{"rendered":"<div id=\"attachment_136590\" style=\"width: 1136px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-136590\" class=\"wp-image-136590 size-full\" src=\"https:\/\/isbscience.org\/wp-content\/uploads\/JV_FBRSchematic.gif\" alt=\"Fluidized bed reactor\" width=\"1126\" height=\"626\" \/><p id=\"caption-attachment-136590\" class=\"wp-caption-text\">This customized fluidized bed reactor uses an up-flow current to \u201cfluidize\u201d a bed of solid particles into a suspension, similar to how soil particles are suspended in flowing groundwater in the subsurface.<\/p><\/div>\n<p class=\"p1\"><span class=\"s1\">Methane is produced naturally \u2013\u00a0expelled by wetlands, wild animals, and other sources \u2013\u00a0and via manmade sources like agriculture and fossil fuel production and use. While not as abundant as carbon dioxide in our atmosphere, methane traps significantly more heat, making it a critical-to-understand component in climate change.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Researchers in the Institute for Systems Biology\u2019s Baliga Lab examined representative organisms of two classes of microbes whose interaction contributes to the conversion of more than 1 gigaton of carbon into methane every year. They <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-51759-y\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">published their work in <i>Nature Communications<\/i><\/span><\/a>.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">ISB Senior Research Scientist <a href=\"https:\/\/isbscience.org\/bio\/jacob-j-valenzuela-phd\/\"><span class=\"s2\">Dr. Jacob Valenzuela<\/span><\/a>, who led the project, found that gene mutations selected over a relatively short timeframe in the two microbes \u2013\u00a0<i>Desulfovibrio vulgaris<\/i> (Dv) and <i>Methanococcus maripaludis<\/i> (Mm) \u2013 led to distinct functions, specifically ecotypes (sub-populations) that are more specialized to either an attached or floating lifestyle.<\/span><\/p>\n<blockquote>\n<p class=\"p1\"><span class=\"s1\">\u201cWe showed that ecotypes of the same species can emerge over very short evolutionary timescales to specialize and collaborate with ecotypes of other species to significantly increase the productivity of ecologically important functions, such as methane production,\u201d Valenzuela said.<\/span><\/p>\n<\/blockquote>\n<h5 class=\"p1\"><span class=\"s1\">Lab Work<\/span><\/h5>\n<p class=\"p1\"><span class=\"s1\">The team built a customized fluidized bed reactor to simulate the soil subsurface, where methane-producing microbial communities are typically found. The reactor uses an up-flow current to \u201cfluidize\u201d a bed of solid particles into a suspension, similar to how soil particles are suspended in flowing groundwater in the subsurface. \u201cThis reactor system allowed us to examine complex microbial interactions that normally occur in the soil subsurface, but in a controlled laboratory experiment,\u201d Valenzuela said.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Using this reactor system, they discovered that just a handful of mutations that were selected within 300-1,000 generations (for reference, months in the lab) of growing Dv and Mm as a microbial community in an obligate relationship had generated new ecotypes of each organism, where each ecotype had specialized to carry out specific roles in the simulated subsurface environment.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">New ecotypes of Dv that had specialized to survive as biofilm attached to a sediment particle utilized more lactate, generating a byproduct of molecular hydrogen (H<\/span><span class=\"s3\"><sub>2<\/sub><\/span><span class=\"s1\">) that nearby ecotypes of attached Mm could only partially utilize. The unused H<\/span><span class=\"s3\"><sub>2<\/sub><\/span><span class=\"s1\"> was then scavenged by free-flowing Mm ecotypes, and used for producing a large amount of methane.\u00a0\u00a0<\/span><\/p>\n<blockquote>\n<p class=\"p1\"><span class=\"s1\">\u201cThis novel experiment shows how few mutations are needed to generate ecotypes of microorganisms specialized to new environmental niches,\u201d said <a href=\"https:\/\/isbscience.org\/bio\/nitin-baliga\/\"><span class=\"s2\">Dr. Nitin Baliga<\/span><\/a>, corresponding author of the paper. \u201cOur findings further show that the synergistic interplay among ecotypes of diverse microbes across space and time can dramatically improve the productivity of the entire microbial community. In so doing, this study provides insight into the remarkable ability of microbial communities to adapt, specialize, and collaborate to profoundly influence the biogeochemical cycling of gigatons of major elements like carbon, nitrogen, and phosphorus essential for sustaining life on Earth.\u201d<\/span><\/p>\n<\/blockquote>\n<h5 class=\"p1\"><span class=\"s1\">Next steps<\/span><\/h5>\n<p class=\"p1\"><span class=\"s1\">These findings underscore the importance of the enormous genetic diversity of microbes within a microbiome, be it from soil, oceans, or the human gut.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">While current DNA sequencing technologies have the sensitivity and resolution to uncover the genetic diversity within a microbiome, scientists do not yet have the microbiological and computational tools needed to fully interpret the functional meaning of this diversity.\u00a0<\/span><\/p>\n<blockquote>\n<p class=\"p1\"><span class=\"s1\">\u201cOur study illustrates the importance of investigating genomic diversity within microbiomes from a spatial, temporal, and functional context,\u201d Valenzuela said. \u201cInteractions among ecotypes of different species across these three axes may have important implications on how we diagnose health from disease or select the right mix of ecotypes of different species to use as pre\/probiotics to restore the health of an ecosystem.\u201d\u00a0<\/span><\/p>\n<\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>ISB researchers examined representative organisms of two classes of microbes whose interaction contributes to the conversion of more than 1 gigaton of carbon into methane every year. They found that gene mutations selected over a relatively short timeframe in the two microbes led to distinct functions.<\/p>\n","protected":false},"author":49,"featured_media":136590,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1048],"tags":[537,1494,52,675,530],"class_list":["post-136589","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-environment","tag-baliga-lab","tag-dr-jacob-valenzuela","tag-dr-nitin-baliga","tag-gene-mutations","tag-microbial-genome"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.8 (Yoast SEO v21.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How Microbes Evolve to Spatially Divide and Conquer an Environment\u00a0 &#183; 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