TY - JOUR
TI - The Expected Number of Viable Autocatalytic Sets in Chemical Reaction Systems
AU - Kauffman, Stuart
AU - Steel, Mike
T2 - Artificial Life
AB - The emergence of self-sustaining autocatalytic networks in chemical reaction systems has been studied as a possible mechanism for modeling how living systems first arose. It has been known for several decades that such networks will form within systems of polymers (under cleavage and ligation reactions) under a simple process of random catalysis, and this process has since been mathematically analyzed. In this paper, we provide an exact expression for the expected number of self-sustaining autocatalytic networks that will form in a general chemical reaction system, and the expected number of these networks that will also be uninhibited (by some molecule produced by the system). Using these equations, we are able to describe the patterns of catalysis and inhibition that maximize or minimize the expected number of such networks. We apply our results to derive a general theorem concerning the trade-off between catalysis and inhibition, and to provide some insight into the extent to which the expected number of self-sustaining autocatalytic networks coincides with the probability that at least one such system is present.
DA - 2021///
PY - 2021
DO - 10.1162/artl_a_00333
DP - PubMed
VL - 27
IS - 1
SP - 1
EP - 14
J2 - Artif Life
LA - eng
SN - 1530-9185
KW - autocatalytic network
KW - catalysis
KW - inhibition
KW - random process
ER -