Proteomics is the discipline of identifying and quantifying the proteins present in an organism.

If DNA is the blueprint for life, then proteins are the bricks. The genes in DNA are translated into proteins, strings of amino acids that fold into three-dimensional structures. The type and order of the amino acids in a protein will change its shape and determine its special function.

Proteins are the molecules that make life happen: They are the power plants that turn food into energy, the machines that make cells move, and even the computers that read DNA and make more proteins. The information to build every protein in an organism is contained in the DNA, but not every protein is produced at once or in the same amount.

Think of a cell in your liver and a cell in your retina – both cells contain identical DNA, but very different subsets of proteins are being produced in order to give each cell its special function.

At ISB, we use state-of-the-art scientific instruments and cutting edge computational techniques to detect thousands of proteins at once, giving us a systems-level view of the molecular machinery of life.

Featured Projects

  • Wilke Cohen Lyme Disease Project

    ISB researchers have put their efforts into looking at Lyme disease and the bacteria, Borrelia burgdorferi, that causes the disease, through the lens of systems biology, and utilizing approaches pioneered at ISB to gather, synthesize and interpret large and complex datasets.

  • Warhol style Plasmodium

    Identification of the proteins in Plasmodium vivax provide new targets for a malaria vaccine

    Scientists from ISB and the Center for Infectious Disease Research led an international collaboration to identify proteins in the malaria parasite Plasmodium vivax. P. vivax and P. falciparum cause the majority of malaria cases, but P. vivax is far less-studied, in part because it cannot be grown in the lab. The research aims to provide new targets for a malaria vaccine.

  • Proteomics: Identifying Organ-Specific Blood Biomarkers for Acute Liver Injury

    To assess probable injury to an organ, it is important to monitor biologic materials that originate exclusively or primarily in that organ, in this case, liver-enriched proteins.

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