The prize recognizes foundational discoveries about regulatory T cells and the FOXP3 gene that redefined immune tolerance and opened avenues to treat autoimmune disease, enable transplantation, and advance immuno-oncology. ISB celebrates Dr. Brunkow’s leadership and collaborative science.
The pioneering work of Mary Brunkow and Fred Ramsdell began with a mysterious mutant mouse known as “scurfy,” leading them to identify the FOXP3 gene and unlock how regulatory T cells prevent autoimmune disease — discoveries that now point to new treatments in cancer and autoimmunity.
The Biomedical Data Translator is now publicly available, offering a powerful open-source platform that integrates diverse biomedical datasets. Designed to accelerate discovery and patient care, Translator helps users explore complex data and uncover actionable insights with ease.
ISB hosted a full-day symposium – titled Resonance – celebrating the life and scientific contributions of Professor Ilya Shmulevich, who passed away in April 2024 from complications of acute myeloid leukemia.
Devoted husband and father. Animal lover. Accomplished pianist. Avid cyclist. Compassionate human. Exceptional scientist. The ISB community mourns the loss of Professor Ilya Shmulevich, PhD, who died on April 13, 2024. He was 54 years old.
The quest to create cultivated meat has been a true multidisciplinary puzzle. It’s biology, engineering, physics, bioinformatics, mathematics, computer science, and more. Enter systems biology. ISB and other organizations are toiling to better understand how to create lab-grown meat in a safe, effective manner that can eventually scale up to compete with traditional meat.
CRI iAtlas is a comprehensive web-based resource that allows oncologists and researchers to study and analyze interactions between tumors and the immune microenvironment. The iAtlas team released immuno-oncology modules that allow investigators to access and work with genomics data from trials of treatment with immune-checkpoint inhibitors.
ISB’s computational and bioinformatics teams played a central role in the completion of the PanCancer Atlas Initiative, the final phase of TCGA. The culmination of this work is being published in 27 papers this week across the Cell Press research journals, including “The Immune Landscape of Cancer” in Immunity.