Melanoma Starts Evading Treatment Within Hours – Here’s How to Stop It
ISB researchers have uncovered a stealth survival strategy that melanoma cells use to evade targeted therapy, offering a promising new approach to improving treatment outcomes.
Featured News
Scientists Decode Diet From Stool DNA – No Questions Asked
ISB’s Gibbons Lab developed a breakthrough method that analyzes food-derived DNA in fecal metagenomes, allowing for data-driven diet tracking without the need for burdensome questionnaires.
More News (Precision Treatments)
New Model Transforms Multiple Myeloma Risk Prediction
A team of researchers has developed a powerful new tool that could transform how doctors treat multiple myeloma, a complex and often unpredictable blood cancer.
New Research Uncovers Hidden Rules of Immune Response
Scientists at the Institute for Systems Biology (ISB) reveal how T cells “decide” their fate in fighting infections like COVID-19, paving the way for improved treatments for infections, cancer, and autoimmune diseases.
Breakthrough T Cell Discovery Has Huge Potential for Engineering Custom Immune Responses
In a breakthrough discovery that changes how we understand T cells and with implications of how we can better engineer custom immune responses to fight disease, Institute for Systems Biology researchers showed that the different disease-fighting functions of different T cells are determined by the genetically encoded T-cell receptor sequence that are unique to those cells.
How Immune Cells ‘See’ and Respond to Mutations in Cancer Cells
In a just-published paper in the journal Nature, a collaborative team of researchers from ISB, UCLA, PACT Pharma, and beyond analyzed T-cell responses in melanoma patients who were treated with different immune checkpoint inhibitors, and how those responses evolved over time.
In First-of-Its-Kind Trial, Scientists Use CRISPR to Treat Cancer
Scientists for the first time have used CRISPR to substitute a gene to treat patients with cancer. The remarkable findings were published in the journal Nature and presented at the Society for Immunotherapy of Cancer (SITC) 2022.
Improving Cancer Care for All: A Conversation with Drs. Jim Heath, Jim Allison and Lynda Chin
ISB President Dr. Jim Heath talks with Nobel laureate and Executive Director of the Immunotherapy Platform at MD Anderson Cancer Center Dr. Jim Allison and Apricity Health CEO Dr. Lynda Chin. Drs. Heath, Allison and Chin discuss disparities in cancer care and ways to bring state-of-the-art care from big cities and major academic centers to rural and underserved areas.