The prize recognizes foundational discoveries about regulatory T cells and the FOXP3 gene that redefined immune tolerance and opened avenues to treat autoimmune disease, enable transplantation, and advance immuno-oncology. ISB celebrates Dr. Brunkow’s leadership and collaborative science.
The pioneering work of Mary Brunkow and Fred Ramsdell began with a mysterious mutant mouse known as “scurfy,” leading them to identify the FOXP3 gene and unlock how regulatory T cells prevent autoimmune disease — discoveries that now point to new treatments in cancer and autoimmunity.
ISB’s Dr. Alice Kane explores the biology of aging, highlighting frailty as a key measure of healthspan, new biomarkers of aging, and insights into menopause and women’s health.
Researchers at the Institute for Systems Biology argue that combining systems biology, longitudinal multiomics data, and artificial intelligence could transform healthcare from reactive treatment to proactive prevention, enabling scientists and clinicians to detect early molecular signs of disease and intervene before symptoms appear.
Discussing Super Agers, Drs. Eric Topol and Lee Hood connected breakthroughs in genomics, AI, and lifestyle science to the pursuit of longer, healthier lives.
ISB hosted the Systems Biology of Aging Virtual Workshop in May 2024 for graduate students, postdocs, principal investigators, industry scientists, and educators. The course provided practical tools for performing multi-omic systems biology analyses to advance the study of aging.
Popular Mechanics interviewed ISB Co-founder and Professor Dr. Lee Hood for an article titled “Leroy Hood Wants To Show You How To Live for a Really, Really Long Time.” The story features Hood’s big-data approach and a focus on disease prevention – all in the quest to help us live longer.
ISB researchers have constructed a biological BMI that provides a more accurate representation of metabolic health and is more varied, informative and actionable than the long-used classical BMI. ISB Senior Research Scientist Dr. Noa Rappaport discussed biological BMI in a Research Roundtable presentation.