Nathan Price, PhD

Professor (on leave)

Send Emailnathan.price@isbscience.org

Lab Website: Visit Lab Websitehttp://hood-price.isbscience.org

isbscience.org/bio/nathan-price/
Nathan Price

Dr. Nathan Price is (on leave) Professor at ISB, co-director of the Hood-Price Lab for Systems Biomedicine, and served as Associate Director of the Institute from 2013 to 2020. He is currently Chief Scientific Officer of Thorne HealthTech (NASDAQ: THRN). Previously he was CEO of Onegevity, an AI health intelligence company that merged with Thorne prior to its IPO in 2021. In 2019, he was named as one of the 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine, and in 2021 he was appointed to the Board on Life Sciences of the National Academies of Sciences, Engineering, and Medicine.  He is also co-author with Lee Hood of “The Age of Scientific Wellness” (Belknap Imprint of Harvard Press, 2023).

Dr. Price is Affiliate Faculty at the University of Washington in Bioengineering and Computer Science & Engineering. Previously he was an Assistant Professor at the University of Illinois, Urbana-Champaign in Chemical & Biomolecular Engineering and at the Institute for Genomic Biology. He is a Camille Dreyfus Teacher-Scholar, received the 2016 Grace A. Goldsmith award for his work pioneering “scientific wellness,” was a co-founder of Arivale, and received a Healthy Longevity Catalyst Award from the National Academy of Medicine in 2020. He has co-authored more than 200 peer-reviewed scientific publications and given over 200 talks and keynotes. He also served as Chair of the NIH Study Section on Modeling and Analysis of Biological Systems. 

Dr. Price has won numerous awards for his work, including a Howard Temin Pathway to Independence Award from the National Institutes of Health, a National Science Foundation CAREER award, a young investigator award from the Roy J. Carver Charitable Trust, “Tomorrow’s PIs” from Genome Technology, a Camille Dreyfus Teacher-Scholar award, the Grace A. Goldsmith Award from the American College of Nutrition (given to one researcher each year under the age of 50, for his work pioneering “scientific wellness”), and is a National Academy of Medicine ELHM Scholar. In 2020, he was elected a fellow of the American Institute for Medical and Biological Engineering and received a Healthy Longevity Catalyst Award from the National Academy of Medicine for work on the microbiome and aging. He was also a finalist for the EY Entrepreneur of the Year for NY in 2021 and selected as one of the “Notables in Healthcare” by Crain’s New York in 2022. 

He has also served on the Board of Trustees of the Health and Environmental Sciences Institute (HESI), the Pacific Northwest Board of Advisors for the American Cancer Society, and the Board for the University of Virginia’s Coulter Translational Research Partnership. Dr. Price has also served on numerous advisory boards including Roche (Personalized Healthcare Division), Providence St. Joseph Health, Sera Prognostics, Navican, Basepaws, Trelys, the Novo Nordisk Foundation Center for Biosustainability, and many others. Dr. Price served on the NAM committee to review omics-based tests for clinical trials.

PhD, Bioengineering, University of California, San Diego, 2005

Computational biology, biological networks, systems medicine, translational bioinformatics, scientific wellness

View CV here

Papin, Jason A., Nathan D. Price, Jeremy S. Edwards, and Bernhard O. Palsson B. 2002. “The Genome-Scale Metabolic Extreme Pathway Structure in Haemophilus Influenzae Shows Significant Network Redundancy.” Journal of Theoretical Biology 215 (1). https://doi.org/10.1006/jtbi.2001.2499. Cite
Degelman, Douglas, and Nicole Deann Price. 2002. “Tattoos and Ratings of Personal Characteristics.” Psychological Reports 90 (2): 507–14. https://doi.org/10.2466/pr0.2002.90.2.507. Cite
Price, N. D., J. A. Papin, and B. O. Palsson. 2002. “Determination of Redundancy and Systems Properties of the Metabolic Network of Helicobacter Pylori Using Genome-Scale Extreme Pathway Analysis.” Genome Research 12 (5): 760–69. Cite
Price, Nathan D., Iman Famili, Daniel A. Beard, and Bernhard O. Palsson. 2002. “Extreme Pathways and Kirchhoff’s Second Law.” Biophysical Journal 83 (5): 2879–82. https://doi.org/10.1016/S0006-3495(02)75297-1. Cite
Papin, Jason A., Nathan D. Price, and Bernhard O. Palsson. 2002. “Extreme Pathway Lengths and Reaction Participation in Genome-Scale Metabolic Networks.” Genome Research 12 (12): 1889–1900. https://doi.org/10.1101/gr.327702. Cite
Price, Nathan D., Jennifer L. Reed, Jason A. Papin, Iman Famili, and Bernhard O. Palsson. 2003. “Analysis of Metabolic Capabilities Using Singular Value Decomposition of Extreme  Pathway Matrices.” Biophysical Journal 84 (2 Pt 1). https://doi.org/10.1016/S0006-3495(03)74899-1. Cite
Price, Nathan D., Jason A. Papin, Christophe H. Schilling, and Bernhard O. Palsson. 2003. “Genome-Scale Microbial in Silico Models: The Constraints-Based Approach.” Trends in Biotechnology 21 (4): 162–69. https://doi.org/10.1016/S0167-7799(03)00030-1. Cite
Palsson, B. O., N. D. Price, and J. A. Papin. 2003. “Development of Network-Based Pathway Definitions: The Need to Analyze Real Metabolic Networks.” Trends in Biotechnology 21 (5): 195–98. Cite
Papin, Jason A., Nathan D. Price, Sharon J. Wiback, David A. Fell, and Bernhard O. Palsson. 2003. “Metabolic Pathways in the Post-Genome Era.” Trends in Biochemical Sciences 28 (5): 250–58. https://doi.org/10.1016/S0968-0004(03)00064-1. Cite
Price, Nathan D., Jennifer L. Reed, Jason A. Papin, Sharon J. Wiback, and Bernhard O. Palsson. 2003. “Network-Based Analysis of Metabolic Regulation in the Human Red Blood Cell.” Journal of Theoretical Biology 225 (2): 185–94. Cite
Raghunathan, Anu, Nathan D. Price, Michael Y. Galperin, Kira S. Makarova, Samuel Purvine, Alex F. Picone, Tim Cherny, et al. 2004. “In Silico Metabolic Model and Protein Expression of Haemophilus Influenzae Strain Rd KW20 in Rich Medium.” Omics : A Journal of Integrative Biology 8 (1). https://doi.org/10.1089/153623104773547471. Cite
Price, Nathan D., Jennifer L. Reed, and Bernhard O. Palsson. 2004. “Genome-Scale Models of Microbial Cells: Evaluating the Consequences of Constraints.” Nature Reviews. Microbiology 2 (11): 886–97. https://doi.org/10.1038/nrmicro1023. Cite
Price, Nathan D., Jan Schellenberger, and Bernhard O. Palsson. 2004. “Uniform Sampling of Steady-State Flux Spaces: Means to Design Experiments and to  Interpret Enzymopathies.” Biophysical Journal 87 (4): 2172–86. https://doi.org/10.1529/biophysj.104.043000. Cite
Papin, Jason A., Joerg Stelling, Nathan D. Price, Steffen Klamt, Stefan Schuster, and Bernhard O. Palsson. 2004. “Comparison of Network-Based Pathway Analysis Methods.” Trends in Biotechnology 22 (8): 400–405. https://doi.org/10.1016/j.tibtech.2004.06.010. Cite
Thiele, Ines, Nathan D. Price, Thuy D. Vo, and Bernhard O. Palsson. 2005. “Candidate Metabolic Network States in Human Mitochondria. Impact of Diabetes, Ischemia, and Diet.” The Journal of Biological Chemistry 280 (12): 11683–95. https://doi.org/10.1074/jbc.M409072200. Cite
Thiele, Ines, Thuy D. Vo, Nathan D. Price, and Bernhard O. Palsson. 2005. “Expanded Metabolic Reconstruction of Helicobacter Pylori (IIT341 GSM/GPR): An in  Silico Genome-Scale Characterization of Single- and Double-Deletion Mutants.” Journal of Bacteriology 187 (16): 5818–30. https://doi.org/10.1128/JB.187.16.5818-5830.2005. Cite
Barrett, Christian L., Nathan D. Price, and Bernhard O. Palsson. 2006. “Network-Level Analysis of Metabolic Regulation in the Human Red Blood Cell Using  Random Sampling and Singular Value Decomposition.” BMC Bioinformatics 7. https://doi.org/10.1186/1471-2105-7-132. Cite
Becker, Scott A., Nathan D. Price, and Bernhard O. Palsson. 2006. “Metabolite Coupling in Genome-Scale Metabolic Networks.” BMC Bioinformatics 7. https://doi.org/10.1186/1471-2105-7-111. Cite
Allen, Timothy E., Nathan D. Price, Andrew R. Joyce, and Bernhard O. Palsson. 2006. “Long-Range Periodic Patterns in Microbial Genomes Indicate Significant Multi-Scale Chromosomal Organization.” PLoS Computational Biology 2 (1). https://doi.org/10.1371/journal.pcbi.0020002. Cite
Price, Nathan D., Ines Thiele, and Bernhard O. Palsson. 2006. “Candidate States of Helicobacter Pylori’s Genome-Scale Metabolic Network upon Application of ‘Loop Law’ Thermodynamic Constraints.” Biophysical Journal 90 (11): 3919–28. https://doi.org/10.1529/biophysj.105.072645. Cite
Gianchandani, Erwin P., Jason A. Papin, Nathan D. Price, Andrew R. Joyce, and Bernhard O. Palsson. 2006. “Matrix Formalism to Describe Functional States of Transcriptional Regulatory Systems.” PLoS Computational Biology 2 (8). https://doi.org/10.1371/journal.pcbi.0020101. Cite
Price, Nathan D., Jonathan Trent, Adel K. El-Naggar, David Cogdell, Ellen Taylor, Kelly K. Hunt, Raphael E. Pollock, Leroy Hood, Ilya Shmulevich, and Wei Zhang. 2007. “Highly Accurate Two-Gene Classifier for Differentiating Gastrointestinal Stromal  Tumors and Leiomyosarcomas.” Proceedings of the National Academy of Sciences of the United States of America 104 (9): 3414–19. https://doi.org/10.1073/pnas.0611373104. Cite
Price, Nathan D., and Ilya Shmulevich. 2007. “Biochemical and Statistical Network Models for Systems Biology.” Current Opinion in Biotechnology 18 (4): 365–70. https://doi.org/10.1016/j.copbio.2007.07.009. Cite
Price, Nathan D., Greg Foltz, Anup Madan, Leroy Hood, and Qiang Tian. 2008. “Systems Biology and Cancer Stem Cells.” Journal of Cellular and Molecular Medicine 12 (1). https://doi.org/10.1111/j.1582-4934.2007.00151.x. Cite
Nykter, Matti, Nathan D. Price, Antti Larjo, Tommi Aho, Stuart A. Kauffman, Olli Yli-Harja, and Ilya Shmulevich. 2008. “Critical Networks Exhibit Maximal Information Diversity in Structure-Dynamics Relationships.” Physical Review Letters 100 (5). Cite
Nykter, Matti, Nathan D. Price, Maximino Aldana, Stephen A. Ramsey, Stuart A. Kauffman, Leroy E. Hood, Olli Yli-Harja, and Ilya Shmulevich. 2008. “Gene Expression Dynamics in the Macrophage Exhibit Criticality.” Proceedings of the National Academy of Sciences of the United States of America 105 (6): 1897–1900. https://doi.org/10.1073/pnas.0711525105. Cite
Price, N. D., L. B. Edelman, I. Lee, H. Yoo, D. Hwang, G. Carlson, D. J. Galas, J. R. Heath, and L. Hood. 2009. “Systems Biology and the Emergence of Systems Medicine.” In Genomic and Personalized Medicine: From Principles to Practice. Elsevier. Cite
Edelman, Lucas B., Giuseppe Toia, Donald Geman, Wei Zhang, and Nathan D. Price. 2009. “Two-Transcript Gene Expression Classifiers in the Diagnosis and Prognosis of Human Diseases.” BMC Genomics 10. https://doi.org/10.1186/1471-2164-10-583. Cite
Hwang, Daehee, Inyoul Y. Lee, Hyuntae Yoo, Nils Gehlenborg, Ji-Hoon Cho, Brianne Petritis, David Baxter, et al. 2009. “A Systems Approach to Prion Disease.” Molecular Systems Biology 5. https://doi.org/10.1038/msb.2009.10. Cite
Eddy, James A., Donald Geman, and Nathan D. Price. 2009. “Relative Expression Analysis for Identifying Perturbed Pathways.” Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2009: 5456–59. https://doi.org/10.1109/IEMBS.2009.5334063. Cite
Milne, Caroline B., Pan-Jun Kim, James A. Eddy, and Nathan D. Price. 2009. “Accomplishments in Genome-Scale in Silico Modeling for Industrial and Medical Biotechnology.” Biotechnology Journal 4 (12): 1653–70. https://doi.org/10.1002/biot.200900234. Cite
Edelman, Lucas B., Sriram Chandrasekaran, and Nathan D. Price. 2010. “Systems Biology of Embryogenesis.” Reproduction, Fertility, and Development 22 (1). https://doi.org/10.1071/RD09215. Cite
Ezeji, Thaddeus, Caroline Milne, Nathan D. Price, and Hans P. Blaschek. 2010. “Achievements and Perspectives to Overcome the Poor Solvent Resistance in Acetone  and Butanol-Producing Microorganisms.” Applied Microbiology and Biotechnology 85 (6): 1697–1712. https://doi.org/10.1007/s00253-009-2390-0. Cite
Galas, D. J., M. Nykter, G. W. Carter, N. D. Price, and I. Shmulevich. 2010. “Biological Information as Set-Based Complexity.” IEEE Transactions on Information Theory 56 (2): 667–77. Cite
Eddy, James A., Jaeyun Sung, Donald Geman, and Nathan D. Price. 2010. “Relative Expression Analysis for Molecular Cancer Diagnosis and Prognosis.” Technology in Cancer Research & Treatment 9 (2): 149–59. Cite
Kim, Pan-Jun, and Nathan D. Price. 2010. “Macroscopic Kinetic Effect of Cell-to-Cell Variation in Biochemical Reactions.” Physical Review Letters 104 (14): 148103. Cite
Eddy, James A., Leroy Hood, Nathan D. Price, and Donald Geman. 2010. “Identifying Tightly Regulated and Variably Expressed Networks by Differential Rank Conservation (DIRAC).” PLoS Computational Biology 6 (5). https://doi.org/10.1371/journal.pcbi.1000792. Cite
Price, Nathan D., and Sang Yup Lee. 2010. “Editorial: Systems Biology for Biotech Applications.” Biotechnology Journal 5 (7): 636–37. https://doi.org/10.1002/biot.201000216. Cite
Edelman, Lucas B., James A. Eddy, and Nathan D. Price. 2010. “In Silico Models of Cancer.” Wiley Interdisciplinary Reviews. Systems Biology and Medicine 2 (4): 438–59. https://doi.org/10.1002/wsbm.75. Cite
Shi, Leming, Gregory Campbell, Wendell D. Jones, Fabien Campagne, Zhining Wen, Stephen J. Walker, Zhenqiang Su, et al. 2010. “The MicroArray Quality Control (MAQC)-II Study of Common Practices for the Development and Validation of Microarray-Based Predictive Models.” Nature Biotechnology 28 (8): 827–38. https://doi.org/10.1038/nbt.1665. Cite
Chandrasekaran, Sriram, and Nathan D. Price. 2010. “Probabilistic Integrative Modeling of Genome-Scale Metabolic and Regulatory Networks in Escherichia Coli and Mycobacterium Tuberculosis.” Proceedings of the National Academy of Sciences of the United States of America 107 (41): 17845–50. https://doi.org/10.1073/pnas.1005139107. Cite
Yang, Jilong, James A. Eddy, Yuan Pan, Andrea Hategan, Ioan Tabus, Yingmei Wang, David Cogdell, et al. 2010. “Integrated Proteomics and Genomics Analysis Reveals a Novel Mesenchymal to Epithelial Reverting Transition in Leiomyosarcoma through Regulation of Slug.” Molecular & Cellular Proteomics : MCP 9 (11): 2405–13. https://doi.org/10.1074/mcp.M110.000240. Cite
Ma, Shuyi, Cory C. Funk, and Nathan D. Price. 2010. “Systems Approaches to Molecular Cancer Diagnostics.” Discovery Medicine 10 (55): 531–42. Cite
Bebek, G., M. Koyuturk, M. R. Chance, and N. D. Price. 2011. “INTEGRATIVE -OMICS FOR TRANSLATIONAL SCIENCE - Session Introduction.” Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 1–3. Cite
Ghosh, Amit, Huimin Zhao, and Nathan D. Price. 2011. “Genome-Scale Consequences of Cofactor Balancing in Engineered Pentose Utilization Pathways in Saccharomyces Cerevisiae.” PloS One 6 (11). https://doi.org/10.1371/journal.pone.0027316. Cite
Milne, Caroline B., James A. Eddy, Ravali Raju, Soroush Ardekani, Pan-Jun Kim, Ryan S. Senger, Yong-Su Jin, Hans P. Blaschek, and Nathan D. Price. 2011. “Metabolic Network Reconstruction and Genome-Scale Model of Butanol-Producing Strain Clostridium Beijerinckii NCIMB 8052.” BMC Systems Biology 5. https://doi.org/10.1186/1752-0509-5-130. Cite
Cho, J. H., R. Gelinas, K. Wang, A. Etheridge, M. G. Piper, K. Batte, D. Dakhallah, et al. 2011. “Systems Biology of Interstitial Lung Diseases: Integration of MRNA and MicroRNA Expression Changes.” BMC Med Genomics 4 (1): 8. Cite
Yan, Xiaowei, Li Ma, Danielle Yi, Jae-geun Yoon, Alan Diercks, Gregory Foltz, Nathan D. Price, Leroy E. Hood, and Qiang Tian. 2011. “A CD133-Related Gene Expression Signature Identifies an Aggressive Glioblastoma Subtype with Excessive Mutations.” Proceedings of the National Academy of Sciences of the United States of America 108 (4): 1591–96. https://doi.org/10.1073/pnas.1018696108. Cite
Magis, Andrew T., John C. Earls, Youn-Hee Ko, James A. Eddy, and Nathan D. Price. 2011. “Graphics Processing Unit Implementations of Relative Expression Analysis Algorithms Enable Dramatic Computational Speedup.” Bioinformatics (Oxford, England) 27 (6): 872–73. https://doi.org/10.1093/bioinformatics/btr033. Cite
Li, Qingbo, Christopher R. Singh, Shuyi Ma, Nathan D. Price, and Chinnaswamy Jagannath. 2011. “Label-Free Proteomics and Systems Biology Analysis of Mycobacterial Phagosomes in Dendritic Cells and Macrophages.” Journal of Proteome Research 10 (5): 2425–39. https://doi.org/10.1021/pr101245u. Cite

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